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Week 2
Week 2: Respiratory & Cardiovascular
| Generic | Brand | Drug Class | Side Effects | Common Indication/ Use | BBW | Counseling |
|---|---|---|---|---|---|---|
| Levalbuterol | Xopenex HFA | Selective B2 agonist | Headaches, nervousness, tachycardia, paradoxical bronchospasm | Bronchodilator for asthma | Chamber or spacer is recommended for those with poor technique. Mask for pt <3 or 4 yrs of age | |
| Fluticasone HFA | Flovent HFA or Flovent Diskus | ICS | Nasopharyngitis, candidiasis, respiratory infection | Asthma | Increased risk of pneumonia in some long term studies (>6 months) | Rinse and spit mouth out water. Do not swallow |
| Budesonide | Pulmicort | ICS | Nasopharyngitis, candidiasis, respiratory infection | Asthma | Increased risk of pneumonia in some long term studies (>6 months) | Rinse and spit mouth out water. Do not swallow |
| Montelukast | Singular | Leukotriene receptor antagonist | Various neuropsychiatric adverse reactions, atopic dermatitis, abdominal pain | Allergic rhinitis, asthma | Serious neuropsychiatric events | Monitor for signs of sucidal thinking and aggressive behavior |
| Felodipine | Plendil | Dihydropyridine CCB | Peripheral edema, headache | HTN and Angina | Symptomatic hypotension with or without syncope can rarely occur. Edema (dose dependent ) within 2-3 weeks of therapy CI: grapefruit juice | |
| Quinapril | Accupril | ACE inhibitor | AKI (increased BUN & SCr) resulting in oliguria. Angioedema (high risk in black pt 4-5 fold). Dry mouth, hyperkalemia | HTN and HF | Fetal toxicity | Monitor: BP, BUN,SrCr, K Need to space from sacubitril for 36 hours. |
| Fosinopril | Monopril | ACE inhibitor | AKI (increased BUN & SCr) resulting in oliguria. Angioedema (high risk in black pt 4-5 fold). Dry mouth, hyperkalemia | HTN and HF | Fetal toxicity | Monitor: BP, BUN,SrCr, K Need to space from sacubitril for 36 hours. |
| Candesartan | Atacand | Angiotensin II receptor antagonist (ARB) | Hypotension, altered kidney fxn, hyperkalemia | HTN | Fetal toxicity | Monitor: BP, BUN, SrCr, K |
| Labetalol | Normodyne | A/B adrenergic blocker | Hypotension, nausea, dizziness | HTN and hypertensive emergency | Monitor: BP, HR Continuous cardiac monitoring (IV only), Periodic LFT CI: Severe sinus bradycardia | |
| Nebivolol | Bystolic | Cardioselective B-blocker | Hypotension, dizziness | HTN | Monitor: BP, HR , Serum glucose with diabetes CI: Severe bradycardia, decompensated heart block | |
| Terazosin | Hytrin | A-1 adrenergic Blocker | Orthostatic hypotension, floppy iris syndrome (pt with cataract surgery) | BPH, HTN, stone expulsion | If therapy is D/C for several days, begin with initial dose and re-titrate due to orthostatic hypotension | |
| Tolvaptan | Samsca | Vasopressin antagonist | Increased thirst, dry mouth, diarrhea | Hyponatremia | Initiated and reinitiated in pt only in a hospital where NA can be monitored. Too rapid correction of hyponatremia (12mEq/L per 24 hours) can cause osmotic demyelination, dysarthria, mutism, dysphagia, lethargy | Ingest fluids in response to thirst, D/C in those who have signs and symptoms of hypovolemia CI: CYP3A inhibitors |
| Doxazosin | Carder | A-1 adrenergic Blocker | Orthostatic hypotension, floppy iris syndrome (pt with cataract surgery) | BPH, HTN, stone expulsion | If therapy is D/C for several days, begin with initial dose and re-titrate due to orthostatic hypotension |