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Endocrine I
| CATEGORY | GENERIC NAME | BRAND NAME | INDICATOR | SIDE EFFECTS | US WARNINGS | OTHER NOTES |
|---|---|---|---|---|---|---|
| Biguanide | Metformin (PO) | Fortamet, Glumetza, Riomet | Type 2 DM, PCOS | Diarrhea, nausea, vomiting, Vitamin B12 deficiency | Lactic acidosis | Cl with eGFR <30 |
| Dipeptidyl Peptidase (DPP-4) Inhibitor | Sitagliptin (PO) | Januvia, Zituvio | Type 2 DM | Nasopharyngitis | ||
| Sodium-Glucose Contransporter Inhibitor 2 (SGLT2 Inhibitor) | Empagliflozin (PO) | Jardiance | Type 2 DM, HF, CKD | Genital mycotic infections, UTI | ||
| Sodium-Glucose Contransporter Inhibitor 2 (SGLT2 Inhibitor) | Dapagliflozin (PO) | Farxiga | Type 2 DM, HF, CKD | Genital mycotic infections, UTI | ||
| Sulfonylurea | Glimepiride (PO) | Amaryl | Type 2 DM | Hypoglycemia, weight gain | ||
| Sulfonylurea | Glipizide (PO) | Glucotrol, Glucotrol XL | Type 2 DM | Hypoglycemia, weight gain | ||
| Thiazolidinedione (TZD) | Pioglitazone (PO) | Actos | Type 2 DM | Peripheral, edema, weight gain, upper respiratory tract infection; increased risk of fractures and bladder cancer | May exacerbate congestive heart failure and CL in NYHA Class III and OV | |
| Glucagon-like Peptide-1 (GLP-1) Receptor agonist | Dulaglutide (SQ) | Trulicity | Type 2 DM | Nausea, vomiting, diarrhea, pancreatitis | May increase risk of thyroid c-cell tumor, Cl in personal or family history of medullary thyroid cancer and in patients with multiple endocrine neoplasia syndrome type 2 | |
| Glucagon-like Peptide-1 (GLP-1) Receptor agonist | Liraglutide (SQ) | Victoza, Saxenda | Type 2 DM, Chronic weight management | peripheral edema, weight gain, upper respiratory tract infection; increased risk of fractures and bladder cancer | May excerbate congestive heart failure and Cl in NYHA CLass III and IV | |
| Glucagon-like Peptide-1 (GLP-1) Receptor agonist | Semaglutide (PO, SQ) | SQ: Ozempic, Wegovy PO: Rybelsus, Wegovy | Type 2 DM, Chronic weight management | Nausea, vomiting, diarrhea, pancreatitis | May increase risk of thyroid c-cell tumor, Cl in personal or family history of medullary thyroid cancer and in patients with multiple endocrine neoplasia syndrome type 2 | |
| Dual GLP-1 and Glucose-dependent Insulinotropic Polypeptide (GIP) Agonist | Tirzepaide (SQ) | Mounjaro, Zepbound | Type 2 DM, Chronic weight management | Nausea, vomiting, diarrhea, constipation, pancreatitis | May increase risk of thyroid c-cell tumor, Cl in personal or family history of medullary thyroid cancer and in patients with multiple endocrine neoplasia syndrome type 2 | |
| Insulin, Long Acting | Insulin Glargine (SQ) | Lantus, Toujeo, Basaglar | Type 1 DM, Type 2 DM | Nausea, vomiting, diarrhea, constipation, increased heart rate, pancreatitis | May increase risk of thyroid c-cell tumor, Cl in personal or family history of medullary thyroid cancer and in patients with multiple endocrine neoplasia syndrome type 2 | |
| Insulin, Intermediate Acting | Insulin NPH (SQ) | Humulin N, Novolin N (OTC) | Type 1 DM, Type 2 DM | Hypoglycemia, weight gain | ||
| Insulin, Rapid Acting | Insulin Aspart (SQ) | Novolog, Flasp | Type 1 DM, Type 2 DM | Hypoglycemia, weight gain | ||
| Insulin, Rapid Acting | Insulin Lispro (SQ) | Humalog, Admelog, Lyumjev | Type 1 DM, Type 2 DM | Hypoglycemia, weight gain | ||
| Insulin, Short Acting | Insulin Regular (SQ, IV) | Humlin R, Novolin R (SQ:OTC) | Type 1 DM, Type 2 DM, DKA | Hypoglycemia, weight gain |
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