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Naplex

PAH-clinical pearl

QuestionAnswer
Epoprostenol administration Epoprostenol must be protected from light before reconstitution and during the infusion.
Drugs can cause pulmonary fibrosis - Dronedarone (Multaq) - Amiodarone - Bleomycin
Flolan vs Veletri - Epoprostenol - Flolan: continuous IV infusion (hospital or home). After reconstitution, Flolan solutions need to be kept cool with ice packs or other cooling packs. - Veletri: more stability, room temperature
Meds causes PAH - SSRI during pregnancy (Fenfluramine -brand Fintepla) - Stimulants (methamphetamines, amphetamine) - Weight loss: phentamine
TRUE or FALSE: NSAIDs should be avoid in PAH TRUE, NSAIDs increase sodium and water retention
Routine vaccine for PAH - Influenza - Pneumonia
side effects of epoprostenol Vasodilation reactions (hypotension, flushing, headache, nausea, vomiting) and jaw pain
PAH meds which is CI if Pt on nitrates PD5, Biociguat
ERA (Endothelin receptor antagonists) (MBA) - Macitentan - Bosentan - Ambrisentan MoA: stimulates endothelin receptors
Prostacyclins (T I E) - Treprostinil - lloprost - Epoprostenol
warnings associated with tadalafil (Adcirca) PDE-5 have a warning for NAION (nonarteritic anterior ischemic optic, neuropathy) - Hearing loss - Vision loss - Priapism - Hypotension PDE-5 MoA: increases cGMP levels
treprostinil administration Subcutaneous treprostinil is associated with pain at both old and current administration sites in a majority of patients.
Box warning Bosentan (Tracleer) hepatotoxicity and/or increased liver function tests for all ERAs
ERA Boxed warnings - Restricted access programs: embryo-fetal toxicity
epoprostenol (Veletri) The medication is continued without interruptions.
Which PAH medications require a negative pregnancy test before starting and monthly thereafter? All of the endothelin receptor antagonists (ERAs) and riociguat have REMS programs due to the boxed warnings for teratogenicity.
Created by: dao.vo11017
 

 



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