click below
click below
Normal Size Small Size show me how
Action Potentials
Chapter 11 - A & P Lecture
| Question | Answer |
|---|---|
| primary way nerons communicate: | action potentials |
| action potentials: | rapid changes in membrane potential that occur when graded potentials summate at trigger zone and reach threshold |
| all or none principle: | once threshold is reached an action potential will occur regardless of stimulus strength |
| 4 phases of action potentials | 1) depolarization 2) repolarization 3) afterpotential (hyperpolarization) 4) return to resting membrane potential |
| voltage gated ion channels function in action potentials: | regulate ion movement across membrane + essentail for generationing action potentials |
| ex. of voltage gated ion channels in action potentials: | sodium channels & potassium channels |
| steps of voltage gated ion channel activity: | 1) resting membrane potential 2) depolarization 3) repolarization 4) end of repolarization 5) afterpotential (hyperpolarizaiton) 6) return to resting membrane potential |
| resting membrane potential: | Na⁺ activation gates are closed; inactivation gates are open K⁺ channels are closed Outside of membrane is more positive than inside |
| depolarization: | Na⁺ activation gates open → Na⁺ enters cell K⁺ channels begin to open Positive-feedback cycle: more Na⁺ entry → more channels open |
| repolarization: | Na⁺ inactivation gates close → Na⁺ entry stops K⁺ channels open → K⁺ exits cell |
| end of repolarization: | Na⁺ activation gates close, inactivation gates reopen Resting configuration restored |
| afterpotential (hyperpolarization): | K⁺ channels stay open longer than needed Extra K⁺ leaves → membrane becomes more negative than resting |
| return to resting membrane potential: | K⁺ channels close Sodium-potassium pump restores resting conditions |
| refractory period: | time where a neuron's ability to respond to a stimulus is reduced |
| types of refractory periods: | absolute & relative |
| absolute refractory period: | - no 2nd action potential can occur - from beginning of aLP to near end of repolarization |
| relative refractroy period: | stronger than threshold stimulus required |
| Action Potential Frequency: | The number of action potentials generated per unit time in response to a stimulus. |
| Stimulus Strength Categories: | 1) Subthreshold 2) Threshold 3) Submaximal 4) Maximal 5) Supramaximal |
| Subthreshold: | cannot trigger AP |
| Threshold: | just enough to trigger AP |
| Submaximal: | between threshold and maximum |
| Maximal: | produces highest AP frequency |
| Supramaximal | stronger than maximal, no increased frequency |
| Stronger stimuli → | higher frequency, not larger AP |
| Maximum frequency limited by... | absolute refractory period |
| Higher frequency is interpreted as... | a stronger signal |
| Propagation of Action Potentials: | The movement of an action potential along an axon |
| Types of Conduction: | Continuous conduction (unmyelinated axons) & Saltatory conduction (myelinated axons) |
| Continuous conduction: | Local currents depolarize adjacent membrane One-way conduction due to refractory period |
| Saltatory conduction: | Action potentials “jump” between nodes of Ranvier Faster due to myelin insulation |
| Speed of Conduction: | The rate at which an action potential travels along an axon |
| Factors Affecting Speed: | Myelination (faster with myelin) Thickness of myelin sheath Axon diameter (larger = faster due to more channels and surface area) |
| Nerve Fiber Types: | Type A, Type B, Type C |
| Type A | large, myelinated (15–120 m/s) Skeletal motor and most sensory neurons |
| Type B | medium, lightly myelinated (3–15 m/s) Autonomic nervous system (ANS) |
| type C | small, unmyelinated (≤ 2 m/s) ANS |