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DM-Acetaminophen

QuestionAnswer
Classification Analgesic, Antipyretic
Action Inhibits prostaglandin synthesis in the central nervous system, reducing pain and fever
Indications Mild to moderate pain
Contraindications (SADO)Severe Liver Dysfunction, Allergy / Hypersensitivity, Dosage, Overdose
Cautions Liver Impairment
Side Effects Adverse reactions are uncommon with short-term use of acetaminophen. Rash and hives are rarely reported, but can occur Nausea and vomiting Constipation can develop with long-term use
Dosage 500-1,000 mg PO (specifically, 15 mg/kg to a maximum of 1,000 mg) May repeat once after 4 hours 24-hour maximum, from all sources and all routes of administration: 4 g (4,000 mg) May be used concurrently with Ibuprofen for analgesia
What is the max dosage if the patient has known liver dysfunction (e.g., advanced chronic liver disease or cirrhosis)? 2g or 2000mg
Route? Per os (By mouth)
Onset, Peak, Duration Onset: 30 minutes Peak: 1-3 hours Duration: 4 hours
Elimination Primarily Renal
What is the Iatrogenic Overdose with Acetaminophen? Toxicity may occur after a single dose of more than 7.5 g in adults or 150 mg/kg in pediatrics.
Paediatric Considerations and Dosing Follow weight-based dosing < 30 kg: 15 mg/kg PO (use liquid preparation) 30-50 kg: 500 mg PO (may use liquid preparation or tablets, depending on patient ability) > 50 kg: 500-1,000 mg PO
When can you repeat the dose with paediatrics? What is the 24-hour maximum? How many doses can you not exceed in 24 hours in patients less than 12? – May repeat once after 4 hours – 24-hour maximum: 75 mg/kg or 1 g (1,000 mg) Do not exceed 5 doses in 24-hours in patients < 12 years of age
Created by: Levelstorm3950
 

 



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