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resp meds
| Question | Answer |
|---|---|
| Corticosteroid (nasal spray) meds | Budesonide (Rhinocort) Fluticasone (Flonase) Mometasone (Nasonex) Triamcinolone (Nasocort) |
| Corticosteroid action, side effects, care | Decrease inflammation, inhibits leukotrienes & interleukins, promote mucociliary action Used in allergic rhinitis, sinusitis Side effects: nasal irritation, mucosal drying, nosebleeds Teach: daily adherence, takes days to weeks for max effect |
| Mast cell stabilizer (nasal, neb) | Cromolyn (NasalCrom) Action Stabilize mast cells thereby decrease inflammation and bronchoconstriction Used in allergic rhinitis |
| Mast cell stabilizer (nasal, neb) considerations | Use caution with renal and hepatic impairment Side effects: HA, nasal irritation, sneezing, throat irritation, unpleasant taste, epistaxis Use bronchodilators 30 mins before cromolyn |
| LEUKOTRIENE RECEPTOR ANTAGONIST | Montelukast (Singulair) Action Leukotriene released in response to allergen which cause inflammation, bronchoconstriction, & mucous production, this drug blocks this action Used in allergic rhinitis, asthma, COPD |
| LEUKOTRIENE RECEPTOR ANTAGONIST considerations | May take 1 wk before therapeutic Side effect: HA, possible dizziness Monitor liver functions Not for acute asthma attacks |
| ANTIHISTAMINES | 1st Generation Diphenhydramine (Benadryl) Hydroxyzine (Vistaril) Chlorpheniramine 2nd Generation Loratadine (Claritin) Cetirizine (Zyrtec) Fexofenadine (Allegra) Azelastine (Astelin) nasal spray |
| ANTIHISTAMINES action | Block or inhibit histamine at receptors but not production Bronchial smooth muscle relaxation, decreased secretions, reduce itching Used in many disorders (allergic rhinitis, allergic reactions, COPD, asthma) |
| ANTIHISTAMINES considerations | Side effects: CNS depression (drowsiness) or stimulation (anxiety/paradoxical excitement) in 1st generation, anticholinergic effects Oral admin onset 15-60 mins Avoid other CNS depressants Adverse effects: Seizures, dysrhythmias, allergy skin te |
| Decongestants (nasal or oral) | Pseudoephedrine (Sudafed) Phenylephrine (Neo-Synephrine) Oxymetazoline (Afrin) |
| Decongestants (nasal or oral) action | Shrink swollen nasal mucous membranes, sympathomimetics cause vasoconstriction = dec. blood flow = dec. swelling Used in allergic rhinitis, pharyngitis, nasal congestion |
| Decongestants (nasal or oral) considerations | Contraindicated in HTN & CAD Side effects: nasal irritation/dryness, rebound congestion, nervousness, tremors, insomnia, tachycardia, hypertension Nasal for 3 days then switch to oral Avoid caffeine and increase fluid intake |
| Expectorants | Guaifenesin (Robitussin, Mucinex) Action Reduces viscosity of secretions Used in upper resp disorders, cough, asthma, pneumonia, COPD, CF |
| Expectorants considerations | Caution in elderly and respiratory insufficiency Side effects: GI upset, dizziness Increase fluid intake Must cough effectively to work |
| Antitussives (oral tab/liquid) | Benzonatate (Tessalon) Dextromethorphan (Robitussin DM) Guaifenesin w/ Codeine (opioid) Action Suppress cough reflex through CNS suppression (opiod) or without (non-opiod) |
| Antitussives considerations | Opioid: respiratory depression, addiction, contraindicated in liver or renal disease, seizures Nonopioid: Dextromethorphan contraindicated in asthma & emphysema Side effects: dizziness, drowsiness, dry mouth, dysuria |
| MUCOLYTICS | Acetylcysteine (Mucomyst) Action Liquefy respiratory secretions, treat acetaminophen overdose Nursing Considerations Not commonly used Max effect in 5-10 mins Side effect: bronchospasm, oral irritation, HA Foul smell |
| BRONCHODILATORS | Albuterol (Proventil, Ventolin) short acting Levalbuterol (Xopenex) short acting Salmeterol (Serevent) long acting |
| BRONCHODILATORS action | Stimulate beta2 adrenergic receptors causing bronchodilation Used in asthma, COPD |
| BRONCHODILATOR considerations | Side Effects: tachycardia, nausea, anxiety, tremors, insomnia, restlessness, anorexia Watch for hypokalemia & hyperglycemia Administer properly & teach patient Bronchodilator before corticosteroid Rinse mouth out after admin |
| Anticholinergics | Ipratropium (Atrovent) short acting Tiotropium (Spiriva) long acting Action Blocks action of acetylcholine in bronchial smooth muscles |
| Anticholinergics considerations | Approved for COPD, severe asthma attacks Used cautiously in pts with glaucoma or prostate enlargement Side effects: Dry oral membranes, cough, urinary retention, temporary blurred vision with eye contact |
| METHYLXANTHINES | Aminophylline Theophylline Action Inhibit phosphodiesterase = inc cAMP = bronchodilation Used in chronic conditions: COPD, asthma |
| METHYLXANTHINES considerations | Watch for toxicity: restlessness, insomnia, irritable, tremors, N/V, seizures High incidence of drug interaction and side effects Side effects: nausea, headache, insomnia, GI distress, tachycardia, dysrhythmias, seizures Avoid caffeine |
| SYSTEMIC CORTICOSTEROIDS (ORAL, IM, IV) | Hydrocortisone (Solu-Cortef) Methylprednisolone (Solu-Medrol) Prednisone Action Steroid hormone that has anti-inflammatory and immunosuppressive activity Used in asthma, COPD, pneumonia |
| SYSTEMIC CORTICOSTEROIDS considerations | Give with food to minimize GI side effects Glucose monitoring Side effects: euphoria, headache, psychosis, insomnia, edema, delayed wound healing, osteoporosis, bone fractures, hyperglycemia |
| PNEUMONIA VACCINE who should get it | Age ≥65 Age 2-64 with chronic health problems or dec immunity Age 19-64 who smoke or have asthma |
| PNEUMONIA VACCINE effects | Prevnar13, Pneumovax23 (IM) Side effects: pain, redness, and swelling at injection site, mild fever, fatigue, headache, chills, or muscle pain |
| FLU VACCINE | Trivalent or Quadrivalent inactivated influenza vaccine (IM) Injection, approved for >6months of age Do NOT give: Previous serious allergy or reaction to flu vaccine Allergy to chicken or egg products Side effects: site reaction |
| Live attenuated influenza vaccine (nasal spray) | Nasal spray Approved for healthy people ages 2-49 Side effects: runny nose, congestion |
| INFLUENZA MEDICATIONS | Antivirals -vir Oseltamivir (Tamiflu) Zanamivir (Relenza) Baloxavir marboxil (Xofluza) |
| INFLUENZA considerations | Watch liver & kidney function Increase fluid intake Side effect: dry mouth, dizziness, drowsiness, mood/mental changes Do not give Xofluza with dairy or calcium |
| ANTIBIOTICS | Penicillins (beta-lactams) -cillin Amoxicillin (Amoxil) Amoxicillin/clavulanate (Augmentin) Penicillin G Penicillin V Pipercillin/tazobactam (Zosyn) |
| ANTIBIOTICS considerations | Assess allergies Thick IM preparation Decreased efficacy of birth control pills Take on empty stomach Side/adverse effect: GI upset, diarrhea, hypo/hyperkalemia, blood dyscrasias |
| ANTIBIOTICS Macrolides | Azithromycin (Zithromax) Clarithromycin (Biaxin) Clindamycin (Cleocin |
| ANTIBIOTICS Macrolides considerations | Take on empty stomach Watch liver dysfunction & renal dysfunction Increase protein for therapeutic efficacy Watch for ototoxicity: dizzy, vertigo, tinnitus |
| ANTIBIOTICS Fluoroquinolones | Moxifloxacin (Avelox) Levofloxacin (Levaquin) Ciprofloxacin (Cipro) |
| ANTIBIOTICS Fluoroquinolones considerations | Give 2 hours from antacids, iron, and zinc, or sucralfate Increase protein, Change positions slow : HA, lethargy, fatigue, restlessness, elevated liver enzymes, photosensitivity Teach: protection from sun and reporting unusual joint or muscle pain |
| ANTIBIOTICS Cephalosporins | Ceftriaxone (Rocephin) Cefazolin (Ancef) Cefuroxime (Ceftin) Cephalexin (Keflex) |
| ANTIBIOTICS Cephalosporins considerations | Cross sensitivity to PCNs Monitor renal function Give 2 hours from iron Deep IM May take with food Watch inc. PT/INR Inc. fluids and protein Avoid alcohol |
| ANTIBIOTICS Carbapenems | Imipenem/cilastatin (Primaxin) Meropenem (Merrem) Ertapenem (Invanz) |
| ANTIBIOTICS Carbapenems considerations | Watch for seizures Monitor renal, hepatic, neuro- toxicities Deep IM |
| ANTIBIOTICS Aminoglycosides | Gentamycin Neomycin Nephro-, Neuro-, Ototoxicities Monitor peak and trough May be taken with food if GI upset treat severe aerobic Gram-negative bacterial infections, such as sepsis and endocarditis, by inhibiting bacterial protein synthesis |
| Glycopeptide | Vancomycin treat infections in many different parts of the body (bone infections, infective endocarditis, lower respiratory tract infection Nephrotoxic and Ototoxic Monitor peak and trough IV: risk for phlebitis, central line preferred Sid |
| TUBERCULOSIS MEDICATIONS | Antituberculins Rifampin Isoniazid (INH) |
| TUBERCULOSIS MEDICATIONS considerations | Monitor liver function Hepato, nephro, ototoxicity NO alcohol: inc risk for hepatitis Encourage B vitamins Must take full course Rifampin: discolor urine, tears, saliva, stains clothing INH: take 1 hr before meals |