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Infectious Disease 4

CATEGORYGENERIC NAMEBRAND NAMEINDICATIONSSIDE EFFECTSUS BOXED WARNINGSOTHER NOTES
Allylamine Antifungal Terbinafine (PO, topical) Lamisil (Topical:OTC) Onychomycosis Nausea, abdominal pain, diarrhea, elevated hepatic transaminases, headache
Azole Antifungal Fluconazole (PO, IV) Diflucan Vulvovaginal candidiasis, oropharyngeal candidiasis, invasive candidiasis Nausea, abdominal pain, diarrhea, QTc prolongation, elevated hepatic transaminases
Azole Antifungal Ketoconazole (PO, topical) Nizoral (topical:OTC) Tinea infections Nausea, abdominal pain, diarrhea, QTc prolongation, elevated hepatic transaminases Serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation have occurred; may cause QTc prolongation and drug interactions leading to QTc prolongation
Polyene Antifungal Nystatin (PO) --- Oropharyngeal candidiasis Phlebitis, diarrhea, vomiting, anemia, fever
Polyene Antifungal Nystatin (Topical) Nystop Cutaneous and mucocutaneous fungal infections Burning, itching Only use oral solutions for thrush
Echinocandin Antifungal Micafungin (IV) Mycamine Invasive candidiasis No major side effects
Glucocorticoid and Azole Antiviral betamethasone + clotrimazole lotrisone Cutaneous fungal infections Burning, itching, dryness, skin atrophy Do not use for diaper dermatitis; adrenal suppression with long-term use over large areas of skin
Neuraminidase Inhibtor Antiviral Oseltamivir (PO) Tamiflu Influenza Nausea, vomiting, neuropsychiatric events (i.e., confusion, delirium, hallucinations) in pediatric patients (rare)
Antiviral Acyclovir (PO, IV) Zovirax Herpes simplex virus Nausea, increased hepatic transaminases, crystalluria Vesicant
Antiviral Valacyclovir (PO) Valtrex Herpes simplex virus Nausea, increased hepatic transaminases, crystalluria Vesicant
Antiviral Nirmatrelvir + ritonavir (PO) Paxlovid COVID-19 Diarrhea, dysgeusia Significant drug interactions; strong CYP3A inhibitor
Antiviral Remdesivir (IV) Veklury COVID-19 Hyperglycemia, renal impairment, bradycardia, increased liver enzymes, hypersensitivity
Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (NRTI) Emtricitabine + tenofovir disoproxil fumarate (PO) Truvada HIV infection, PreP, PEP Decreased bone mineral density, kidney injury, nausea, diarrhea Post treatment acute exacerbation of hepatitis B, risk of drug resistance with use for preexposure prophylaxis
Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (NRTI) and Integrase strand transfer inhibitor (INSTI) Emtricitabine (NRTI) + tenofovir alafenamide (NRTI) + bictegravir (INSTI) (PO) Biktarvy HIV infection Increased serum bilirubin, headache, weight gain, insomnia, diarrhea, nausea Post treatment acute exacerbation of hepatitis B Other Notes: take oral INSTIs 2 hours before or 6 hours after products containing calcium, aluminum, magnesium, or iron
Created by: user-1965876
 

 



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