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Oncology BDK

Colon Cancer

Pharmacologic CategoryGeneric NameMOACommon IndicationsKey Side EffectsClinical PearlsDDI Contraindications
Pharmacologic Category Generic Name MOA Common Indications Key Side Effects Clinical Pearls DDI Contraindications
Antimetabolite (cell cycle S-phase specific) Fluorouracil (5-FU) (Adrucil) Inhibits thymidylate synthase CRC Diarrhea, mucositis, HFS, myelosuppression (BBW) early onset of severe toxicities if patient has DPD deficiency
Antimetabolite (cell cycle S-phase specific) Capecitabine Inhibits thymidylate synthase CRC HFS
DNA alkylating/crosslinking agents (cell cycle phase non-specific) Oxaliplatin intrastrand DNA crosslinking CRC peripheral neuropathy, temporary cold-induced neuropathy, cumulative/permanent sensory neuropathy
Topoisomerase poison (Cell cycle S-phase specific) Irinotecan Topo-I inhibitor mCRC dose-limiting late onset diarrhea, neutropenia treat with low dose loperamide until 12 hrs diarrhea free
Checkpoint inhibitor (immunotherapy) Nivolumab PD-1 inhibitor dMMR/MSI-H CRC w/unresectable mets
Checkpoint inhibitor (immunotherapy) Ipilimumab CTLA-4 inhibitor dMMR/MSI-H CRC w/unresectable mets
Checkpoint inhibitor (immunotherapy) Pembrolizumab PD-1 inhibitor dMMR/MSI-H CRC w/unresectable mets immune-mediated infections: pneumonitis, colitis, hepatitis, endocrinopathies, nephritism skin disorders
Checkpoint inhibitor (immunotherapy) Dostarlimab PD-1 inhibitor dMMR/MSI-H CRC w/unresectable mets Autoimmune disease
Tyrosine kinase inhibitor Cetuximab Anti-EGFR mAb RAS WT left-sided mCRC acneiform rash associated with drug response
Tyrosine kinase inhibitor Panitumumab Anti-EGFR mAb RAS WT left-sided mCRC acneiform rash associated with drug response
Angiogenesis inhibitor Bevacizumab Anti-VEGF mAb mCRC HTN, bleeding, VTE, proteinuria, wound dehiscence
Tyrosine kinase inhibitor Trastuzumab Anti-HER2 mAb HER2+ mCRC LVEF decrease
Tyrosine kinase inhibitor Pertuzumab Anti-HER2 mAb HER2+ mCRC acne-like rash, LVEF decrease
Tyrosine kinase inhibitor Lapatinib HER2/EGFR HER2+ mCRC HFS, acne-like rash
Tyrosine kinase inhibitor Tucatinib HER2 HER2+ mCRC HFS, acne-like rash
Growth factor receptor antagonist Fam-trastuzumab deruxtecan HER2 ADC HER2+ mCRC ILD, LVEF decrease, alopecia
Created by: CaristW
 

 



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