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CNS 3

Pharmacologic CategoryGenericBrandCommon IndicationsEK
Antimanic agent lithium (PO) Lithobid Bipolar disorder Key Side Effects: tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia, GI upset US Boxed Warnings: ability to promptly monitor levels is necessary/ Narrow therapeutic index drug/ Avoid in pregnancy
Antimigraine sumatriptan (PO,Intranasal,SQ) Imitrex Migraine Key Side Effects: fatigue, somnolence, dizziness, chest tightness, paresthesias Other Notes: CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
Antimigraine rizatriptan (PO) Maxalt Migraine Key Side Effects: fatigue, somnolence, dizziness, chest tightness, paresthesias Other Notes: CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
First-Generation antipsychotic haloperidol (PO,IV,IM) Haldol Schizophrenia Key Side Effects: sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Second-Generation antipsychotic clozapine (PO) Clozaril Treatment-resistant schizophrenia SE: Sedation, constipation, orthostasis, sialorrhea, weight gain/hyperglycemia, neutropenia. BBW: Severe neutropenia, seizures, myocarditis/cardiomyopathy, syncope, ↑ death in elderly with dementia psychosis.
Second-Generation antipsychotic aripiprazole (PO,IM) PO/IM: Abilify IM: Aristada Schizophrenia, biopolar disorder, MDD SE: Akathisia, restlessness, sedation, EPS, constipation, orthostasis, weight gain. BBW: ↑ suicidal thoughts/behavior in young patients; ↑ death in elderly with dementia psychosis.
Second-Generation antipsychotic quetiapine (PO) Seroquel, Seroquel XR Schizophrenia, biopolar disorder, MDD SE: Sedation, EPS, constipation, orthostasis, weight gain. BBW: ↑ suicidal thoughts/behavior in young patients; ↑ death in elderly with dementia psychosis.
Second-Generation antipsychotic lurasidone (PO) Latuda Schizophrenia, biopolar disorder, MDD SE: Sedation, EPS, constipation, orthostasis, weight gain. BBW: ↑ suicidal thoughts/behavior in young patients; ↑ death in elderly with dementia psychosis. Note: CI with strong CYP3A4 inhibitors/inducers.
Second-Generation antipsychotic olanzapine (PO,IM) Zyprexa Schizophrenia, biopolar disorder, MDD Key Side Effects: sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Second-Generation antipsychotic risperidone (PO,IM) PO: Risperdal IM: Risperdal Consta Schizophrenia Key Side Effects: sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Created by: jcresend
 

 



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