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Oral Hypoglyemic
| Question | Answer |
|---|---|
| metformin - SE | gi disturbances, rare - lactic acidosis |
| metformin - NC | admin in morning, discontinue 1-2 days before IV contrast |
| glipizide and glyburide- SE | hypoglycemia, weight gain |
| glipizide and glyburide - NC | assess for allergies to sulfa antibiotics, (glip)must be taken on empty stomach |
| repaglinide and nateglinide - SE | hypoglycemia, weight gain |
| repaglinide and nateglinide - NC | before meals, hold if meal is skipped, DONT give with gemfibrozil |
| pioglitazone and rosiflitazone - SE | hypoglycemia with sulfonylurea, muscle weakness/pain, sore throat, UTI |
| pioglitazone and rosiflitazone - NC | DONT give with gemifibrozil, decrease effects of oral contraceptives, CANT give during pregnancy |
| acarbose - SE | flatulence, cramps, abdominal distension, diarrhea |
| acarbose - NC | DONT use with pt with GI problems, need to use glucose tablets to correct hypoglycemia |
| depagliflozin, canaglitflozin, empagliflozin - SE | hypotension, yeast infection, UTI, polyuria, weight loss, kidney damage |
| depagliflozin, canaglitflozin, empagliflozin - NC | can help decrease weight, once a day dose |
| pramlintide - SE (non-insulin injectable) | GI disturbances, can delay absorption of other drugs |
| pramlintide - NC (non-insulin injectable) | give at mealtimes with insulin, DONT mix in the same syringe |
| exenatide - SE (non-insulin injectable) | hypoglycemia if taken with sulonylurea, GI disturbances |
| exenatide - NC (non-insulin injectable) | give 1 hour before meals, used with metformin or sulfonylurea, once weekly injections |
| liraglutide - SE (non-insulin injectable) | GI disturbances, icnreased risk for pancreatitis, pancreatic cancer, and renal failure |
| glucagon and hydrochloride - SE | hyperglyceia, BP changes, tachycardia, GI disturbances (place them on side) |
| glucagon and hydrochloride - NC | monitor for hyperglycemia, educate on how to admin |
| short duration - rapid - meds | lispro, aspart, and gluisine |
| short duration - rapid - action | must go with long or int. insulin, controls after meal rise in BG |
| short duration - rapid - times | onset - 10min-30min peak - 30min-3hr duration - 3hr-6hr |
| short duration - rapid - NC | give WITH meals, clear, SQ or IV, can be used on sliding scale |
| short duration - slower - meds | humulin R novolin R |
| short duration - slower - action | controls after meal rise in BG |
| short duration - slower - times | onset - 30min-1hr peak - 1hr-5hr duration - 6hr-10hr |
| short duration - slower - NC | give BEFORE meals, clear, SQ or IV |
| Intermediate - med | NPH |
| Intermediate - action | controls BG between meals and at night |
| Intermediate - times | onset - 1hr-2hr peak - 6hr-14hr duration - 16hr-24hr |
| Intermediate - NC | cloudy, can be mixed with short acting, SQ, roll before you give, BID |
| long - med | determir and glargine |
| long - action | gives basal control |
| long - times | onset - 1hr-2hr peak - none duration - 12hr-24hr |
| long - NC | determir once/twice daily SQ, can NOT be mixed with other insulin, clear, (glargine) once SQ (usually HS) |