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hematology exam 4
| Question | Answer |
|---|---|
| primary function of neutrophils | phagocytosis |
| what pools of neutrophils are included in the marginal neutrophil pool (MNP) | only cells loosely localized to the vessel walls |
| what is the last granulocyte in the maturation sequence able to undergo mitosis? | myelocyte |
| mature mast cells are | tissue effector cells |
| what directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow | colony-stimulating factor cytokines |
| what is the earliest morphologically identifiable cell in the granulocyte maturation sequence? | myeloblast |
| a cell having a round nucleus with delicate chromatin, two to four prominent nucleoli, and a high N:C ratio of 8:1 with scant basophilic cytoplasm is an accurate description of | myeloblast |
| what is the earliest stage of maturation where a neutrophil can be distinguisged from an eosinophil | myelocyte |
| what is the correct maturation sequence for granulocytes | myeloblast, promyelocyte, myelocyte, metamyelocyte, band, segmented |
| what neutrophil is capable of chemotaxis | seg |
| what cell has the most controversial morphologic identification system? | bands |
| feature of a normal segmented neutrophil | small pink-lilac granules |
| functions performed by segmented neutrophils | chemotaxis, phagocytosis, pinocytosis |
| response to parasitic infections is associated with an increase of which type of granulocyte | eosinophil |
| large cell with abundant blue-grey cytoplasm containing minute granules, lacy or stringy chromatin, and an indented or folded nucleus | monocyte |
| when monocytes reside in tissues they are referred to as | macrophages |
| what cells are normally produced in multiple sites including the bone marrow, thymus and spleen | lymphocytes |
| what cells are responsible for antibody production | plasma cells |
| B and T cells are subgroups of what cell type | lymphocytes |
| why is the bones marrow (storage) pool of granulocytes so large compared with the total number found in peripheral blood | they can be quickly released when needed to fight infection |
| how many circulating platelets are produced from a single megakaryocyte | 2000-4000 |
| from where are additional platelets first derived when the circulating count decreases | spleen |
| what happens to megakaryocytes as they mature | nucleus becomes polyploid |
| how are platelets released into peripheral circulation from bone marrow | megakaryocyte cytoplasmic fragments extend thru the endothelial cells, lining the sinusoids, into blood and then shed platelets |
| how to describe reticulated (stress) platelets | they appear in compensation for thrombocytopenia and their diameter exceeds 6um |
| functions of the platelet surface connected canalicular system (SCCS) | deliver granule contents to the surface, connects the internal contents to the surface, store hemostatic proteins |
| what receptor and protein is needed for adhesion | gpIb/IX/V + VWF |
| what receptor and protein is needed for aggregation | GP IIb/IIIa + fibrinogen |
| what is a liver secreted plasma enzyme that digests "unused VWF" | ADAMTS-13 |
| megakaryocyte membrane markers disappear as differentiation proceeds | CD34 |
| a platelet histogram can be generated using automated hematology analyzers, where frequency is plotted versus platelet volume. when a platelet histogram from a normal patient is examined ... | distribution is log normal with a small population of large platelets |
| phospholipids in the platelet membrane are important for all of the following functions | supply of arachidonic acid, receptor for plasma coag enzymes, forms part of the platelet glycocalyx |
| what system is the control center for platelet activation | dense tubular system |
| platelet agonists are substances that | activate platelets |
| what substance is stored in dense granules | serotonin |
Created by:
kingsleya27