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BMB 4450

Opioids and Endocannabioids

QuestionAnswer
What are the four known types of opioid receptors? u, K, delta, sigma
In the peripheral nervous system (PNS), how do endorphins inhibit the transmission of pain? blocking the release of glutamate and substance P
In the central nervous system (CNC), how do endorphins inhibit the transmission of pain? blocking gamma-aminobutyric acid (GABA), increasing dopamine release
u (mu) opioid receptors are associated with what? relaxation, trust, satisfaction, analgesia
K (kappa) opioid receptors are associate with what? chronic anxiety perceptual mobilization
Delta opioid receptors are associated with what? initiation, impulsivity, behavioral mobilization
What are the 4 stages of opioid usage? rush, high, nod, straight
Metabolization of the drug can occur in the intestine and liver through what? biotransformation (P450/CPR)
What is opioid use disorder? when someone no longer uses opioids for medicinal use
What is Naloxone? an opioid antagonist used to reverse opioid overdose
What type of receptors do cannabinoids bind to? non-opioid receptors
What are two examples of cannabinoids? capsaicin (hot peppers) and THC (marijuanna)
What are endocannabinoids? molecules made within the body that when at high levels, may reduce addictiveness properties of opioids
What are phytocannabinoids? produced by cannabis plant as a defense mechanism
Capsaicin acts on what receptor? TRPV1 on nociceptor fibers
Created by: gracelisabethxo
 

 



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