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Seminar

Oncology

QuestionAnswer
Alkylating Agents Inhibit DNA and protein synthesis resulting in cell death
Cyclophosphamide Hemorrhagic Cystitis Only with HIGH doses administer Mesna
Ifosfamide Hemorrhagic Cystitis Always administer with Mesna
Busulfan Pulmonary Toxicity Neurotoxicity: Seizures
Cyclophosphamide Alkylating Agent
Ifosfamide Alkylating Agent
Busulfan Alkylating Agent
Carmustine Pulmonary Toxicity Neurotoxicity: Seizures
Carmustine Alylating Agent
Platinum Based Compounds Cross link DNA interfering with DNA synthesis and cell replication resulting in cell death.
Cisplatin Platinum Based Compound
Cisplatin Hypersensitivity Reactions Nephrotoxicity (Amifostene)- Limit to <100 mg/m2 per cycle Ototoxicity Peripheral Neuropathy
Oxaliplatin Platinum Based Compound
Oxaliplatin Hypersensitivity Reactions Nephrotoxicity Ototoxicity Peripheral Neuropathy- EXACERBATED BY COLD
Carboplatin Hypersensitivity Reactions Nephrotoxicity Ototoxicity Peripheral Neuropathy
Anthracyclines Intercalation into DNA, Inhibit Topoisomerase II and create oxygen free radicals that damage cells.
Doxorubicin Anthracycline
Mitoxanthrone Anthracycline
Doxorubicin Cardiotoxicity- GIVE Dexrazoxane, Total Lifetime Dose 450-550 mg/m2 Red Discoloration
Mitoxanthrone Blue Discoloration
Carboplatin Platinum Based Compound
Topoisomerase I Inhibitors Inhibit the coiling and uncoiling of double stranded DNA in the S phase preventing religation
Irinotecan Topoisomerase I Inhibitor
Irinotecan Acute Diarrhea Cholinergic Symptoms
Irinotecan Topoisomerase I Inhibitor
Irinotecan Acute Diarrhea (< 24 hours) Atropine
Irinotecan Delayed Diarrhea (> 24 hours) Loperamide
Topoisomerase II Inhibitors Inhibit the coiling and uncoiling of double stranded DNA in the G2 phase
Etoposide Topoisomerase II Inhibitor
Vinca Alkaloids Inhibit microtubule formation during the M phase of cell cycle
Vincristine Vinca Alkaloid
Vinblastine Vinca Alkaloid
Vincristine Peripheral Neuropathy- Limit doses to 2 mg Autonomic Neuropathy (Constipation) DO NOT GIVE INTRATHECALLY DEATH
Vinblastine Peripheral Neuropathy Autonomic Neuropathy (Constipation) DO NOT GIVE INTRATHECALLY DEATH
Taxanes Inhibit depolymerization of tubulin during the M phase of the cell cycle
Taxanes Use a 0.22 micron filter and non-PVC bag and tubing
Paclitaxel Peripheral Neuropathy Hypersensitivity Reaction- Premedicate
Doceltaxel Peripheral Neuropathy Hypersensitivity Reaction- Premedicate SEVERE FLUID RETENTION
Paclitaxel Taxane
Doceltaxel Taxane
Pyrimidine Analog Antagonists Inhibit Pyrimidine DNA synthesis during the S phase
5-FU Pyrimidine Analog Antagonists
Capecitabine Pyrimidine Analog Antagonists
5-FU HFS Diarrhea Mucositis DPD Deficiency- Increase Toxicity INCREASE INR
5-FU and Capecitabine Antidote Uridine Triacetate
Folate Antagonists Interfere with the enzymes involved in the folic acid cycle, blocking purine and pyrimidine synthesis in the S phase
Methotrexate Folate Antagonists
Methotrexate Nephrotoxicity HIGH DOSES GI Toxicity
Methotrexate Rescue MTX > 500 mg/m2 Leucorvin
Antidote MTX Overdose Glucarpidase
Created by: lvilla55
 

 



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