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Patho unit 2 set 2
Immune Deficiencies
| Question | Answer |
|---|---|
| Bruton agammaglobulinemia | No mature B-cells, Often Fatal |
| IgA deficiency | Selective deficiency of IgA, GI/respiratory infections, not fatal |
| Chronic mucocutaneous candidiasis | Lack of T-cells that attack Candida albicans, not fatal |
| DiGeorge syndrome | lack of mature T-cells, often fatal |
| SCID – Severe combined immune deficiency | no lymphocytes,potentially fatal (‘bubble boy’) |
| Bare lymphocyte | Lack of MHC-I and MHC-II molecules,no Ag presentation, potentially fatal |
| Wiskott-Aldrich | Deficiency of IgM and platelets (thrombocytopenia), not fatal |
| C3 deficiency | Lack of C3 , not fatal |
| CGD- Chronic granulomatous disease | no phagocytes, not fatal |
| HIV – Human immunodeficiency virus | acquired immunodeficiency syndrome (AIDS) |
| HIV effects | Infects Th-cells (CD4), leads to combined B and T-cell immune failure |
| How HIV is transmitted | blood products, IVDU, sex, M-F (placenta/canal/milk) |
| Type of virus HIV is | RNA retrovirus that hijacks T-cells to make viral DNA |
| Unique features of HIV | RNA retrovirus that hijacks T-cells to make viral DNA |