Name the 3 steps in a metabolic pathway

Reversible, irreversible steps and alternative routes

Describe an anabolic pathway

Small substrate converted to larger product

Describe a catabolic pathway

Larger substrate broken down to smaller product

Describe the differences of anabolic and catabolic pathways in terms of energy production.

Anabolic = requires ATP Catabolic = Releases ATP

Describe the function of pores and pumps in the membrane

pores = diffusion pumps = active transport

State the affinity of the substrate and product for an enzyme's active site

substrate = high affinity product = low affinity

Explain the importance of the product having a lower affinity for the active site

It leaves the active site allowing the enzyme to be reused and another substrate to bind

Name the 3 types of enzyme inhibitors

1. competitive 2. non competitive 3. feedback

Define feedback inhibiton

When the end product reaches a critical concentration and blocks an earlier enzyme stopping its own synthesis

Define competitive inhibiton

Binds to the active site and prevents substrate from binding

Define non competitive inhibition

Binds away from the active site but changes the shape of the active site preventing the substrate from binding

Define the affinity of competitive and non compettive inhibitors for the active site

Competitive = high affinity Non competitive = low affinity

Explain why non competitive inhibition is not reversible with increasing substrate concentration

The active site has become destroyed and it cant bind to the substrate

When the active site changes shape after the substrate binds.

When inhibiting a metabolic pathway state which molecule increases and decreases

The molecule before inhibiton increases and any molecule after cannot be made

Explain how to promote the forward reaction in a reversible reaction

Increase substrate concentration OR reduce product concentration

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Metabolic pathways

Question	Answer
Name the 3 steps in a metabolic pathway	Reversible, irreversible steps and alternative routes
Describe an anabolic pathway	Small substrate converted to larger product
Describe a catabolic pathway	Larger substrate broken down to smaller product
Describe the differences of anabolic and catabolic pathways in terms of energy production.	Anabolic = requires ATP Catabolic = Releases ATP
Describe the impact of enzymes on activation energy	They reduce activation energy
Name the 3 types of proteins in the membrane	1. pores 2. pumps 3. enzymes
Describe the function of pores and pumps in the membrane	pores = diffusion pumps = active transport
State the affinity of the substrate and product for an enzyme's active site	substrate = high affinity product = low affinity
Explain the importance of the product having a lower affinity for the active site	It leaves the active site allowing the enzyme to be reused and another substrate to bind
Name the 3 types of enzyme inhibitors	1. competitive 2. non competitive 3. feedback
Define feedback inhibiton	When the end product reaches a critical concentration and blocks an earlier enzyme stopping its own synthesis
State an advantage of feedback inhibiton	Saves ATP
Define competitive inhibiton	Binds to the active site and prevents substrate from binding
Define non competitive inhibition	Binds away from the active site but changes the shape of the active site preventing the substrate from binding
Which type of inhibitor resembles the shape of the substrate	Competitive
Define the affinity of competitive and non compettive inhibitors for the active site	Competitive = high affinity Non competitive = low affinity
Which type of inhibition is reversible with increasing substrate concentration	Competitive
Explain why non competitive inhibition is not reversible with increasing substrate concentration	The active site has become destroyed and it cant bind to the substrate
Define induced fit	When the active site changes shape after the substrate binds.
When inhibiting a metabolic pathway state which molecule increases and decreases	The molecule before inhibiton increases and any molecule after cannot be made
Explain how to promote the forward reaction in a reversible reaction	Increase substrate concentration OR reduce product concentration

Created by: brightminds

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