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BMB 4450

Lipid Metabolism and Blood Lipid Profile

QuestionAnswer
Lipid derivatives of what are hydrolysable? glycerol and sphingosine
Lipid derivatives of what are nonhydrolysable? cholesterol
Transportation of fats: pancreatic ______ -> intestinal absorption -> resynthesized TAGS -> ____________ lipase, chylomicrons
Why are HDLs considered "good cholesterol"? HDL helps remove excess lipids from blood and tissues and play roles in returning excess cholesterol to the liver for reuse
What component of chylomicrons is the highest? TAGs
What component of LDLs is the highest? cholesterol
What component of HDLs is/are the highest? proteins and phospholipids
When chylomicrons enter capillaries, what enzyme with bind to them and hydrolyze TAGs into glycerol and free fatty acids? lipoprotein lipase
What happens to the free fatty acids hydrolyzed from chylomicrons? some are absorbed and some bind to albumin to travel elsewhere
After chylomicrons decrease in size, they become IDLs. Where do the IDLs go? liver
What are the steps of cholesterol transport? 1. cholesterol from liver is packaged in VLDLs 2. VLDLs are hydrolyzed in capillaries, leaving TAGs and IDLs 3. IDLs can either enter the liver or be further processed into LDLs 4. LDLs will interact with LDL receptors
What two enzymes are important for the uptake and biosynthesis of cholesterol? HMG-CoA reductase and ACAT
What is ketosis? increased levels of ketone bodies in the blood
What is ketoacidosis? decreased in blood pH due to accumulation of acetoacetate and beta-hydroxylbutyrate
What is the difference between the structures of acetoacetate and beta-hydroxylbutyrate? beta-hydroxylbutyrate only has one carbonyl group
Created by: gracelisabethxo
 

 



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