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Acid Release
| Acid Release Mediators | Released by | Effects | Type |
|---|---|---|---|
| Acetylcholine (ACh) | Released by sight, smell, taste, or ingestion of food | ↑Histamine (ECL), ↑ H+ (Parietal), ↓ Somatostatin (D) | Activator |
| Gastrin | Released by dietary peptides, stimulation of GRP-R | ↑Histamine (ECL), ↑ H+ (Parietal) | Activator |
| Histamine | Released by ACh or Gastrin | ↑ H+ (Parietal) | Activator |
| Prostaglandin | Released by fatty acids (arachidonic acid) | ↑Mucus secretion (Mucous),↓H+ (Parietal) | Inhibitor |
| Somatostatin | Released by luminal acid | ↑Mucus secretion (Mucous), ↓H+ (Parietal), ↓Gastrin (G), ↓ Histamine (ECL), ↓Pepsin (Chief) | Inhibitor |