Moderate–severe disease or failure of systemic therapy

Topical steroids use in psoriasis?

Short-term high potency (book doesn't specify which drugs specifically)

Topical steroids can be used wit other agents?

Yes, can be monotherapy or in combo

Counseling on how to use calcipotriene

Avoid face, axilla (armpit), and groin Shake well before use

Tapinarof class and brand?

Non-steroidal topical agent, Vtama is the brand

Skin irritation, photosensitivity, stained clothing

Zithrol, keratolytic irritant, prevents rapid cell growth and inflammation

Acitretin Boxed warnings and major ADRs?

Box warning: CI pregnancy Hepatotoxicity

Major ADRs of Apremilast?

Weight loss, depression/suicide Diarrhea/nausea

Which drugs fall into the IL inhibitors class?

Brodalumab (Siliq), Bimekizumab (Bimzelx), Guselkumab (Tremfya), Ixekizumab (Taltz), Risankizumab (Skyrizi), Secukinumab (Cosntyx)

Majors risks for IL inhibitors?

Serious infections, including TB (need to screen for TB prior to use)

Common ADRs in IL inhibitors?

Diarrhea, URTI (upper resp tract infection)

What is the general tx protocol for psoriasis?

Start with topical options, then topical calcineurin inhibitors, then systemic immunosuppressants like MTX or cyclosporin

Cyclosporin warnings/ADRs?

HTN, nephrotoxicity, tremors, gingival hyperplasia

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RxPrep

Psoriasis

Question	Answer
First line therapy for mild psoriasis?	Topical therapy
When use systemic therapy?	Moderate–severe psoriasis
When use biologics?	Moderate–severe disease or failure of systemic therapy
Non-drug therapy for mild–moderate psoriasis?	UV phototherapy
Topical steroids use in psoriasis?	Short-term high potency (book doesn't specify which drugs specifically)
Why limit topical steroids	Risk of adverse effects
Topical steroids can be used wit other agents?	Yes, can be monotherapy or in combo
Calcipotriene brand names?	Dovonex, Sorilux
Calcipotriene class?	Vitamin D analog
Calcipotriene contraindication?	hypercalcemia
Counseling on how to use calcipotriene	Avoid face, axilla (armpit), and groin Shake well before use
Tapinarof class and brand?	Non-steroidal topical agent, Vtama is the brand
Tapinarof common ADRs?	Folliculitis, dermatitis
Counseling on tapinarof?	Wash hands after use
Coal tar ADRs?	Skin irritation, photosensitivity, stained clothing
Tazarotene class and brand?	Topical retinoid, Tazorac
What is anthralin?	Zithrol, keratolytic irritant, prevents rapid cell growth and inflammation
Which systemic retinoid is used for psoriasis?	Acitretin
Acitretin Boxed warnings and major ADRs?	Box warning: CI pregnancy Hepatotoxicity
When is acitretin indicated for psoriasis?	Only in severe psoriasis
Apremilast class and brand?	PDE-4 inhibitor, Otezla
Major ADRs of Apremilast?	Weight loss, depression/suicide Diarrhea/nausea
Which drugs fall into the IL inhibitors class?	Brodalumab (Siliq), Bimekizumab (Bimzelx), Guselkumab (Tremfya), Ixekizumab (Taltz), Risankizumab (Skyrizi), Secukinumab (Cosntyx)
Majors risks for IL inhibitors?	Serious infections, including TB (need to screen for TB prior to use)
Which psoriasis drugs can cause suicidality?	Apremilast, brodalumab (Siliq)
Common ADRs in IL inhibitors?	Diarrhea, URTI (upper resp tract infection)
Which drugs fall into the TYK2 inhibitors?	Deucravacitinib (Sotyku)
Major risks of TYK2?	Infection, avoid live vaccines
What is the general tx protocol for psoriasis?	Start with topical options, then topical calcineurin inhibitors, then systemic immunosuppressants like MTX or cyclosporin
Cyclosporin warnings/ADRs?	HTN, nephrotoxicity, tremors, gingival hyperplasia

Created by: cdaughtry

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