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Non-coding RNAs
Uni of Notts, Structure Function & Analysis of Genes, year 2, topic 9
| Term | Definition |
|---|---|
| Functions of ncRNAs (5) | Regulate gene expression Cellular immune defence against foreign nucleic acid Guide DNA synthesis or genomic rearrangement Catalytically (ribozyme or riboswitch) In protein scaffolds/complexes |
| ncRNA in genomic rearrangement | RNA templates of certain genes complex with chromatin remodelling & recombination enzymes to bring them to the desired target |
| Ribozymes | Enzymes composed of RNA to catalyse reactions like cleavage or ligation other RNA species by positioning the phosphodiester bond to utilise nucleophilic -OH group through folding |
| Riboswitches | Sensory genetic-regulatory element composed of RNA. Aptamer domain binds small metabolite, refolding favours 1 conformation over another. 1 conformation proceeds transcription/translation while the other inhibits |