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DM-Epinephrine

QuestionAnswer
Classification Sympathomimetic, Alpha-/Beta- Agonist
Action Stimulates alpha- and beta-adrenergic receptors within the sympathetic nervous system
Action - Effects Alpha-adrenergic effects include peripheral vasoconstriction at higher doses Beta-adrenergic effects include: – Increased HR – Increased force of cardiac contractility – Increased AV conduction – Bronchodilation Inhibits histamine release
Indications Anaphylaxis
Contraindications No absolute contraindications.
Cautions Cardiovascular System
Side Effects Common reactions to systemically administered epinephrine include anxiety, tremor, dizziness, sweating, palpitations, headache, and nausea
Dosage IM: 0.5 mg; may repeat every 5 minutes up to 3 times IM auto injector: typical dosage 0.15 to 0.5mg of 1:1000 epinephrine
Pediatric Considerations and Dosing Follow weight-based dosing IM: 0.01 mg/kg to a maximum of 0.5 mg; may repeat every 5 minutes up to 3 times IM auto injector, typical dose 0.3mg of 1:1000 epinephrine
Onset, Peak, Duration IM Onset: 30-90 seconds IM Peak: 4-10 minutes IM Duration: 5-10 minutes
Elimination Rapidly metabolized by enzymes in the blood, liver, and other tissues Excreted in urine
Iatrogenic Overdose Epinephrine overdose may produce significantly elevated blood pressures and heart rate, which may in turn cause cerebral hemorrhage and lethal cardiac arrhythmias.
Created by: Levelstorm3950
 

 



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