-job is suppression: prevent autoimmunity; immune response resolution; enforce tolerance -two types 1.Thymic (natural) T-regs/tTregs/nTregs 2. Peripheral (induced) Treg/pTreg/iTreg

1.Thymic (natural) T-regs/tTregs/nTregs -In thymus bind self-antigen poorly (weak, recognizes itself) -instead of delete -> repurposed to suppressor (ex. antihistamines)

2. Peripheral (induced) Treg/pTreg/iTreg -Naive CD4+ T-cells (left thymus) -encounter antigen in periphery - APC -became Treg via APC derived cytokines

Follicular Dendritic Cell

-long term whole antigen presentation -> binds opsonins (bacon bits) -express levels of Complement receptor 1 & 2 (CR1, CR2) captures complement bound antigen -display to Bcells for Darwinian selection in follicle of lymph node (somatic hypermutation)

Follicular dendritic cells and B-cells

B-cells that: -bind native antigen with high affinity -extract from FDC and internalize antigen -present on MHC II to Tfh cells Get: -survival signals Tcell help -another round of mutation -eventually become plasma and memory cells (Tfh)

Germinal centre - dark zone

-centroblasts -prolifferating B-cells - Somali hypermutation

Germinal centre - Light zone

-FDCs presenting antigen Tfh cells provide signals - select high affinity B cells - class switch if needed -success = exit as plasma or memory cell

Innate Lymphoid cells (ILC)

-lymphoid organ -tissue resident -innate immune cells (no TCR or BCR) -fast response -respond to stress signals from: alarmins (from epithelial cells), cytokines (from macrophage, DC, stroll cells), and stress/damage signals

Three types of Innate Lymphoid Cells

1. ILC-1 - sets stage for Th1 cells 2.ILC-2 - sets stage for Th2 cells 3. ILC-3 - like Th17 cells

1. ILC1 - sets stage for Th1 cells -intracellular pathogens -promote type 1 inflammation -activate macrophages via IFN-Y

2.ILC2 - sets stage for Th2 cells -extracellular pathogens -respond to epithelial damage -drives: Helminth defense (eosinophil recruitment) Mucus production Tissue repair

3. ILC-3 - like Th17 cells -Mucosal immunity -> tolerence -mucosa have the 'big guns' o the immune system -exposed to the most: food antigens, microbes, environmental pathogens -Therefor tolerance is important! - repair, promote tolerance

-structural cells of tissues -fibroblasts, endothelial cells, epithelial cells, mesenchymal stroll cells -communicate w/ immune cells via -cytokines -metabolites - tolerance signals

Help

Options

focusNode

Didn't know it?
click below

Knew it?
click below

Don't Know

Remaining cards (0)

Know

retry

shuffle

restart

0:00

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

Normal Size Small Size show me how

Lecture 6

Question	Answer
T regulatory cell	-job is suppression: prevent autoimmunity; immune response resolution; enforce tolerance -two types 1.Thymic (natural) T-regs/tTregs/nTregs 2. Peripheral (induced) Treg/pTreg/iTreg
Thymic T-reg	1.Thymic (natural) T-regs/tTregs/nTregs -In thymus bind self-antigen poorly (weak, recognizes itself) -instead of delete -> repurposed to suppressor (ex. antihistamines)
Peripheral T-reg	2. Peripheral (induced) Treg/pTreg/iTreg -Naive CD4+ T-cells (left thymus) -encounter antigen in periphery - APC -became Treg via APC derived cytokines
Follicular Dendritic Cell	-long term whole antigen presentation -> binds opsonins (bacon bits) -express levels of Complement receptor 1 & 2 (CR1, CR2) captures complement bound antigen -display to Bcells for Darwinian selection in follicle of lymph node (somatic hypermutation)
Follicular dendritic cells and B-cells	B-cells that: -bind native antigen with high affinity -extract from FDC and internalize antigen -present on MHC II to Tfh cells Get: -survival signals Tcell help -another round of mutation -eventually become plasma and memory cells (Tfh)
Germinal centre - dark zone	-centroblasts -prolifferating B-cells - Somali hypermutation
Germinal centre - Light zone	-FDCs presenting antigen Tfh cells provide signals - select high affinity B cells - class switch if needed -success = exit as plasma or memory cell
Innate Lymphoid cells (ILC)	-lymphoid organ -tissue resident -innate immune cells (no TCR or BCR) -fast response -respond to stress signals from: alarmins (from epithelial cells), cytokines (from macrophage, DC, stroll cells), and stress/damage signals
Three types of Innate Lymphoid Cells	1. ILC-1 - sets stage for Th1 cells 2.ILC-2 - sets stage for Th2 cells 3. ILC-3 - like Th17 cells
ILC-1	1. ILC1 - sets stage for Th1 cells -intracellular pathogens -promote type 1 inflammation -activate macrophages via IFN-Y
ILC-2	2.ILC2 - sets stage for Th2 cells -extracellular pathogens -respond to epithelial damage -drives: Helminth defense (eosinophil recruitment) Mucus production Tissue repair
ILC-3	3. ILC-3 - like Th17 cells -Mucosal immunity -> tolerence -mucosa have the 'big guns' o the immune system -exposed to the most: food antigens, microbes, environmental pathogens -Therefor tolerance is important! - repair, promote tolerance
Stromal cells	-structural cells of tissues -fibroblasts, endothelial cells, epithelial cells, mesenchymal stroll cells -communicate w/ immune cells via -cytokines -metabolites - tolerance signals

Created by: user-2017899

"Know" box contains:
Time elapsed:
Retries: