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GI Meds
| Class | Generic | Brand | BBW | Dosing |
|---|---|---|---|---|
| Antihistamines | Dimenhydrinate | Dramamine | ||
| Antihistamines | Diphenhydramine | Benadryl | ||
| Antihistamines | Meclizine | Dramamine all day less drowsy, Antivert, Bonine | ||
| Antihistamines | Doxylamine | - | ||
| Antihistamines | Hydroxyzine | Vistaril, Atarax | ||
| Antihistamines | Scopolamine | Transderm Scop | ||
| Antihistamines | Trimethobenzamide | Tigan | ||
| Dopamine Receptor Antagonist (Phenothiazines) | Chlorpromazine | Thorazine | increased mortality in elderly patients with dementia-related psychosis | |
| Dopamine Receptor Antagonist (Phenothiazines) | Prochlorperazine | Compazine | increased mortality in elderly patients with dementia-related psychosis | |
| Dopamine Receptor Antagonist (Phenothiazines) | Promethazine | Phenergan, Promethegan | Do not use in children <2 years (risk of respiratory depression). Severe tissue injury with injectable formulation (deep IM is preffered) | |
| Dopamine Receptor Antagonist (Butyrophenones) | Haloperidol | Haldol | - | |
| Dopamine Receptor Antagonist (Butyrophenones) | Droperidol | - | QTc prolongation, need 12 week lead EKG prior to administration followed by 2-3 hours of monitoring | |
| Dopamine Receptor Antagonist (prokinetic and central) | Metoclopramide | Reglan | Tardive dyskinesia | |
| Dopamine Receptor Antagonist | Olanzapine | Zyprexa | Increased mortality in dementia related psychosis | |
| 5-HT3 Antagonist | Granisetron | Sancuso, Sustol | ||
| 5-HT3 Antagonist | Ondansetron | Zofran, Zuplenz film | ||
| 5-HT3 Antagonist | Palonosetron | Aloxi | ||
| 5-HT3 Antagonist | Dolasetron | Anzemet | ||
| NK1 Antagonist | Aprepitant (PO) Fosaprepitant (IV) | Emend | 3A4 inhibitor (decrease dex), 2C9 Inducer (decreased OC) | |
| NK1 Antagonist | Netupitant/Palonosetron (PO) Fosnetupitant/Palonosetron (IV) | Akynzeo | 3A4 inhibitor (decrease dex) | |
| NK1 Antagonist | Rolapitant | Varubi | 2D6 inhibitor (increased chemo agents concentration) | |
| Cannabinoids | Dronabinol | Marinol | ||
| Cannabinoids | Nabilone | Cesamet | ||
| PPI (1a- P-CAB) | Vonoprazan | Voquenza | ||
| H2 Antahistamine | Cimetidine | Tagamet | ||
| H2 Antahistamine | Famotidine | Pepcid | ||
| H2 Antahistamine | Ranitidine | Zantac | ||
| PGE | Misoprostol | Cytotec | ||
| H2 Antahistamine | Nizatidine | Axid | ||
| PPI | Dexlansoprazole | Dexilant | ||
| PPI | Esomeprazole | Nexium | ||
| PPI | Lasnsoprazole | Prevacid | ||
| PPI | Omeprazole | Prilosec | ||
| PPI | Pantoprazole | Protonix | ||
| PPI | Rabeprazole | Aciphex | ||
| Chloride Channel Activator & Guanylate cyclase -C Agonsit | Lubipristone | Amitiza | ||
| Chloride Channel Activator & Guanylate cyclase -C Agonsit | Linaclotide | Linzess | ||
| Chloride Channel Activator & Guanylate cyclase -C Agonsit | Plecanatide | Trulance | ||
| MOR Antagonists for OIC/Post op ileus | Alvimopan | Entereg | ||
| MOR Antagonists for OIC/Post op ileus | Methylnaltrexone | Relistor | ||
| MOR Antagonists for OIC/Post op ileus | Naloxegol | Movantik | ||
| MOR Antagonists for OIC/Post op ileus | Naldemedine | Symproic | ||
| Opioid Agonists (antisecratory) | Loperamide | Diamode/Imodium | ||
| Opioid Agonists (Antimotility) | Diphenoxylate and atropine | Lomotil | Adult: 5mg-0.050mg QID x 10days (MAX 20mg-0.2mg) | |
| Opioid Agonists | Difenoxin and atropine | motofen | ||
| Antisecretory | Octreotide | Sandostatin | ||
| Bile salt-binding Resins (Bile acid sequestrants) | Cholestyramine | Prevalite, Questran | ||
| Bile salt-binding Resins (Bile acid sequestrants) | Colestipol | Colestid | ||
| Bile salt-binding Resins (Bile acid sequestrants) | Colesevelam | Welchol | ||
| Serotonin-3 receptor Antagonists | Alosetron | Lotronex | ||
| Sodium/Hydrogen Exchanger 3 Inhibitor | Tenapanor | Ibsrela | ||
| 5-Aminosalicylates (5-ASA) (Azo compounds) | Balsalazide | Colazal | ||
| 5-Aminosalicylates (5-ASA) (Azo compounds) | olsalazine | Dipentum | ||
| 5-Aminosalicylates (5-ASA) (Azo compounds) | Sulfasalazine | Azulfidine | ||
| 5-Aminosalicylates (5-ASA) (Mesalamine compound) | Mesalamine | Pentasa, Asacol, Rowasa, Canasa | ||
| TNF-alpha inhibitors | Infliximab | Remicade | ||
| TNF-alpha inhibitors | Adalimumab | Humira | ||
| TNF-alpha inhibitors | Golimumab | Simponi | ||
| TNF-alpha inhibitors | Certolizumab | Cimzia | ||
| Biologics: Integrin Inhibitors | Vedolizumab | Entyvio | ||
| Biologics: IL inhibitors | Ustekinumab | Stelara | ||
| Janus Kinase Inhibitors | Tofacitinib | Xeljanz | ||
| Janus Kinase Inhibitors | Upadacitinib | Rinvoq | ||
| S1P Receptor Modulators | Etrasimod | Velsipity | ||
| S1P Receptor Modulators | Ozanimod | Zeposia | ||
| Immunomodulators: Calcineurin inhibitors | Cyclosporine | (peptide) | ||
| Immunomodulators: Calcineurin inhibitors | Tacrolimus | (macrolide) | ||
| Bulk Forming Laxatives | Psyllium | metamucil | ||
| Bulk Forming Laxatives | Methylcellulose | Citrucel | ||
| Bulk Forming Laxatives | Polycarbophil | FiberCon | ||
| Emollients (stool Softeners) | Docusate | Colace | 100mg PO BID | |
| Emollients (Lubricants) | Mineral oil | Milkinol | ||
| Osmotic Laxatives | PEG | Miralax, GoLytely | 17g PO daily | |
| Osmotic Laxatives | Lactitol | Pizensy | ||
| Osmotic Laxatives | lactulose | Constulose | ||
| Osmotic Laxatives (saline laxatives) | Magnesium hydroxide | milk of magnesia (MOM) | ||
| Stimulant Laxatives | Bisacodyl | Dulcolax | 5-15mg PO daily, 10mg PR | |
| Stimulant Laxatives | Senna | Senok, Ex-Lax | 17.2mg PO daily | |
| Opioid Receptor Antagonists | MATCH: Naloxegol | Movantik | 25mg PO daily | |
| Opioid Receptor Antagonists | MATCH: Naldemedine | Symproic | 0.2mg PO daily | |
| Opioid Receptor Antagonists | MATCH: Methylnaltrexone | Relistor | ||
| Antimotility Agents and Predominant IBS | Loperamide (OTC) | Imodium | Adults: 4mg --> 2mg after each stool x 48hrs (MAX 16mg/day) Child: half the adult dose (MAX 6mg or 4mg) | |
| Predominant IBS-C* | MATCH: Linaclotide* | Linzess* | 290mcg PO daily | |
| Predominant IBS-C* | MATCH: Plecanatide* | Trulance* | 3mg PO daily | |
| Predominant IBS-C | MATCH: Tenapanor | Ibsrela | 50mg PO BID | |
| Predominant IBS-C | MATCH: Lubiprostone | Amitiza | 8mcg PO BID | |
| Predominant IBS-D (Opioid agonist/anti motility) | Eluxadoline | Viberzi | 100mg PO BID | |
| Predominant IBS-D | MATCH: Rifaximin | Xifaxan | 550mg PO TID x 2weeks | |
| Predominant IBS-D | MATCH: Alostetron | Lotronex | ||
| Antisposmodic | Dicyclomine | Bentyl | 20mg PO QID x 7days --> 40mg QID | |
| Antisposmodic | Hyoscyamine | Levsin | 0.125-0.25mg PO q4h PRN (MAX 1.5mg/day) | |
| Osmotic Laxatives (saline laxatives) | Sodium Phosphate | Fleet enema | ||
| Emollient Laxative | Castor Oil | - | ||
| Immunosuppressive | Azathioprine | Imuran | ||
| Immunosuppressive | Mercaptopurine | purinethol | ||
| Immunosuppressive | Cyclosporine | sandimmune | ||
| Immunosuppressive | Methotrexate | trexall | ||
| Mesalamine | Pentasa | ER | ||
| Mesalamine | Apriso | ER | ||
| Mesalamine | Asacol | EC | ||
| Mesalamine | Asacol HD | EC | ||
| Mesalamine | Delzicol | DR tablet | ||
| Mesalamine | Lialda | DR capsule | ||
| Mesalamine | Canasa | Supp | ||
| Mesalamine | Rowasa | Enema | ||
| Corticosteroid | Prednisone | 5mg PO | ||
| Corticosteroid | Prednislonone | 5mg PO | ||
| Corticosteroid | Methylprednisolone | 4mg PO | ||
| Corticosteroid | Hydrocortisone | 20mg PO | ||
| Corticosteroid | Dexamethasone | 0.75mg PO | ||
| Biologics: IL-23 inhibitors | Guselkumab | Tremfya | ||
| Biologics: IL-23 inhibitors | Risankizumab | Skyrizi | ||
| Biologics: IL-23 inhibitors | Mirikizumab | Omvoh |
Created by:
Danielle9685