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Infectious Disease 2
| CATEGORY | GENERIC NAME | BRAND NAME | INDICATIONS | ACTIVITY | SIDE EFFECTS | US BOXED WARNINGS | OTHER NOTES |
|---|---|---|---|---|---|---|---|
| Carbapenem | Meropenem (IV) | Merrem | Meningitis, HAP, DFI, IAI | Pseudomonas aeruginosa, ESBL-producing Enterobacteriaceae | Diarrhea, hypersensitivity, reactions, seizures with excessive doses | ||
| Carbapenem | Ertapenem (IV) | Invanz | DFI, IAI | ESBL-producing Enterobacteriaceae | Diarrhea, hypersensitivity, reactions, seizures with excessive doses | ||
| Fluoroquinolone Antibiotic | Ciprofloxacin (PO, IV) | Cipro | Pyelonephritis, HAP, VAP | Pseudomonas aeruginosa, atypicals, Enterobacteriaceae | QTc prolongation, tendon rupture, increased hepatic transaminases, photosensitivity | May cause serious adverse reactions including tendinitis and tendon rupture, peripheral neuropathy, and CNS effects; may exacerbate muscle weakness in patients with myasthenia gravis | Take oral fluoroquinolones 2 hours before or 6 hours after products containing divalent or trivalent cations; increased risk of aortic dissection or rupture, dysglycemias, CNS side effects |
| Fluoroquinolone Antibiotic | Levofloxacin (PO, IV) | Levaquin | CAP, HAP, VAP, pyelonephritis | Pseudomonas aeruginosa, Streptococcus pneumoniae, atypicals, Enterobacteriaceae | QTc prolongation, tendon rupture, increased hepatic transaminases, photosensitivity | May cause serious adverse reactions including tendinitis and tendon rupture, peripheral neuropathy, and CNS effects; may exacerbate muscle weakness in patients with myasthenia gravis | Take oral fluoroquinolones 2 hours before or 6 hours after products containing divalent or trivalent cations; increased risk of aortic dissection or rupture, dysglycemias, CNS side effects |
| Fluoroquinolone Antibiotic | Moxifloxacin (Oph, PO, IV) | Oph: Vigamox, PO,IV: Avelox | Ophthalmic: bacterial conjunctivitis, PO, IV: CAP | Streptococcus pneumoniae, atypicals, tuberculosis | QTc prolongation, tendon rupture, increased hepatic transaminases, photosensitivity | May cause serious adverse reactions including tendinitis and tendon rupture, peripheral neuropathy, and CNS effects; may exacerbate muscle weakness in patients with myasthenia gravis | Take oral fluoroquinolones 2 hours before or 6 hours after products containing divalent or trivalent cations; increased risk of aortic dissection or rupture, dysglycemias, CNS side effects |
| Macrolide Antibiotic | Azithromycin (PO,IV) | Zithromax, Z-pak, Zmax | CAP | Chlamydia trachomatis, atypicals | Diarrhea, QTc prolongation | ||
| Macrolide Antibiotic | Fidaxomicin (PO) | Dificid | CDI | Clostridioides difficile | Nausea | Do not use for systemic infections (no systemic absorption) | |
| Tetracycline Antibiotic | Doxycycline (PO, IV) | Vibramycin | SSTI, CAP, tickborne diseases | MRSA, atypicals | Esophagitis (doxycycline only), photosensitivity, DILE (minocycline only) | Avoid in children <8 years old, pregnancy, and breastfeeding due to bone growth suppression and teeth discoloration; take oral tetracyclines 2 hours before or 6 hours after products containing divalent or trivalent cations | |
| Tetracycline Antibiotic | Minocycline (PO, IV) | Minocin | SSTI, acne | MRSA | Esophagitis (doxycycline only), photosensitivity, DILE (minocycline only) | Avoid in children <8 years old, pregnancy, and breastfeeding due to bone growth suppression and teeth discoloration; take oral tetracyclines 2 hours before or 6 hours after products containing divalent or trivalent cations |