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ID2 Exam 1
| Drug | Class | Activity | Indication | AE | Relevant notes |
|---|---|---|---|---|---|
| Penicillin G | Natural Penicillin | Good: T. pallidum, Streptococci Poor: everything else (Enterococci is moderate but rarely used) | Syphilis | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | IM/IV |
| Naficillin | Penicillinase- resistant Penicillin | "Good: Streptococci, Staphylococci *MSSA drug of choice* Poor: everything else" | MSSA | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | IV only |
| Piperacillin/Tazobactam (Zosyn) | Acyl Ureidopenicillins | Good: gram negative, gram positive, anaerobes, and active against pseudomonas supp. (includes enterococci, MSSA, streptococci) *broad spectrum* | "Mainly used for complicated and hospital-acquired infections (PNA, SSTI, UTI, GI, etc)" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | DOSE: 3.375-4.5gm IV Q6H |
| Ampicillin | Aminopenicillin | "Good: streptococci, enterococci Moderate: enteric GNR, respiratory gram positive coccobacilli (H.flu, Moraxella) Poor: staphylococci, anaerobes" | "Respiratory tract infections, Otitis media" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | IV only |
| Amoxicillin (Amoxil) | Aminopenicillin | "Good: streptococci, enterococci Moderate: enteric GNR, respiratory gram positive coccobacilli (H.flu, Moraxella) Poor: staphylococci, anaerobes" | "Respiratory tract infections, Otitis media" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | DOSE: 250-500mg PO Q8H |
| Ampicillin/Sulbatam (Unasyn) | Aminopenicillin | "Good: streptococci, MSSA, E.faecalis, M.catarrhalis, H.influenza, E.coli, B.fragilis Poor: MRSA *addition of beta lactamase inhibitor improves penicillin activity against MSSA, enteric gram negative, H.flu/Moraxella, and anaerobes*" | "Respiratory tract infections, Otitis media" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | IV only |
| Amoxicillin/Clavulanic Acid (Augmentin) | Aminopenicillin | "Good: streptococci, MSSA, E.faecalis, M.catarrhalis, H.influenza, E.coli, B.fragilis Poor: MRSA *addition of beta lactamase inhibitor improves penicillin activity against MSSA, enteric gram negative, H.flu/Moraxella, and anaerobes*" | "Respiratory tract infections, Otitis media" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | Dose: 875mg PO BID |
| Cefazolin (Ancef, Kefzol) | 1st gen Cephalosporin | Good: gram positive activity against MSSA and streptococci Poor: everything else | "any MSSA or streptococcal infection as long as pathogen is susceptible (staph and strep high activity)" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | DOSE: 1-2gm IV Q8H |
| Cephalexin (Keflex) | 1st gen Cephalosporin | Good: gram positive activity against MSSA and streptococci Poor: everything else | "any MSSA or streptococcal infection as long as pathogen is susceptible" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | DOSE: 250-500mg PO Q6H |
| Cefuroxime | 2nd gen Cephalosporin: True Cephalosporin | Good: gram positive activity against MSSA and streptococci, increased activity against certain resp gram negative (H.influenza, M.catarrhalis) compared to 1st generation | "upper respiratory tract infections (community acquired)" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | |
| Cefotetan | 2nd gen Cephalosporin: Cephamycin | "Good: improved activity against gram negative and anaerobic organisms (B.fragilis) Poor: lower activity against gram positive organisms compared to 1st generation" | "inpatient intra abdominal infections prophylaxis" | "MTT side chain associated with inhibition of vitamin K production and increased risk of bleeding, disulfiram-like reaction with ethanol ingestion , GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | |
| Ceftriaxone (Rocephin) | 3rd gen Cephalosporin | "Good: better gram negative activity compared to 1st/2nd gen (3rd also has gram neg entero activity), streptococci, many gram negative pathogens Poor: no activity against pseudomonas (moderate MSSA activity but generally not used)" | "Used for a variety of community and hospital aquired infections (CNS, PNS, UTI, SSTI, etc) *drug of choice for many enteric GNR* (mainly gram neg or streptococcal infections)" | "~displaces bilirubin from albumin binding sites, avoid in neonates ~interacts with Ca containing medications to form crystals that precipitate ~biliary sludge with hyperbilirubinemia USE CEFOTAXIME INSTEAD IN NEONATES" | |
| Ceftriaxone (Rocephin) | 3rd gen Cephalosporin | "Good: better gram negative activity compared to 1st/2nd gen (3rd also has gram neg entero activity), streptococci, many gram negative pathogens Poor: no activity against pseudomonas (moderate MSSA activity but generally not used)" | "Used for a variety of community and hospital aquired infections (CNS, PNS, UTI, SSTI, etc) *drug of choice for many enteric GNR* (mainly gram neg or streptococcal infections)" | "~displaces bilirubin from albumin binding sites, avoid in neonates ~interacts with Ca containing medications to form crystals that precipitate ~biliary sludge with hyperbilirubinemia USE CEFOTAXIME INSTEAD IN NEONATES" | DOSE: 1-2gm IV Q24H |
| Ceftazidime (Fortaz) | 3rd gen Cephalosporin | "Good: better gram negative activity compared to 1st/2nd gen (3rd also has gram neg entero activity), streptococci, many gram negative pathogens Poor: no activity against pseudomonas (moderate MSSA activity but generally not used)" | "Used for a variety of community and hospital aquired infections (CNS, PNS, UTI, SSTI, etc) *drug of choice for many pseudomonal* (mainly gram neg, or pseudomonal infections)" | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | IV |
| Cefdinir (Omnicef) | 3rd gen Cephalosporin | "Good: better gram negative activity compared to 1st/2nd gen (3rd also has gram neg entero activity), streptococci, many gram negative pathogens Poor: no activity against pseudomonas (moderate MSSA activity but generally not used)" | respiratory infections | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | PO |
| Cefpodoxime (Vantin) | 3rd gen Cephalosporin | "Good: better gram negative activity compared to 1st/2nd gen (3rd also has gram neg entero activity), streptococci, many gram negative pathogens Poor: no activity against pseudomonas (moderate MSSA activity but generally not used)" | PO | ||
| Cefepime (Maxipime) | 4th gen Cephalosporin | "Good: activity against gram negative (pseudomonas, enterobactericiae)(Drug of choice for AmpC producing GNR), activity against gram positive (MSSA, streptococci) Poor: enterococci *broad spectrum*" | "Variety of hospital acquired infections (not usually used to treat MSSA or strep because it is broad spectrum)" | "Neurotoxicity , GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | DOSE: 1-2gm IV Q8-12H |
| Ceftaroline | "Anti-MRSA Cephalosporin" | "Good: activity against gram positive (MSSA, MRSA, streptococci), common enteric and respiratory aerobic gram neg Poor: enterococci, pseudomonas supp." | MRSA (has activity against gram neg but we usually use 3rd gen for gram neg, so this is mainly only used for MRSA) | "GI (N/V, diarrhea), hypersensitivity reaction, hematologic toxicity" | |
| Cefolozane/tazobactam (Zerbaxa) | MDR Pseudomonas, ESBL enteric GNR (but not carbapenemase producing) | ||||
| Imipenem/Cilastatin (Primaxin) | Carbapenems | "*very broad spectrum* Good: most gram pos and gram neg (MSSA, streptococci, enteric/resp gram neg, anaerobes, pseudomonas, acinetobacter supp) Poor: MRSA, enterococci, atypicals" | "hospital acquired infections (SSTI, UTI, PNA, etc) *drug of choice for ESBLs*" | "generally well tolerated, GI (N/V/D) *neurotoxicity and seizures at high doses*" | IV only (resistance to carbapenems can be overcome by adding a beta lactamase inhibitor) |
| Ertapenem (Invanz) | Carbapenems | "*broad spectrum, except pseudo and acinetobacter poor activity* Good: most gram pos and gram neg (MSSA, streptococci, enteric/resp gram neg, anaerobes) Poor: pseudomonas, acinetobacter supp, MRSA, enterococci, atypicals" | "hospital acquired infections (SSTI, UTI, PNA, etc) *drug of choice for ESBLs*" | generally well tolerated, GI (N/V/D) | IV only (resistance to carbapenems can be overcome by adding a beta lactamase inhibitor) |
| Meropenem (Merrem) | Carbapenems | "*very broad spectrum* Good: most gram pos and gram neg (MSSA, streptococci, enteric/resp gram neg, anaerobes, pseudomonas, acinetobacter supp) Poor: MRSA, enterococci, atypicals" | "hospital acquired infections (SSTI, UTI, PNA, etc) *drug of choice for ESBLs*" | generally well tolerated, GI (N/V/D) | IV only (resistance to carbapenems can be overcome by adding a beta lactamase inhibitor) |
| Aztreonam (Azactam) | Monobactam | "Good: only gram neg (enterobactericiae, pseudomonas) Poor: everything else" | "mainly reserved for patients with anaphylaxis to other beta lactams since there is no cross reactivity with aztreonam (except ceftazidime does have cross reactivity)" | generally well tolerated, GI (N/V/D) | IV |
| Doxycycline (Vibramycin) | Tetracyclines | Good: atypicals, MRSA, P.acnes Poor: most streptococci, GNR, anaerobes | atypical pneumonia, MRSA (community acquired), SSTI,lyme disease, acne | GI (N/V/D), bind to multivalent cations=decreases oral absorption (avoid w/ supplements), avoid in kids <8yrs= permanent tooth discoloration (can give short duration <21 days), not recommended in pregnancy= teeth staining, enamel hypoplasia in fetus | IV, PO |
| Minocycline (Minocin) | Tetracyclines | Good: atypicals, MRSA, P.acnes Poor: most streptococci, GNR, anaerobes | atypical pneumonia, MRSA (community acquired), SSTI,lyme disease, acne | GI (N/V/D), bind to multivalent cations=decreases oral absorption (avoid w/ supplements), avoid in kids <8yrs= permanent tooth discoloration (can give short duration <21 days), not recommended in pregnancy= teeth staining, enamel hypoplasia in fetus | IV, PO |
| Tigecycline | Tetracyclines | "*broad spectrum* Good: atypicals, MRSA, P.acnes, VRE, ESBL, anaerobes Poor: most streptococci, GNR, anaerobes" | atypical pneumonia, MRSA (community acquired), SSTI,lyme disease, acne | higher risk of death, should only be used if no other treatments are available, N/V | IV only |
| Azithromycin (Zpak, Zithromax) | Macrolide | "Good: atypicals, H.influenza, Moraxella catarrhalis Poor: staphylococci, enterococci, most GNR, anaerobes" | "respiratory infections, gonorrhea, chlamydia, H. Pylori" | "GI, prolonged QTc, hepatotoxicity, drug interactions (less ddi than clarithromycin)" | "PO, IV DOSE: 500mg PO/IV on day 1, 250mg PO/IV on day 2-5" |
| Erythromycin | Macrolide | "Good: atypicals, H.influenza, Moraxella catarrhalis Poor: staphylococci, enterococci, most GNR, anaerobes" | not really used | "GI, prolonged QTc, hepatotoxicity, drug interactions" | |
| Clarithromycin (Biaxin) | Macrolide | "Good: atypicals, H.influenza, Moraxella catarrhalis Poor: staphylococci, enterococci, most GNR, anaerobes" | H. Pylori | "GI, prolonged QTc, hepatotoxicity, drug interactions (a lot more ddi than azithromycin)" | PO only |
| Ciprofloxacin (Cipro) | Quinolone | "Good: enterobactericiae, pseudonoma, atypical Poor: MRSA, strep pneumoniae, anaerobes Only one that doesn’t cover strep pneumoniae, Only one that doesn’t cover anaerobes" | UTI, intraabdominal infection | BBW: risk of tendinitis/tendon rupture (achilles) elderly, corticosteroid use, solid organ transplant pt, QT prolongation, neurologic (dizzy, HA, insomnia, seizure), DDI w/ PO multivalent cations (avoid concomitant use) and warfarin (increased INR) | "IV, PO DOSE: 250-750mg PO BID; 400mg IV Q8-12H" |
| Levofloxacin (Levaquin) | Quinolone | "Good: strep pneumoniae, enterobactericiae, pseudonoma, atypical Poor: MRSA (moderate anaerobe activity)" | "respiratory infections, UTI, intraabdominal infection" | BBW: risk of tendinitis/tendon rupture (achilles) elderly, corticosteroid use, solid organ transplant pt, QT prolongation, neurologic (dizzy, HA, insomnia, seizure), DDI w/ PO multivalent cations (avoid concomitant use) and warfarin (increased INR) | "IV, PO DOSE: 250-750mg IV/PO QD" |
| Moxifloxacin (Avelox) | Quinolone | "Good: strep pneumoniae, enterobactericiae, atypicals, anaerobes Poor: MRSA, pseudomonas Only one that doesn't cover pseudomonas" | "respiratory infections, intraabdominal infection" | BBW: risk of tendinitis/tendon rupture (achilles) elderly, corticosteroid use, solid organ transplant pt, QT prolongation, neurologic (dizzy, HA, insomnia, seizure), DDI w/ PO multivalent cations (avoid concomitant use) and warfarin (increased INR) | "IV, PO *avoid moxi in UTI because it is not renally cleared*" |
| Delafloxacin (Baxdela) | Quinolone | "Good: MRSA, strep pneumoniae, enterobactericiae, pseudonoma, atypical, MRSA Only one that covers MRSA" | "respiratory infections, intraabdominal infection" | BBW: risk of tendinitis/tendon rupture (achilles) elderly, corticosteroid use, solid organ transplant pt, QT prolongation, neurologic (dizzy, HA, insomnia, seizure), DDI w/ PO multivalent cations (avoid concomitant use) and warfarin (increased INR) | IV, PO |
| "Sulfamethoxazole/ Trimethoprim (Bactrim, Septra, Co-trimoxazole)" | Sulfonamide | "Good: some gram negative (E.coli, stenotrophamonas maltophilia), gram positive (staphylococci, CA-MRSA, MSSA), pneumocyctis jirovecii *HA-MRSA ia resistant to bactrim* Poor: pseudomonas, enterococci, atypicals, anaerobes" | "UTI (dose: 1ds bid), SSTI *drug of choice in: stenotrophamonas maltophilia, and pneumocyctis jirovecii*" | "avoid in sulfa allergic pt, dermatologic (rash, skin photosensitivity), pancytopenia (leukopenia, thrombocytopenia, hemolytic anemia; dose dependent), ddi with warfarn (increased INR)" | "IV, PO DOSE (single strength): 400mg SMX/80mg TMP DOSE (double strength): 800mg SMX/160mg TMP *dosing is based on trimethoprim component)" |
| Clindamycin (Cleocin) | Lincosamide | Good with anaerobes except C.diff, good with streptococci, staphylococci (including CA MRSA) *HA-MRSA is resistant* No activity against aerobic gram neg, enterococci, and atypicals | "SSTI, anaerobic infections" | "*Block Box warining: worsens C.diff* GI (N/V/D)" | "PO, IV DOSING: 300-450mg PO Q6-8H" |
| Metronidazole (Flagyl) | Nitromidazole | "Good: anaerobes (bacteroids sp, prevotella sp, fusobacterium sp, clostridium supp, C.diff) Poor: everything else" | anaerobic infections (intraabdominal, second line for C.diff, bacterial vaginosis) | "GI (N/V/D), neurologic (peripheral neuropathy), ddi with warfarin (increased INR), avoid alcohol" | "IV, PO DOSING: 500mg IV/PO Q8-12H" |
| Telavancin | Lipoglycopeptide | "*only active against gram positive bacteria* streptococci, enterococci, staphylococci (includes MRSA)" | only used if there are no other options (if benefit outweighs risk) | BBW: increased mortality compared to vanco, esp w/ renal impairment, risk of nephtotoxicity, pregnancy test for women needed due to teratogenic effects, inference with PT, aPTT, ACT,INR (interferes with lab tests, not platelet aggregation/ coagulation)" | |
| Dalbavancin | Lipoglycopeptide | "*only active against gram positive bacteria* streptococci, enterococci, staphylococci (includes MRSA)" | SSTI | n/a | long acting with t1/2 >200 hours, so pt only needs 1-2 doses to cure infection |
| Oritavancin | Lipoglycopeptide | "*only active against gram positive bacteria* streptococci, enterococci, staphylococci (includes MRSA)" | SSTI | n/a | long acting with t1/2 >200 hours, so pt only needs 1-2 doses to cure infection |
| Daptomycin (Cubicin) | Lipopeptide | very good activity against most gram positive: streptococci, staphylococco (including MRSA), enterococci (including VRE) | "MRSA, VRE (SSTI, UTI, bone/joint, bacteremia) *avoid use in pneumonia (inactivated by lung surfactants), CNS infection*" | "skeletal muscle toxicity (myopathy), elevated creatine kinsae (weekly monitoring)" | IV only |
| Linezolid (Zyvox) | Oxazolidinone | very good activity against most gram positive: streptococci, staphylococco (including MRSA), enterococci (including VRE) | MRSA, VRE, SSTI, PNA | "myelosuppression (generally reversible), peripheral neuropathy, optic neuropathy (generally reversible) *weak reversible MAO inhibitor, not recommended in combo with SSRI, SNRI, TCA due to seratonin syndrome*" | "IV, PO DOSE: 600mg PO Q12H" |
| Tedizolid phosphate (Sivextro) | Oxazolidinone | very good activity against most gram positive: streptococci, staphylococco (including MRSA), enterococci (including VRE) | MRSA, VRE, SSTI, PNA | "myelosuppression (generally reversible), peripheral neuropathy, optic neuropathy (generally reversible) *currently no limitation in combining with serotonergic drugs*" | |
| Amikacin | Aminoglycoside | "Good: gram negative, pseudomonas, synergistic activity against gram positive when used in combo with a cell wall active agent (no activity against gram positive when used as monotherapy) Poor: everything else" | "hospital acquired gram negative infections, mostly used as part of empiric therapy for HAP/VAP, enterococcal endocardits *rarely used as monotherapy unless no other options available*" | Ototoxicity (2-14%; usually irreversible and dose/duration dependent) Nephrotoxicity (5-10%) --> risk factors: elderly, dehydration, ICU, kidney disease, concomitant nephrotoxic drugs, multiple daily dosing, high troughs, longer duration of therapy | IV |
| Gentamicin | Aminoglycoside | "Good: gram negative, pseudomonas, synergistic activity against gram positive when used in combo with a cell wall active agent (no activity against gram positive when used as monotherapy) Poor: everything else" | "hospital acquired gram negative infections, mostly used as part of empiric therapy for HAP/VAP, enterococcal endocardits *rarely used as monotherapy unless no other options available*" | Ototoxicity (2-14%; usually irreversible and dose/duration dependent) Nephrotoxicity (5-10%) --> risk factors: elderly, dehydration, ICU, kidney disease, concomitant nephrotoxic drugs, multiple daily dosing, high troughs, longer duration of therapy | IV |
| Tobramycin | Aminoglycoside | "Good: gram negative, pseudomonas, synergistic activity against gram positive when used in combo with a cell wall active agent (no activity against gram positive when used as monotherapy) Poor: everything else" | "hospital acquired gram negative infections, mostly used as part of empiric therapy for HAP/VAP, enterococcal endocardits *rarely used as monotherapy unless no other options available*" | Ototoxicity (2-14%; usually irreversible and dose/duration dependent) Nephrotoxicity (5-10%) --> risk factors: elderly, dehydration, ICU, kidney disease, concomitant nephrotoxic drugs, multiple daily dosing, high troughs, longer duration of therapy | IV |
| Vancomycin | Glycopeptide | Active against most gram positive aerobic and anaerobic bacteria: staphylococci (including MRSA), streptococci, enterococci (but not VRE) *typically not used for strep due to side effects* | "IV: only used to treat enterococcal or staphylococcal infections PO: C.diff *drug of choice for HA-MRSA*" | Ototoxicity (2-14%; usually irreversible and dose/duration dependent) Nephrotoxicity (5-10%) --> risk factors: elderly, dehydration, ICU, kidney disease, concomitant nephrotoxic drugs, multiple daily dosing, high troughs, longer duration of therapy | "IV, PO *IV and PO are not interchangeable*" |
| "Nitrofurantoin monohydrate/ macrocrystals (Macrobid)" | Nitrofuran | Good activity against gram negative bacteria (mostly E.coli), mostly active agaisnt gram positive bacteria (staphylococci, streptococci, E.faecalis and VRE) | uncomplicated UTI | GI (n/v), pulmonary toxicity (rare) | *used more often due to BID dosing* |
| "Nitrofurantoin macrocrystals (Macrodantin)" | Nitrofuran | Good activity against gram negative bacteria (mostly E.coli), mostly active agaisnt gram positive bacteria (staphylococci, streptococci, E.faecalis and VRE) | uncomplicated UTI | GI (n/v), pulmonary toxicity (rare) | *used less often due to QID dosing* |
| Polymixin B | Polymixins | "Active against most gram negative bacteria (pseudomonas, acinobacter, some enterobactericiae)" | "multi-drug resistant pseudomonas and acinobacter when no alternatives are available (not used often due to adverse effects)" | nephrotoxicity (20-60%, dose dependent), neurotoxicity (reversible), parasthesias, muscle weakness, peripheral neuropathy | IV |
| Colistin (Coly-Mycin M) | Polymixins | "Active against most gram negative bacteria (pseudomonas, acinobacter, some enterobactericiae)" | "multi-drug resistant pseudomonas and acinobacter when no alternatives are available (not used often due to adverse effects)" | nephrotoxicity (20-60%, dose dependent), neurotoxicity (reversible), parasthesias, muscle weakness, peripheral neuropathy | IV |
| Fidaxomicin | n/a | n/a | "C.diff (one of the first line therapies for C.diff, not systemically absorbed)" | n/a | |
| Fosfomycin | n/a | *broad spectrum* (similar to nitrofurantoin) | uncomplicated UTI | n/a | one time dose |
| Bezlotoxumab | n/a | MOA: monoclonal antibody that binds to toxin B produced by C.diff | C.diff | n/a | "*does not kill C.diff directly, use in combo with a C.diff active drug*" |
| Amphotericin B | Polyenes | "Good activity against Candida spp, Aspergillus spp, Mucormycosis, Cryptococcus spp, Cocci immitis *Broad spectrum antifungal with activity against most yeasts/molds*" | use largely reserved for invasive and life threatening fungal infections when no other options are available | Nephrotoxicity: secondary to direct vasoconstriction of afferent renal arterioles, dose related, K and Mg wasting, saline bolus prior to each administration recommended Infusion-related: premedicate with APAP, diphenhydramine, and/or meperidine | "IV ~Conventional Amp B deoxycholate: avoid b/c nephrotoxicity ~Liposomal formulations of Amp B: lower risk of nephrotoxicity *Amp B lipid complex (Abelcet) *Liposomal Amp B (Ambisome) --> less infusion reactions=nephrotoxicity |
| Nystatin | Polyenes | Candida spp. | "suspension mainly used for mild moderate mucocutaneous infections caused by Candida such as thrush" | n/a | "Topical, Suspension *suspension commonly called ""swish and swallow""*" |
| Flucytosine | n/a | "Active against Candida spp, Crptococcus spp *MOA: causes inhibition of DNA and RNA synthesis *" | "part of induction/treatment for cryptococcal meningitis in combo with Amp B (rarely used for anything else, avoid monotherapy due to resistance)" | "GI (N/V/D), bone marrow suppression, hepatotoxicity (TDM recommended to avoid toxicity) *Black Box warning: closely monitor hematologic, renal, and hepatic status*" | |
| "Micafungin (Mycamine), Caspofunfungin (Cancidas), Anidulafungin, Rezafungin" | Echinocandins | Fungicidal against Candida spp (drug of choice for non-albicans species or if speciation still pending in case of invasive candida infections) | mainly used to treat candida infections (generally considered interchangeable) | GI, gnerally well tolerated | "IV *Rezafungin is unique because it is a one time dose*" |
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