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hemostasis exam 2
| Question | Answer |
|---|---|
| protime reference range | 10-13 seconds |
| what therapeutic anticoagulant is monitored with PT and how does it work? | Coumadin (warfarin) reduces activity of vitamin K dependent factors II, VII, IX, X |
| if a patient is on a therapeutic anticoagulant, how many times normal should the PT be? | 1.5-2.5x normal |
| what factor prolongs PT but does not affect PTT | VII |
| What is the correct term to describe a platelet count of 550 109/L when all other complete blood count (CBC) results are basically normal? | thrombocytosis |
| Chemotherapy results in which of the following? | acquired hypoplastic thrombocytopenia |
| What is the single most common cause of clinically important bleeding? | thrombocytopenia with a platelet count less than 100 109 /L |
| Which of the following results in ineffective thrombopoiesis? | disseminated intravascular coagulation (DIC) |
| A 28-year-old woman sees her family physician complaining of easy bruising and menorrhagia. She has a platelet count of 60 109/L. All other tests are normal. She has a platelet-associated immunoglobulin G (IgG) autoantibody in her serum. | chronic immune thrombocytopenic purpura |
| Which of the following patient groups is most commonly diagnosed with acute immune thrombocytopenic purpura? | children after having an infection |
| Which of the following is a commonly used drug that can cause thrombocytopenia | heparin |
| What kind of antibody causes neonatal alloimmune thrombocytopenia | maternal antibody against a fetal platelet antigen inherited from the father |
| a 4yr old becomes very sick after eating undercooked ground beef. kidney function tests are elevated. thrombocytopenia is mild and a few schistocytes are on the blood film. what is the most likely diagnosis? | hemolytic uremic syndrome |
| what can be treated with plasmapheresis | thrombotic thrombocytopenic purpura |
| a patient has anemia, schistocytes, and thrombocytopenia. The PT and PTT are elevated and the fibrinogen is low. what test to confirm what diagnosis would be appropriate | D dimer to confirm acute DIC |
| whats a distribution related quantitative platelet disorder | splenomegaly |
| what test are best to distinguish thrombotic thrombocytopenic purpura from DIC when a patient has schistocytes | PT and PTT |
| a patient has a PLT count of 650x10^9. other hematology tests are normal. no evidence of hemostasis failure exists. what is most likely | reactive thrombocytosis |
| 23 yr old man has a motorcycle accident. he has abdominal trauma, including a ruptured spleen which he has removed. two weeks after the surgery, his PLT count peaks at 950x10^9. what is most likely | post splenectomy thrombocytosis |
| petechiae, purpura, and ecchymoses all describe | varying size hemorrhages into the skin because of small vessel bleeding |
| what is the most common infectious cause of congenital neonatal megakaryocytic hypoplasia | cytomegalovirus |
| what is believed to be the cause for acute immune thrombocytopenia purpura in children | nonspecific binding of immune complexes to the platelet membrane after a viral illness |
| what is the most serious clinical consequence of heparin induced thrombocytopenia | thrombosis |
| an enzyme linked immunosorbent assay (ELISA) with platelet factor 4 (PF4) coated to the surface of microplate wells is used for the diagnosis of | heparin induced thrombocytopenia |
| what is the probable cause for thrombotic thrombocytopenic purpura | deficiency of a metalloprotease needed to enzymatically degrade unusually large VWF multimers |
| what are the primary clinical manifestations of essential thrombcytopenia | platelet dysfunction, hemorrhage, thrombosis |
| qualitative platelet disorders and vascular disorders typically exhibit | superficial bleeding |
| disorder with absent platelet glycoprotein Ib/IX/V and in which the patient has moderate thrombocytopenia, large platelets and normal aggregometry with all agents except ristocetin | bernard soulier syndrome |
| diagnosis for a patient with a normal platelet count and no aggregation with any agent except ristocetin | glanzmann thrombasthenia |
| what is the most common cause of acquired platelet dysfunction | drugs (aspirin) |
| what stays normal in a patient taking aspirin | platelet count |
| what type of hemostatic complications are found in patients with myeloproliferative disorders? | thrombotic, hemorrhagic, abnormal platelet function |
| What is the mechanism for the platelet dysfunction in multiple myeloma and Waldenström macroglobulinemia? | platelets are coated with paraprotein |
| testing for the diagnosis of vascular disorders | do not have abnormal clinical laboratory tests |
| 78 yr old patient has dark blotches on forearms and backs of hands and bruises easily. he has no other symptoms and all lab tests are normal. what is most likely? | senile purpura |
| clopidogrel (plavix) is a drug used therapeutically for patients with a risk of arterial thrombi because it | inhibits platelet function |
| what is the principle of the KC1Δ analyzer? | Electromechanical clot detection system |
Created by:
kingsleya27