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HIV final
| Question | Answer |
|---|---|
| List the PEP trx: | -raltegravir or dolutagravir PLUS 2 NRTIs (emtricitabine/ TDF) |
| apretude | cabotegravir |
| dovato | dolutgravir + lamivudine |
| descovy | emtricitabine + TAF |
| prezista | darunavir |
| triumeq | dolutegravir + lamuvidine + abacavir |
| truvada | emtricitabine + TDF |
| ziagen | abacavir |
| what is the complete ART therapy | Base: INSTI OR Boosted PI OR NNRTI NRTI backbone (2) : abacavir or tenofivir PLUS emtricitabine or lamivudine or INSTI + NRTI -dovato |
| biktarvy | bictgravir PLUS emtricitabine PLUS TDF |
| capsid inhibitor moa | 1. formation of the HIV inner capsid 2. assembly of viral proteins 3. entry of HIV inner capsid core into the cd4 cell nucleus by blocking capsid binding |
| maraviroc moa | binds to ccr5 coreceptor |
| how long should PEP be continued for? | 4 weeks |
| ADR for all NRTIs: | -lactic acidosis -hepatomegaly -nausea & diarrhea |
| tenofovir adr: | more so with tdf instead of taf: -nephrotoxicity (fanconi syndrome) -decrease BMD -lipid abnormalities (primarily with TAF) |
| what drugs are not rec if crcl <30? | -TAF containing products -dovato -triumeq |
| whatd rugs are not rec if crcl<50? | tdf exception: truvada can be dose adjusted; but not rec if crcl <30 |
| stribild | elvitegravir / cobicistat / emtricitabine / TDF |
| if crcl < 70 what is not rec? | stribild in pt receiving trx, it should be d/c when crcl <50 |
| what is not rec if crcl <60? | when used for HIV pre-or post exposure phx, truvada is not rec |
| when should you not use dovato? | if hiv pre-trx HIV RNA >500,000, there is known Hep B coinfxn, or genotyping is not available |
| best HIV med for trx naive pt? | -biktarvy -dovato -2 pill : tivicay + truvada OR tivicay + descovy |
| complera | rilpivirine + emtricitabine + TDF |
| symtuza | darunavir + cobicistat + emtricitabine + TAF |
| tivicay | dolutegravir |
| hiv testing rec for pt taking prep? | q 3 months |
| pt 13-64 with no other risk ; how often shold be tested for hiv? | once in their lifetime |
| odefsey | rilpvirine + emtricitabine + TAF |
| all nnrti adr? | -hepatotxicity & rash including sjs/TEN (highest with nevirapine) |
| efavirnez adr? | -cns sx -increase TC & TG |
| efavirnez administraion? | take on empty stomach and take at bedtime (decreases adr) |
| rilpivirine adr: | -depression -false elevations in scr (no effect on gfr) -im formulation (in combo w/ cabotegravir): inj site rxn |
| rilpivirine administeration? | -take w/ meal (must contian >390 kcal) -drug interactions with antacids / h2ras -avoid PPI |
| if taking an h2ra with ripivirine; when can you take it? | 12 hr before or 4 hours after taking rilpivirine |
| if taking an antacids with ripivirine; when can you take it? | 2 hours before or 4 hrs after |
| rilpivirine should be avoided in what? | cyp34a inducers |
| genvoya | elvitegravir + cobicistat + emtricitabine + TAF |
| all INSTI adr: | -weight gain -nervous system / psychiatric effects -interactions w/ polyvalent cations (take 2 hrs before or 6 hr after) |
| bictegravir adr: | increased scr |
| dolutegravir adr? | -muscle toxicity -increased scr -hsr rxn -hepatotoxicity |
| raltegravir adr: | -muscle toxicity -HSR rxn -SJS/TEN |
| list the one pill regimens? | -dovato -biktarvy - |
| list the 2 pills once daily regimen: | -tivicay + truvada -tivicay + descovy |
| cabenuva | cabotegravir + rilpvirine |
| delstrigo | doravirine + lamuvidine + tdf |
| epzicom | abacavir + lamivudine |
| what must be taken with cobicistat? | food |
| raltegravir | isentress |
| what IM HIV Prep med and how often? | apretude taken monthly x 2 doses, then q 2 months |
| list the boosters: | -ritonavir -cobicistat both with food |
| ritonavir dose | -norvir -100-200 po qd or bid w/ food |
| coicistat dose | 150 mg po qd w/ food |
| prep | truvada or descovy or apretude |
| pep | tivicay + truvada OR isentress + truvada |
| hiv medsd while preg? | -continue art OR -dolutegravir + 2 NRTIs OR -darunavir OR ritonavir PLUS 2 NRTIs |
Created by:
Nika1710