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Micro drugs

Drugs/inhibitor Target/inhibits ResultsMechanism
Penicillin β‑lactam antibiotic that targets DD‑transpeptidase
Azoles Bind to 14‑α demethylase, blocking the removal of a methyl group from lanosterol Accumulation of toxic sterol intermediates and reduced ergosterol levels
Allylamines Inhibit squalene epoxidase, preventing the oxidation of squalene to squalene‑epoxide Build‑up of squalene and depletion of downstream sterols, leading to membrane instability target squalene epoxidase. This enzyme is responsible for converting squalene into squalene-epoxide, a crucial step in the ergosterol biosynthesis pathway.
Polyenes binds directly to Ergosterol Binds directly, forming pores that increase membrane permeability
Nikkomyces Chitin synthase (cell wall) Blocks the addition of N‑acetylglucosamine residues, halting chitin polymerization
Polyoxins Chitin synthase (cell wall) Competitive inhibition of the enzyme’s active site
Created by: user-1770701
 

 



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