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spears/carv exam 3

12 questions on this slide show

CLASSDRUGMOAADRsNOTESSAR
Immunomodulators (historical - HCV treatment PEG-interferon-alpha 2a (pegasys) or 2b (pegintron binds cell surface interferon receptors , anti viral/antiproliferative and immunomodulatory action influenza like symptoms AND dose limiting TOX of myelosuppression, CNS effects, antoimmune disorders CI in patients with hyperbilirubinemia, PEG makes interferon half life very long, not much used
Nucleoside analogue (adjuctive) - HCV treatment Ribavirin (rebetol, copegus) possibly inhibits HCV polymerase at NS5B opportunistic infections, BOXED WARNING: AVOID as monotherapy (ineffective), hemolytic anemia - leading to MI, and teratogenic avoid in CrCl under 50, avoid using with azathioprine, cardiac, pulmonary, immune, psych, dysfunction or elderly and pediatric is a ribofuranosyl triazole derivative
Inhibitors of -non-stuctural proteins (primary) - direct acting antivirals (DAA) or STAT-C (specifically targeted antiviral therapy for HCV) grazoprevir, elbasvir, sofobuvir (sovaldi)
Combo PI and 5A Mavyret (glecaprevir and pibrentasvir) Zepatier (elbasvir and grazoprevir) do not use with atazanavir or rifampin (PI interaction) Mavyret is taken with food, zepatier is not CI in decomp liver, chirosis test for RAS because fo -avir (5A component)
Combo 5B and5A Epclusa (Sofosbuvir and velpatasvir) Harvoni (ledipasir and sofosbuvir) RAS test for 5A (avirs) use in pts with liver damage because no PI DDI with amiodarone and antacids insomnia and weight gain
Combo 3/4A, 5A and 5B VoSeVi (velpatasvir, sofosbuvir, voxilaprevir) CI in hepatic dysfunction, RAS testing for 5A, CI with rifampin (3/4A), DDI with amiodarone and antacids so this is all the issues of the other ones combined
Created by: beezy41
 

 



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