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Skin
Chapter 5 - A & P Lecture
| Question | Answer |
|---|---|
| what is the epidermis? | superficial layer of stratified squamous epithelial tissue that protects and reduces water loss |
| what is the dermis? | deep layer of connective tissue that aids in structural strength |
| what is the subcutaneous tissue? | loose connective tissue that connects skin to underlying structures (not part of skin) |
| does the epidermis have blood vessels? | no it's avascular and nourished by diffusion from capillaries of the papillary layer of the dermis |
| what is the epidermis composed of? | epithelial cells arranged into layer or strata |
| how are the epidermis and dermis separated? | basement membrane |
| list the 4 epidermal cells? | keratinocytes, melanocytes, langerhans cells, merkel |
| what are keratinocytes? | most abundant cell in the epidermis that produces keratin for strength |
| what are melanocytes? | produces melanin that is transferred to keratinocytes and contributes to skin color |
| are melanocyttes dependent? | no, same number in all people |
| what are langerhans cells? | part of the immune system |
| what are merkel cells? | will detect light touch and superficial pressure |
| how does keratinization affect epidermal cells? | as cells move upward they fill with keratin, die, and serve as a layer that resist abrasion (permeability layer) |
| list the epidermal strata from bottom to top? | stratum basale, spinosum, granulosum, lucidum, corneum |
| what are the characteristics of the stratum basale? | deepest portion of epidermis and single layer of cuboidal/columnar cells |
| does the stratum basale have high or low mitotic activity? | high mitotic activity, keratinocyte stem cells undergo mitosis about every 19 days |
| what holds keratinocytes together? | desmosomes |
| how many day does it take to move the stratum basale to the surface and be sloughed off? | 40 to 56 days |
| what are the characteristics of stratum spinosum? | 8 to 10 layers of many-sided cells that flatten as they are pushed upward |
| what does the stratum spinosum contain? | new desmosomes, lipid-filled lamellar bodies, and additional keratin fibers |
| what are the charcteristics of stratum granulosum? | 2 to 5 layers of flattened, diamond-shaped cells |
| what does the stratum granulosum contain? | grules of keratohyalin in the cytoplasm |
| what do lamellar bodies do in the stratum granulosum? | move to the plasma membrane and release their lipid contents into the extracellular space |
| what takes place in the superficial layers of the stratum granulosum? | nucleus and other organelles degenerate and cells dies (keratin fibers & keratohyalin granules do not degenerate) |
| what are characteristics of stratum lucidum? | thin, clear zone of dead keratinocytes with indistinct boundaries |
| where is stratum lucidum found? | palms & soles |
| what are characteristics of stratum corneum? | most superficial, consists of 25 or more layer fo dead overlapping squamous cells joined by desmosomes called cornified cells |
| how many layers of epithelial strata does thick skin have? | all 5 |
| where is thick skin found? | areas subject to pressure/friction ex: palms, fingertips, soles |
| how many layer of epithelial strata does think skin have? | 4(no stratum lucidum) |
| what are some characteristics of thin skin? | more flexible, covers rest of body, hair grows |
| what is a callus? | an increase in number of layers in stratum corneum |
| what is a corn | a callus on a bony prominence |
| what 3 factors is skin color determined by? | pigments, blood cirulating, thickness of stratum corneum |
| what is melanin? | group of chemicals derived from amino acid tyrosine that is colored brown to black (may be yellowish or reddish) and protects against UV light |
| what cause albinism? | deficiency or absence of pigment determined by genes, hormones, exposure to light |
| what is carotene? | yellow pigment form vegetables in the stratum corneum, adipose cells of dermis, and subcutaneous tissue |
| describe the melanin transfer to keratinocytes? | 1) melanocytes produce melanin 2) melanin is packed in melanosomes 3) melanosomes move into cell processes of melanocytes 4) keratinocytes phagocytize tops of melanocyte cell processes 5) keratinocytes acquire melanosomes |
| what a racial variations in skin color due to? | types/# of melanin, size/#/distribution of melanosomes, hormones (estrongen/MSH) during pregnancy |
| what is cyanosis? | blue color caused by decrease in blood oxygen content |
| what is erythema? | red color cause by increased blood flow |
| does thickness impact color? | yes, the thickness of stratum corneum impacts color |
| what is the most common type of cancer? | skin cancer which is the result from damage from UV radiation that damages the DNA in epidermas |
| how does melanin affect likelihood of developing skin cancer? | fair skin people are at greater risk than dark skinned people |
| what are the 3 types of skin cancer? | basal cell carcinoma, squamous cell carcinoma, melanoma |
| what are the characteristics of basal cell carcinoma? | most common, cells of stratuma, varried appearance, cured by removal/destruction |
| what are the characteristics of squamous cell carcinoma? | cells of stratum spinosum, varied appearance, may bleed, cured by removal/destruction |
| what is the most deadly type of skin cancer? | melanoma |
| what is the ABCDE rule? | A(asymmetry), B(border), C(color not uniform), D(diameter greater than 6mm), E(evolving or changing) |
| characteristics of the dermis? | gives structural strength, connective tissue with fibers (collagen, elastic, reticular), fibroblasts, macrophages, and adipocytes |
| what does the dermis contain? | nerves, blood vessels, hair follicles, smooth muscles, glands, lymphatic vessels |
| what are the sensory functions of the dermis? | pain, itch, tickle, temp., touch, pressure, two point discrimination |
| what are the 2 layers of the dermis? | papillary & reticular |
| what is the paillary layer? | superficial , areolar with lots of elastic fibers, dermal papillae, capillary bed, free nerve ending sensing pain |
| what is the reticular layer? | deep, dense irregular of collagen & elastic fibers |
| what does the reticular layer contain? | some adipose tissue, hair follicles, nerves, oil glands, ducts of sweat glands, heat sensor |
| what are clevage (tension) lines? | elastic and collagen fibers oriented in some directions more than others |
| why are clevage lines important in surgery? | if incision parallel to lines there is faster healing and less scar tissue |
| what are stretch marks? | where skin is overstretched |