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Hormone Tx

Oncology Exam #3

Drug NameDrug ClassMOASide effectsDrug interactions
Goserelin GnRH agonists Continuous exposure to GnRH agonist will suppress LH/FSH pituitary secretion which then reduces testosterone production. (negative feedback)
Leuprolide GnRH agonists Continuous exposure to GnRH agonist will suppress LH/FSH pituitary secretion which then reduces testosterone production. (negative feedback)
Triptorelin GnRH agonists Continuous exposure to GnRH agonist will suppress LH/FSH pituitary secretion which then reduces testosterone production. (negative feedback)
Relugolix GnRH antagonist
Degarelix GnRH antagonist
Finasteride 5α-Reductase Inhibitors
Dutasteride 5α-Reductase Inhibitors
Abiraterone acetate P450c17 inhibitors
Anastrozole Aromatase Inhibitors
Letrozole Aromatase Inhibitors
Exemestane Aromatase Inhibitors
Tamoxifen Selective Estrogen Receptor Modulators (SERMs)
Raloxifene Selective Estrogen Receptor Modulators (SERMs)
Fulvestrant Selective Estrogen-Receptor Downregulators (SERDs)
Bicalutamide Selective Estrogen-Receptor Downregulators (SERDs)
Flutamide Selective Estrogen-Receptor Downregulators (SERDs)
Nilutamide Selective Estrogen-Receptor Downregulators (SERDs)
Enzalutamide Selective Estrogen-Receptor Downregulators (SERDs)
Apalutamide Selective Estrogen-Receptor Downregulators (SERDs)
Darolutamide Selective Estrogen-Receptor Downregulators (SERDs)
Inavolisib PI3K inhibitor Inhibitor of phosphatidylinositol 3-kinase (PI3K) which decreases cell proliferation and induces apoptosis
Zolendroic Acid Biphosphonates Binds to hydroxyapatite in bone which inhibits osteoclast-mediated bone resorption
Denosumab RANK ligand inhibitor Binds to RANKL, blocking RANKL binding to RANK on the surface of osteoclast precursor cells; inhibits osteoclastogenesis
Radium-233 Targeted radiation therapy Radioactive agent that emits alpha particles --> break DNA in adjacent cells --> kill them.
Sipuleucel-T Autologous cellular immunotherapy Induces an immune cell response against prostate acidic phosphatase (PAP), which is expressed in most prostate cancers
Created by: Kalinda
 

 



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