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Leverfuncties en hun markers • i. Eiwit synthese: albumine • ii. Regulatie van glucosemetabolisme: glucose • iii. Synthese stollingsfactoren (behalve VIII): PT, fibrinogeen, plasminogeen, proteïne C/S • iv. Detox: amoniak • v. Verwerken van afvalstoffen hemoglobine: bilirubine
definitie acute leverinsufficiëntie snel ontstaan van > 3 keer verhoging van transaminasen en coagulopathie (prothrombinetijd verlengd met 4 tot 6 seconden of langer; INR > 1,5) bij patiënt zonder chronische leverziekte
ALAT waar aanwezig en waardoor stijgt het? Veel aanwezig in hepatocyten (alleen cytoplasma) Weinig in skeletspier en hartspier. Zeer weinig in nier, pancreas, ery’s Functie: omzetting van alanine naar a-ketoglutaraat Verhoogd bij alle vormen van beschadiging hepatocyten
ASAT waar aanwezig en waardoor stijgt het? Veel aanwezig in hepatocyten (cytoplasma en mitochondriën) Veel aanwezig in hartspier en skeletspier Verhoogd bij alle vormen van beschadiging van hepatocyten
AF waar aanwezig en waardoor stijgt het? Aanwezig op de canaliculaire membraan van hepatocyten (tegen cholangiocyten aan) AF stijgt bij obstructie van galwegen en diffundeert vervolgens naar bloed
GGT (gammaglutamyltransferase) Indien naast AF ook GGT verhoogt -> suggereert hepatische oorzaak van verhoogd AF!
Hemoglobine
Created by: Ingmar
 

 



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