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GI Disorders

ADRs

DrugEndocrine/metabolicCNS AEsGI AEsCardio/BloodRenal
Drug Endocrine/metabolic CNS AEs GI AEs Cardio/Blood Renal
Cimetidine ↓ libido, impotence, gynecomastia, galactorrhea, breast soreness hallucinations (elderly)
Famotidine ↓ libido, impotence, gynecomastia, galactorrhea, breast soreness hallucinations (elderly)
Nizatidine ↓ libido, impotence, gynecomastia, galactorrhea, breast soreness hallucinations (elderly)
Ranitidine ↓ libido, impotence, gynecomastia, galactorrhea, breast soreness hallucinations (elderly)
Omeprazole B12 deficiency; ↓ mineral absorption; ↑ fracture risk hypergastrinemia with chronic use
Esomeprazole B12 deficiency; ↓ mineral absorption; ↑ fracture risk hypergastrinemia with chronic use
Lansoprazole B12 deficiency; ↓ mineral absorption; ↑ fracture risk hypergastrinemia with chronic use
Dexlansoprazole B12 deficiency; ↓ mineral absorption; ↑ fracture risk hypergastrinemia with chronic use
Pantoprazole B12 deficiency; ↓ mineral absorption; ↑ fracture risk hypergastrinemia with chronic use
Rabeprazole B12 deficiency; ↓ mineral absorption; ↑ fracture risk hypergastrinemia with chronic use
Vonoprazan ↑ fracture risk (high dose or >1 yr) hypergastrinemia with chronic use Acute tubulointerstitial nephritis
Calcium carbonate Hypercalcemia; alkalosis Constipation (dose‑related)
Sodium bicarbonate Hypernatremia; alkalosis Gas/abdominal distention, nausea, vomiting
Aluminum hydroxide Hypophosphatemia Constipation
Magnesium hydroxide Hypermagnesemia Diarrhea (dose‑related)
Bismuth subsalicylate Constipation ↑ bleeding risk with anticoagulants
Sucralfate Constipation
Prochlorperazine Neuroleptic malignant syndrome; extrapyramidal reactions: tardive dyskinesia, acute dystonia, drug-induced parkinsonism, akathisia Constipation, dry mouth Prolonged QTc, tachycardia, orthostatic hypotension urinary retention
Chlorpromazine Neuroleptic malignant syndrome; extrapyramidal reactions: tardive dyskinesia, acute dystonia, drug-induced parkinsonism, akathisia Constipation, dry mouth Prolonged QTc, tachycardia, orthostatic hypotension urinary retention
Promethazine Neuroleptic malignant syndrome; extrapyramidal reactions: tardive dyskinesia, acute dystonia, drug-induced parkinsonism, akathisia Constipation, dry mouth Prolonged QTc, tachycardia, orthostatic hypotension urinary retention
Droperidol Neuroleptic malignant syndrome; extrapyramidal reactions: Tardive dyskinesia; dizziness, drowsiness Constipation, dry mouth Prolonged QTc interval, tachycardia urinary retention
Haloperidol Neuroleptic malignant syndrome; extrapyramidal reactions: Tardive dyskinesia; dizziness, drowsiness Constipation, dry mouth Prolonged QTc interval, tachycardia urinary retention
Olanzapine Weight gain (class effect, note for antiemetic use often short-term) Sedation Orthostatic hypotension, ↑QTc; NMS (rare)
Ondansetron asthenia (weakness, fatigue), headache Constipation QTc prolongation: dose dependent, higher risk with IV
Granisetron asthenia (weakness, fatigue), headache Constipation QTc prolongation: dose dependent, higher risk with IV
Palonosetron asthenia (weakness, fatigue), headache Constipation QTc prolongation: dose dependent, higher risk with IV
Dolasetron asthenia (weakness, fatigue), headache Constipation QTc prolongation: dose dependent, higher risk with IV
Aprepitant Dizziness, fatigue, weakness Constipation, hiccups
Fosaprepitant Dizziness, fatigue, weakness Constipation, hiccups
Netupitant Dizziness, fatigue, weakness Constipation, hiccups
Fosnetupitant Dizziness, fatigue, weakness Constipation, hiccups
Rolapitant Dizziness, fatigue, weakness Constipation, hiccups
Dronabinol Somnolence, euphoria Cannabinoid-induced hyperemesis syndrome (CHS); increased appetite Orthostatic hypotension
Nabilone Cannabinoid-induced hyperemesis syndrome (CHS); increased appetite Orthostatic hypotension
Diphenhydramine Drowsiness, confusion, mydriasis, blurred vision, dizziness, tremors, increased intraocular pressure urinary retention, dry mouth, constipation QTc prolongation
Dimenhydrinate Drowsiness, confusion, mydriasis, blurred vision, dizziness, tremors, increased intraocular pressure urinary retention, dry mouth, constipation
Meclizine Drowsiness, confusion, mydriasis, blurred vision, dizziness, tremors, increased intraocular pressure urinary retention, dry mouth, constipation
Hydroxyzine Drowsiness, confusion, mydriasis, blurred vision, dizziness, tremors, increased intraocular pressure urinary retention, dry mouth, constipation QTc prolongation
Doxylamine Drowsiness, confusion, mydriasis, blurred vision, dizziness, tremors, increased intraocular pressure urinary retention, dry mouth, constipation
Scopolamine Drowsiness, confusion, mydriasis, blurred vision, dizziness, tremors, increased intraocular pressure urinary retention, dry mouth, constipation
Metoclopramide Hyperprolactinemia (galactorrhea, gynecomastia) EPS, CNS depression Diarrhea QT prolongation
Pyridoxine (Vitamin B6) High doses over prolonged periods may cause peripheral neuropathy Weakness, lethargy (with high doses)
Ginger Mild GI discomfort, belching Potential anticoagulant and hypotensive effects
Misoprostol abortifacient
Metronidazole Disulfiram-like effect abdominal distress, metallic taste
Created by: CaristW
 

 



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