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PHO 2
| Category | Generic | Brand | Classification | Indications | SE |
|---|---|---|---|---|---|
| Opiod and nonopiod analgesic combination | hydrocodone and acetaminophen (PO) | Lortab, Vicodin, Norco | CS-II | Pain | SE: Dizziness, sedation, N/V, constipation, itching, resp. depression. BBW: Opioid risks, CYP3A4 interactions increase oxycodone, liver toxicity. |
| Opiod and nonopiod analgesic combination | oxycodone and acetaminophen (PO) | Percocet, Endocet | CS-II | Pain | SE: Dizziness, sedation, N/V, constipation, itching, resp. depression. BBW: Opioid risks, CYP3A4 interactions increase oxycodone, liver toxicity. |
| Opiod and nonopiod analgesic combination | codeine and acetaminophen (PO) | Tylenol with Codeine #3, Tylenol with Codeine #4 | CS-III | Pain | SE: Dizziness, sedation, N/V, constipation, itching, resp. depression. BBW: Opioid risks, CYP interactions, fatal pediatric resp. depression, liver toxicity. |
| Opioid antagonist | naloxone (IV,IM,SQ,Intranasal) | Narcan Nasal Spray Zimhi | Narcan Nasal Spray: OTC | Opioid overdose | Key Side Effects: opioid withdrawal syndrome in opioid-dependent populations, pain |
| Partial opioid agonist and opioid antagonist | buprenorphine and naloxone (SL) | Suboxone | CS-III | Opioid use disorder | SE: Withdrawal, constipation, HA, sweating. Risk: Fatal respiratory depression with CNS depressants. Naloxone deters injection misuse. |
| Iron supplement | ferrous sulfate (PO) | FeroSul, SlowFe | OTC | Iron deficiency anemia | Key Side Effects: nausea, stomach upset, constipation (dose-related), dark and tarry stools US Boxed Warning: accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old |
| Water-soluble vitamin | cyanocobalamin (Vit B12) (PO,IM,SL,Intranasal) | cyanocobalamin (Vit B12) | PO,SL: OTC | Vitamin B12 deficiency (manifest as macrocytic anemia) | Key Side Effects: no major side effects |
| Water-soluble vitamin | folic acid (PO) | folic acid | OTC | Folic acid deficiency (manifest as microcytic anemia,) prevention of neural tube defects in pregnancy | Key Side Effects: no major side effects |