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genetics final

genetics

TermDefinition
restriction enzymes produced by bacteria as a defense mechanism against bacteriophage infection. Restrict infections by degrading the viral DNA. Binds to DNA at a specific nucleotide sequence and cuts both strands of DNA within the sequence by cleaving phosphodiester bonds.
Fragment Link Joins DNA fragments together using DNA Ligase to glue the backbone together.
RFLP (Restriction Fragment Length Polymorphism) Identifies variation in DNA sequences by cutting DNA into different fragment sizes.
ASO (Allele specific oligonucleotide) specific DNA probes used to detect point mutations, which are SNPs
SNPs They're variations in DNA sequences from person to person. They're short, single stranded and hybridize complementary alleles/sequences.
WGS Whole genome sequencing. Part of personal genomics. Entire genome.
GWAs organizes whole populations. can be graphed.
Xist encodes long noncoding RNA that coats the X chromosome. Results in changes in chromatin structure that SILENCE transcription. Turns off the inactive X chromosome. Recruits PCR2.
Tsix gene transcribed on the active X chromosome. Antisense to Xist. Represses the encoding of Xist on the X chomosome, letting one X chomosome be active.
Jpx gene encodes lncRNA that stimulates the transcription of Xist on the inactive X chromosome. Basiclly activates Xist on the inactive X chromosome.
Xite gene sustains Tsix.
PCR2 proteins produce epigenetic marks that repress transcription, Recruited by Xist.
Created by: 010307
 

 



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