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Action Potentials

Chapter 11 - A & P Lecture

QuestionAnswer
primary way nerons communicate: action potentials
action potentials: rapid changes in membrane potential that occur when graded potentials summate at trigger zone and reach threshold
all or none principle: once threshold is reached an action potential will occur regardless of stimulus strength
4 phases of action potentials 1) depolarization 2) repolarization 3) afterpotential (hyperpolarization) 4) return to resting membrane potential
voltage gated ion channels function in action potentials: regulate ion movement across membrane + essentail for generationing action potentials
ex. of voltage gated ion channels in action potentials: sodium channels & potassium channels
steps of voltage gated ion channel activity: 1) resting membrane potential 2) depolarization 3) repolarization 4) end of repolarization 5) afterpotential (hyperpolarizaiton) 6) return to resting membrane potential
resting membrane potential: Na⁺ activation gates are closed; inactivation gates are open K⁺ channels are closed Outside of membrane is more positive than inside
depolarization: Na⁺ activation gates open → Na⁺ enters cell K⁺ channels begin to open Positive-feedback cycle: more Na⁺ entry → more channels open
repolarization: Na⁺ inactivation gates close → Na⁺ entry stops K⁺ channels open → K⁺ exits cell
end of repolarization: Na⁺ activation gates close, inactivation gates reopen Resting configuration restored
afterpotential (hyperpolarization): K⁺ channels stay open longer than needed Extra K⁺ leaves → membrane becomes more negative than resting
return to resting membrane potential: K⁺ channels close Sodium-potassium pump restores resting conditions
refractory period: time where a neuron's ability to respond to a stimulus is reduced
types of refractory periods: absolute & relative
absolute refractory period: - no 2nd action potential can occur - from beginning of aLP to near end of repolarization
relative refractroy period: stronger than threshold stimulus required
Action Potential Frequency: The number of action potentials generated per unit time in response to a stimulus.
Stimulus Strength Categories: 1) Subthreshold 2) Threshold 3) Submaximal 4) Maximal 5) Supramaximal
Subthreshold: cannot trigger AP
Threshold: just enough to trigger AP
Submaximal: between threshold and maximum
Maximal: produces highest AP frequency
Supramaximal stronger than maximal, no increased frequency
Stronger stimuli → higher frequency, not larger AP
Maximum frequency limited by... absolute refractory period
Higher frequency is interpreted as... a stronger signal
Propagation of Action Potentials: The movement of an action potential along an axon
Types of Conduction: Continuous conduction (unmyelinated axons) & Saltatory conduction (myelinated axons)
Continuous conduction: Local currents depolarize adjacent membrane One-way conduction due to refractory period
Saltatory conduction: Action potentials “jump” between nodes of Ranvier Faster due to myelin insulation
Speed of Conduction: The rate at which an action potential travels along an axon
Factors Affecting Speed: Myelination (faster with myelin) Thickness of myelin sheath Axon diameter (larger = faster due to more channels and surface area)
Nerve Fiber Types: Type A, Type B, Type C
Type A large, myelinated (15–120 m/s) Skeletal motor and most sensory neurons
Type B medium, lightly myelinated (3–15 m/s) Autonomic nervous system (ANS)
type C small, unmyelinated (≤ 2 m/s) ANS
 

 



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