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Ch. 16 Urinalysis

Chapter 16 Urinalysis

QuestionAnswer
Failure of the kidneys to produce urine Anuria
The presence of bilirubin in the urine Bilirubinuria
The passing of a sterile catheter through the urethra and into the bladder to remove urine Bladder catheterization
Secretion and passage of large amounts of urine Diuresis
Difficult or painful urination Dysuria
The condition of having to urinate often Frequency
The presence of glucose in the urine Glycosuria
Blood present in the urine Hematuria
The presence of ketone bodies in the urine Ketonuria
An accumulation of large amounts of ketone bodies in the tissues and body fluids Ketosis
The act of voiding urine Micturition
The functional unit of the kidney that filters waste substances from the blood and dilutes them with water to produce urine Nephron
Excessive (voluntary) urination during the night Nocturia
Inability of an individual to control urination at night during sleep (bedwetting) Nocturnal enuresis
Decreased or scanty output of urine. Less than 400 mL in 24 hours. Oliguria
The unit that describes the acidity or alkalinity of a solution pH
Increased output of urine. Exceeding 2000 mL in 24 hours Polyuria
The presence of protein in the urine Proteinuria
The presence of pus in the urine Pyuria
The concentration at which a substance in the blood that is not normally excreted by the kidneys begins to appear in the urine Renal threshold
The inability to empty the bladder. The urine is being produced normally but is not being voided Retention
The weight of a substance compared with the weight of an equal volume of distilled water Specific gravity (urine)
The clear liquid that remains at the top after a precipitate has settled Supernatant
The passing of a sterile needle through the abdominal wall into the bladder to remove urine Suprapubic aspiration
The immediate need to urinate Urgency
The physical, chemical, and microscopic analyses of urine Urinalysis
The inability to retain urine Urinary incontinence
The function of the urinary system is to regulate the fluid and electrolyte balance of the body and to remove waste products
The urinary system consists of: kidneys, ureters, urinary bladder, and urethra
Are bean-shaped organs approximately 4.5 inches long and 2 to 3 inches wide and are located in the lumbar region of the body kidneys
Urine drains from the kidneys into the urinary bladder through two tubes known as Ureters
Each ureter is approximately: 10 to 12 inches long and 1/2 inch in diameter
Is a hollow, muscular sac that can hold approximately 500 mL of urine Urinary bladder
What is the function of the urinary bladder? to store and expel urine
Is a tube that extends from the urinary bladder to the outside of the body Urethra
Is the external opening of the urethra Urinary meatus
In males, the urethra functions in transporting: Urine and reproductive secretions
In females, the urethra functions in: Urination only
Each kidney contains approximately 1 million smaller units known as Nephrons
Is the functional unit of the kidney. It filters waste substances from the blood and dilutes them with water to produce urine. It also reabsorbes substances like water, glucose, and electrolytes and returns them back to the body Nephron
Urine is composed of: 95% water and 5% organic and inorganic waste products
Organic waste products in urine consist of: Urea, uric acid, ammonia, and creatinine
Is present in the greatest amounts in urine and is derived from the breakdown of proteins Urea
Inorganic waste products in urine include: Chloride, sodium, potassium, calcium, magnesium, phosphate, and sulfate
A normal adult excretes approximately: 750 to 2000 mL of urine per day
Polyuria can be caused by: Excessive intake of fluids or the intake of fluids that contain caffeine, certain drugs such as, diuretics and the pathologic conditions of diabetes mellitus, diabetes insipidus, and renal disease
Oliguria may occur with: Decreased fluid intake, dehydration, profuse perspiration, vomiting, diarrhea, or kidney disease
The advantages of urine testing are: That urine is readily available and obtaining it does not require an invasive procedure or the use of special equipment
List two functions of the urinary system: Regulate fluid and electrolyte balance of the body and remove waste products
What is the function of the urinary bladder? Store and expel urine
What is the function of the ureters? Drains urine from the kidneys into the urinary bladder
How does the function of the urethra differ in the male and female? In males, it transports urine and reproductive secretions and in females it just transports urine
What is the urinary meatus? Is the external opening of the urethra
Most of the urine (95%) is composed of what substance? Water
How much urine does the normal adult excrete each day and what causes the amount to vary? Approximately 750 to 2000 mL a day and varies according to the amount of fluid consumed and the amount lost by other means
What are four conditions that cause polyuria? Excessive intake of fluids, diabetes mellitus, diabetes insipidus, and renal disease
What are four conditions that cause oliguria? Decreased fluid intake, dehydration, profuse perspiration, vomiting, diarrhea, or kidney disease
What type of urine specimen is required for the detection of a UTI? Clean-catch midstream specimen
Why is the first-voided morning specimen often preferred for urine testing? Because it contains the greatest concentration of dissolved substances and a small amount of an abnormal substance that is present would be more easily detected
What is the purpose of performing the clean-catch midstream urine collection procedure? Is to remove microorganisms from the urinary meatus and the distal urethra
What type of test is performed on a first-catch urine specimen? Chlamydia and gonorrhea using a nucleic acid amplification (NAA) test
What is the purpose of a 24-hour urine specimen? Use for the quantitative measurement of specific urinary components
Why should a patient not void directly into a 24-hour urine specimen container that contains a preservative? The preservative could splash onto the patient's skin resulting in a chemical burn
What changes may take place in a urine specimen, if it is allowed to stand at room temperature for more than 1 hour Bacteria gets into specimen & work on urea present in the urine converting it to ammonia. Bacteria multiply rapidly resulting in a cloudy specimen & increase in the nitrite. Cast decompose after several hours. Red & white blood cells present may breakdown
Why does concentrated urine tend to be a darker yellow? Because it contains more dissolved substances
What can cause a freshly voided urine specimen to be cloudy? Maybe the presence of bacteria, pus, blood, fat, yeast, sperm, mucus threads, or fecal contaminants
What is the odor of a urine specimen that has been allowed to stand at room temperature for a long period of time? Has an ammonia odor from the breakdown of urea by bacteria
What is the purpose of testing the specific gravity of urine? Indicates the amount of dissolved substances present in the urine
What are conditions that cause an increase in the specific gravity of urine? Adrenal insufficiency, congestive heart failure, hepatic disease, and diabetes mellitus with glycosuria
What is the normal range for the specific gravity of urine? 1.005 to 1.030
Why does concentrated urine have a higher specific gravity? Because of the increased amount of dissolved substances
What conditions can be evaluated and diagnosed through the chemical examination of urine? Kidney function, UTI, carbohydrate metabolism (diabetes mellitus), and liver function
What is the normal range for the pH of urine? 5 to 7.5
What may cause an increase in the pH of urine? Bacterial infection of the urinary tract
Why does urine become more alkaline if it is not preserved? Urea is converted to ammonia by bacterial action, which causes it to be more alkaline
What may cause glycosuria? Diabetes mellitus is the most common cause
What conditions may cause proteinuria? Stress or strenuous exercise, glomerular filtration problems, renal disease, and bacterial infection of the urinary tract
What may cause ketonuria? Diabetes mellitus, starvation, and a diet composed entirely of fat
How is bilirubin normally eliminated from the body? Transported to the liver by the blood and excreted into the bile, and it eventually leaves the body through the intestines in the feces, giving the stool it's brown color
What conditions may cause bilirubin to appear in the urine? Gallstones, hepatitis, and cirrhosis
What may cause blood to appear in the urine? Result of an injury or cystitis, tumors of the bladder, urethritis, kidney stones, and certain kidney disorders
Why should a nitrite test not be performed on a urine specimen that has been left standing at room temperature? Because a false-positive result may occur from bacterial contamination from the environment
Why should a nitrite test be performed on a first-voided morning specimen? Must be performed with urine that has been in the bladder for at least 4 to 6 hours to ensure that bacteria has converted nitrate to nitrite
What conditions cause leukocyturia? Acute and chronic pyelonephritis, cystitis, and urethritis
What should be done if a urine specimen is unable to be tested within1 hour of voiding? Should be refrigerated immediately and then allowed to return to room temperature before testing
How should urine reagent strips be stored? In a cool, dry area away from direct sunlight with the cap tightly closed to maintain reactivity of the reagent
How does a quality control test ensure the reliability of reagent strip urine testing? By determining whether the reagent strips are reacting properly and confirming that the test is being properly performed and accurately interpreted
What problems may cause a urine strip quality control test to fail to produce expected results? Outdated reagent strips, improper storage of the strips, and an error in testing technique
When should a urine reagent strip quality control test be performed? When each new container of strips is opened for the first time or when a question of reliability arises regarding test strips
What is the purpose of performing a microscopic examination of the urine? Helps to clarify the results of the physical and chemical examination of urine
What is urine sediment? Is the solid material contained in the urine
Why is the first-voided urine specimen recommended for a microscopic examination of the urine? Because it is more concentrated and contains more dissolved substances
What effect does concentrated urine have on red blood cells? Causes red blood cells to become shrunken or crenated
What effect does dilute urine have on red blood cells? Causes them to swell and become rounded which may cause them to hemolyze
What condition may be indicated by an elevated number of white blood cells in the urine sediment? Pyelonephritis, cystitis, urethritis, prostatitis, transplant rejection, tissue injury accompanied by severe inflammation, and inflammation, immune mechanisms, and other host defense mechanisms
What are urinary casts? Cylindric structures formed in the lumen of the tubules that make up the nephron
What is the name of the vaginal infection caused by yeast? Vulvovaginal candidiasis
List three reasons for performing a pregnancy test To initiate early prenatal care. Before certain medications are ordered. Before procedures are performed that may cause injury to a fetus.
What is the name of the hormone that is present in the urine and blood only of a pregnant woman? Human chorionic gonadotropin (HCG)
What is the preferred specimen for a urine pregnancy test? First-voided morning specimen
What may occur if the specific gravity of a urine specimen is less than 1.007? Is considered too dilute for pregnancy testing and may lead to a false-negative test results
What is the purpose of an internal control built into a urine pregnancy test? To evaluate whether certain aspects of the testing procedure are working properly
What conditions (other than a normal pregnancy) can result in a positive urine pregnancy test? Ectopic pregnancy and molar pregnancy
Urine testing in the medical office is often performed on Freshly voided random specimens
A first-voided morning specimen is recommended for Pregnancy testing
A clean-catch midstream specimen is necessary for Identification of the presence of a urinary tract infection (UTI)
The urinary bladder and most of the urethra are normally Free of microorganisms
The distal urethra and the urinary meatus normally Harbor microorganisms
The purpose of a clean-catch midstream collection is: To remove microorganisms from the urinary meatus and the distal urethra
How is a clean-catch midstream specimen accomplished? Thoroughly cleanse the area surrounding the meatus and to void a small amount of urine into the toilet which flushes out microorganisms in the distal urethra. Is collected in a sterile container using medically aseptic techniques.
A first-catch urine specimen can be used to test for The presence of chlamydia and gonorrhea using a nucleic acid amplification (NAA) test
To obtain a first catch urine specimen the patient should: Not urinate for at least 1 hour prior to the collection of the urine specimen. Should not cleanse the genital area before collecting the specimen. Should be instructed to collect only 15 to 30 mL of the initial urine stream in the specimen container.
The first 15 to 30 mL of urine voided by the patient in the first-catch urine specimen contains: The greatest concentration of chlamydia and or gonorrhea bacteria, resulting in the greater likelihood that the NAA test will detect the presence of these pathogens
Collection of more than 30 mL of urine in the first-catch urine specimen results in Dilution of the specimen which may affect the accuracy of the test results
Collecting urine over a 24-hour period provides Greater accuracy and measurement of urinary components
Examples of substances measured in a 24-hour specimen include: Calcium, cortisol, lead, potassium, protein, and urea nitrogen
A 24-hour specimen is often used in the diagnosis of the Cause of kidney stone formation and in the control and prevention of new stone formation. May also be used to perform a creatinine clearance test, which provides information on kidney function.
Is used to store the urine collected over the 24-hour period large wide-mouthed container (3000 mL)
Examples of urine preservatives include: Hydrochloric acid, boric acid, acetic acid, and toluene
What should be attached to the specimen container with a preservative? A hazardous chemical warning label
Certain medications can alter a 24-hour urine specimen and the provider usually requires the patient to discontinue for 1 week before test. These medications include: Thiazides, phosphorus-binding antacids, allopurinol, and vitamin C
Urinalysis consists of a: Physical, chemical, and microscopic examination of urine
If a urine specimen cannot be examined within 1 hour of voiding it should be Preserved at once in the refrigerator in a closed container and later returned to room temperature and mixed before testing
The physical examination of urine includes: A determination of color, appearance, odor, and specific gravity of urine
For an accurate evaluation of the color and appearance the urine specimen must be collected in A clear plastic container
The color of the urine is the result of the presence of a yellow pigment known as Urochrome, produced by the breakdown of hemoglobin
Classifications that can be used to describe the color of urine include: Light yellow, yellow, dark yellow, amber, and dark amber
Abnormal urine color assists in determining additional tests that may be necessary. Abnormal colors may be caused by the presence of Hemoglobin or blood (resulting in a red or reddish color), bile pigments (resulting in a yellow brown or greenish color) and fat deposits or pus (resulting in a milky color)
What urinary tract analgesic causes the urine to change to a orange to red color? Phenazopyridine (Pyridium)
Fresh urine is usually Clear or transparent, but becomes cloudy if left standing out too long
Cloudiness in a freshly voided specimen may be the result of the presence Of bacteria, pus, blood, fat, yeast, sperm, mucus threads, or fecal contaminants
A microscopic examination of the urine sediment is usually performed on all Cloudy specimens to determine the cause of the cloudiness
Classifications used to describe the appearance of urine include: Clear, slightly cloudy, cloudy, and very cloudy
Freshly voided urine normally should have a Slightly aromatic odor
Urine left standing out for a long time develops an Ammonia odor from the breakdown of urea by bacteria in the specimen
The urine odor of a patient with diabetes mellitus may have A fruity odor from the presence of ketone
The urine odor of a patient with a UTI is usually Foul smelling and the odor becomes worse on standing
Certain foods can cause the urine to have a musty smell like Asparagus
Although urine may have many characteristic odors, as a rule the odor of urine is not typically used in The diagnosis of a patient's condition
Indicates the amount of dissolved substances present in the urine providing information on the ability of the kidneys to dilute or concentrate the urine Specific gravity
Specific gravity is decreased in conditions in which the kidneys cannot concentrate the urine such as Chronic renal insufficiency, diabetes insipidus, and malignant hypertension
The specific gravity is increased in patients with Adrenal insufficiency, congestive heart failure, hepatic disease, diabetes mellitus with glycosuria, and conditions that cause dehydration such as fever, vomiting, and diarrhea
The normal specific gravity of urine ranges from 1.005 to 1.030 (but is usually between 1.010 and 1.025)
The specific gravity of distilled water is 1.000
Dilute urine contains fewer dissolved substances and has a Lower specific gravity
Concentrated urine has a increased amount of dissolved substances and has a Higher specific gravity
In the medical office, specific gravity is most commonly measured using a Reagent strip
What percentage of all work-related accidents can be traced to substance abuse 65%
A comprehensive drug testing program includes: The detection of drug use in the workplace, policies to discourage further abuse, and the referral of employees for treatment and rehabilitation
Drug testing may be performed for one or more of the following purposes: Preemployment drug screening testing, for probable cause after unexplained behavior or an incident, and random sample testing of the workforce to detect use of controlled substances by employees on the job
Current urine screening test target the most common drugs of abuse they are: Alcohol, amphetamines, barbiturates, benzodiazepines, cocaine, marijuana, opioids, phencyclidine (PCP) and methadone
To help ensure reliable and valid drug testing results a security system must be followed in the collection and handling of the specimen this is called "Chain of custody"
Chemical examination of urine includes: pH, glucose, protein, ketone, bilirubin, urobilinogen, blood, nitrite, and leukocytes
The pH reading of 7.0 is Neutral
The pH reading less than 7.0 indicates Acidity
The pH reading greater than 7.0 indicates Alkalinity
For an accurate pH reading of the urine the measurement should be performed on Freshly voided urine
The pH of urine can normally range from 5 to 7.5
The pH of a freshly voided specimen of a patient on a normal diet is usually acidic and has a pH reading of 6.0
An abnormally high pH reading on a fresh specimen may indicate a Bacterial infection of the urinary tract
The renal threshold for glucose is typically 160 to 180 mg/dL (100 mL of blood)
What is the most common cause of glycosuria Diabetes mellitus
Some individuals have a low renal threshold and glucose may appear in the urine after the consumption of a large quantity of foods containing sugar. This condition is known as Alimentary glucosuria
A temporary increase in urine protein (proteinuria) may be caused by Stress or strenuous exercise
Some conditions that may cause proteinuria include: Glomerular filtration problems, renal disease, and bacterial infection of the urinary tract
Are normal products of fat metabolism and can be used by muscle tissue as a source of energy Ketones
The three types of ketone bodies are? B-hydroxybutyric acid, acetoacetic acid, and acetone
Conditions that can cause increased fat metabolism resulting in ketonuria include: Uncontrolled diabetes mellitus, starvation, and a diet composed almost entirely of fat
When a red blood cell breaks down, one of the substances released from the breakdown of hemoglobin is a vivid yellow pigment known as Bilirubin
What conditions can cause an increase of bilirubin in the urine? Liver conditions like hepatitis and cirrhosis and gallbladder problems like gallstones
What does urine look like when bilirubin is present? Becomes yellow-brown or greenish and a yellow foam appears when the urine is shaken
Conditions that may increase the level of urobilinogen in the urine include: Excessive hemolysis of red blood cells, infectious hepatitis, cirrhosis, congestive heart failure, and infectious mononucleosis
Is considered an abnormal constituent of urine Blood
The condition in which blood is found in the urine is termed Hematuria
Hematuria may be the result of Injury or disorders such as cystitis, tumors of the bladder, urethritis, kidney stones, and certain kidney disorders
Nitrite in the urine indicates the presents of a Pathogen in the (normally sterile) urinary tract, which results in a UTI
A pathogen possesses the ability to convert nitrate, which normally occurs in urine into Nitrite which is normally absent
The nitrite test must be performed with urine that has been in the bladder for at least 4 to 6 hours
What urine specimen is recommended for a nitrite test? First-voided morning specimen
Examples of specific conditions that cause leukocyturia include: Acute or chronic pyelonephritis, cystitis, and urethritis
The recommended urine specimen for the presence of leukocyturia is A clean-catch midstream collection
Multistix10 SG is a CLIA-waived test that contains 10 reagent pads for testing pH, protein, glucose, ketone, bilirubin, blood, urobilinogen, nitrite, specific gravity, and leukocytes
Indicate whether a substance is present in the urine and also may provide an approximate indication of the amount of the substance present Qualitative test results
The reagent strip test results provide information to assist in diagnosis of the following: Conditions affecting kidney function, UTIs, conditions affecting carbohydrate metabolism (diabetes mellitus), conditions affecting liver function (hepatitis). Test results also provide information on a patient's acid-base balance and urine concentration
Guidelines for testing urine with a reagent strip to ensure accurate test results include: Type of specimen. Type of collection. Urine specimen container. Time intervals. Interpretation and reading of results. Storage of reagent strips.
The container of reagent strips must be stored at a temperature between 59° F and 86° F
A tan-to-brown discoloration or darkening of the reagent pads indicates Deterioration of the reagent strips, in which case the strips should not be used because the test results would be inaccurate
To check the reliability of Multistix reagent strips what should be used Chek-Stix control
Some medical offices perform moderate complexity test which involve the examination of a specimen under the microscope known as Provider-performed microscopy (PPM)
The microscopic examination of urine sediment is a PPM procedure and must be performed by An individual with the proper training and skill qualifications such as a medical office provider
The presence of blood in urine at a normal level is 0 to 3 per high-power field (HPF)
The presence of white blood cells in urine at a normal level is 0 to 5 per high-power field (HPF)
Are large, clear, flat cells with an irregular shape. They contain a small nucleus and come from the urethra, bladder, and vagina. Are normally present in small amounts in the urine. Squamous epithelial cells
Are round and contain a large nucleus. They come from the deeper layers of the urinary tract and their presence in the urine is considered abnormal. Renal epithelial cells
Are pale, colorless, cylinders with rounded edges that vary in size Hyaline cast
Are hyaline cast that contain granules and are described as "coarsely granular" or "finally granular" depending on the size of the granules Granular casts
Are hyaline cast that contain fat droplets Fatty casts
Are light yellow and have serrated edges their name is derived from the fact that they appear to be made of wax Waxy casts
Contain organized structures and are named according to what they contain. (Ex. Red blood cell casts, white blood cell casts, epithelial casts, and bacterial casts) Cellular casts
Abnormal crystals found in the urine include: Leucine, tyrosine, cystine, and cholesterol
Crystals that commonly appear in acid urine include: Amorphous urates, uric acid, and calcium oxalate
Crystals that commonly appear in alkaline urine include: Amorphous phosphate, triple phosphate, calcium phosphate, and ammonium urate crystals
A UTI is usually treated with a Antibiotic
The most common source of infection of a UTI is E. coli
Are normally present in small amounts in the urine. They appear as long, wavy, thread-like structures with pointed ends Mucus threads
Should not normally exist in the urinary tract. The presence of more than a few may indicate either contamination of the specimen during collection or a UTI Bacteria
Are smooth, refractile bodies with an oval shape. A distinguishing feature is small buds that project from the cells involved with reproduction. Yeast
Yeast cells in the urine of female patients are usually a vaginal contaminant caused by the yeast Candida albicans
Candida albicans produce a vaginal infection known as Vulvovaginal candidiasis
Yeast cells may also be present in the urine of patients with Diabetes mellitus
Maybe present in the urine sediment as a contaminant from fecal or vaginal material Parasites
Is a parasite that causes trichomoniasis vaginitis Trichomonas vaginalis
Maybe present in the urine of a man or woman after intercourse. Has round heads and long, slender, hairlike tails Spermatozoa
In the medical office, immunologic tests are often used for pregnancy testing. These tests are performed on a concentrated urine specimen and rely on the presence of a hormone known as Human chorionic gonadotropin (HCG)
Is produced by the developing fertilized egg and small amounts of it is secreted into the urine and blood Human chorionic gonadotropin (HCG)
HCG increases rapidly and can be used to detect pregnancy with a serum pregnancy test as early as 6 days before the first missed menstrual period
The highest plasma levels of HCG occur at approximately 8 weeks after conception
Within 72 hours of delivery HCG Disappears entirely from the plasma
Pregnancy tests are more sensitive during the First trimester
When performed correctly most urine pregnancy tests are 99% accurate with low occurrences of false-positive test results
Early prediction urine pregnancy test may be able to detect pregnancy as early as 2 to 3 days before a first missed menstrual period
Accurate results are much more probable if the urine is tested 1 week after a missed period
Is a non-waived quantitative test used to detect HCG in the serum of the blood Radioimmunoassay (RIA)
A serum pregnancy test can usually detect pregnancy at approximately The 8th day after fertilization, which is 6 days before the first missed menstrual period
The serum pregnancy test is usually used to diagnose abnormalities such as Ectopic pregnancy; to follow the course of early pregnancy with abnormalities of embryonic development are suspected; and to provide an early diagnosis of pregnancy in individuals at high risk, such as patients with diabetes
Possible causes of red blood cells in urine sediment include: Inflammatory disease, acute glomerulonephritis, pyelonephritis, hypertension, renal infarction, trauma, stones, tumor, bleeding diseases, use of anticoagulants
Possible causes of white blood cells in urine sediment include: Pyelonephritis, cystitis, urethritis, prostatitis, transplant rejection, tissue injury accompanied by severe inflammation
Possible causes of squamous epithelial cells in urine sediment include: Vaginal contamination
Possible causes of renal tubular epithelial cells in urine sediment include: Acute tubular necrosis, glomerulonephritis, acute infection, renal toxicity, and viral infection
Possible causes of hyaline casts in urine sediment include: Normal urine, strenuous exercise, acute glomerulonephritis, acute pyelonephritis, malignant hypertension, chronic renal disease
Possible causes of uric acid in urine sediment include: Usually nonpathologic; In large numbers, may indicate gout
Possible causes of calcium oxalate in urine sediment include: Usually nonpathologic; may be associated with stone formation
More than 100,000 bacteria per mL indicates Urinary tract infection
Created by: Diamond87
 

 



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