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Oncology Exam 1

Category Drug Name TargetADR BBWDDI/CI
Growth Factor Receptor Antagonist Gefitinib Reversible EGFR Asymptomatic increase in liver enzymes, interstitial lung disease
Growth Factor Receptor Antagonist Lapatinib Reversible EGFR, HER-2 Hepatotoxicity
Growth Factor Receptor Antagonist Tucatinib HER-2 Diarrhea, Hepatotoxicity
Growth Factor Receptor Antagonist Afatanib EGFR, HER-2, HER-4
Growth Factor Receptor Antagonist Osimertinib EGFR Interstitial lung disease/Pneumonitis, Pneumonia, Pulmonary Embolism
Growth Factor Receptor Antagonist Cetuximab EGFR rash, diarrhea Infusion reaction, Cardiopulmonary arrest
Growth Factor Receptor Antagonist Panitmumab EGFR Dermatologic Toxicity Fetal harm
Growth Factor Receptor Antagonist Trastuzumab HER-2 Cardio toxicity Cardiomyopathy, Pulmonary toxicity, Infusion reaction Warfarin, Fetal harm
Growth Factor Receptor Antagonist Ado-trastuzumab emtansine HER-2 Hepatotoxicity, Cardiotoxicity (decreased LVEF) Fetal harm
Growth Factor Receptor Antagonist Fam-trastuzumab deruxtecan-nxki HER-2 Interstitial lung disease/pneumonitis Fetal harm
Growth Factor Receptor Antagonist Pertuzumab HER-2 LVD Fetal harm
ALK Inhibitors Crizotinib ALK, ROS-1, MET Bradycardia, QTc prolongation, Interstitial lung disease/pneumonitis, hepatotoxicity
ALK Inhibitors Alectinib ALK, RET Visual Disturbances, Photosensitivity Fetal harm
ALK Inhibitors Brigatinib ALK, ROS-1, FLT-3, EGFR variants Visual Disturbances, Photosensitivity Fetal harm
ALK Inhibitors Ensartinib ALK, ROS-1, MET Visual Disturbances, Photosensitivity Fetal harm
ALK Inhibitors Lorlatinib ALK, ROS-1 Interstitial lung disease/pneumonitis, hepatotoxicity CI with strong 3A4 inducers, Fetal harm
FLT-3 Inhibitors Midostaurin FLT-3 (ITD/ITK) Fetal harm
FLT-3 Inhibitors Quizartinib FLT-3 (potent ITD) QTc prolongation, torsades de pointes, Cardiac arrest CI: severe hypokalemia, hypomagnesemia, Long QTc syndrome
TRK Inhibitors Larotrectinib TRK A/B/C Neurotoxicity/Hepatotoxicity
TRK Inhibitors Entrectinib TRK A/B/C, ROS-1, ALK kinases CHF, cognitive impairment, Hepatotoicity, QTc prolongation
TRK Inhibitors Repotrectinib TRK A/B/C, ROS-1 Neurotoxicity/Hepatotoxicity, Pneumonia
RET Inhibitors Selpercatinib (PO) RET, VEGFRs, FGFRs Impaired wound healing, hepatotoxicity, QTc prolongation
RET Inhibitors Pralsetinib (PO) Wild type and mutated RET Interstitial lung disease/pneumonitis, HTN
MET Inhibitors Capmatinib MET (exon 14) Peripheral edema
MET Inhibitors Tepotinib MET Peripheral edema
MET Inhibitors Amivantamab-vmjw EGFR, MET Fetal harm
BTK Inhibitors Acalabrutinib BTK DDI: PPI's, Antacids, 3A4 inhibitors
BTK Inhibitors Zanubrutinib BTK Myelosuppression, hemorrhaging
BCR-ABL Antagonists Imatanib BCR-ABL, PDGFR, KIT Neutropenia, thrombocytopenia
BCR-ABL Antagonists Nilotinib BCR-ABL, wild type
BCR-ABL Antagonists Bosutinib BCR-ABL, resistant variants
BCR-ABL Antagonists Ponatinib BCR-ABL, T3151
BCR-ABL Antagonists Dasatinib BCR-ABL, Wildtype, resistant variants
BCR-ABL Antagonists Asciminib BCR-ABL, wildtype, T3151`
BRAF Inhibitors Dabrafenib BRAF Severe dermatologic reaction, photosensitivity, QTc prolongation
BRAF Inhibitors Encorafenib BRAF Severe dermatologic reaction, photosensitivity, QTc prolongation Fetal harm
MEK Inhibitors Trametinib MEK1/2, V600E Skin toxicity, cardiomyopathy, HTN, Occular effects, Interstitial lung disease Fetal harm
MEK Inhibitors Binimetinib MEK1/2, V600E/K Fetal harm
Cyclin Dependent Kinase Inhibitors (CDK) Palbociclib CDK4/6 Neutropenia, Blood clots, PE, pulmonary toxicity CI: QTc prolonging drugs
Cyclin Dependent Kinase Inhibitors (CDK) Ribociclib CDK4/6 Neutropenia, Blood clots, PE, pulmonary toxicity CI: QTc prolonging drugs
Cyclin Dependent Kinase Inhibitors (CDK) Ademaciclib CDK4/6 Neutropenia, Blood clots, PE, pulmonary toxicity CI: QTc prolonging drugs
Angiogenesis Inhibitors Bevacizumab VEGF-A Bleeding, Proteinuria, HTN
Angiogenesis Inhibitors Thalidomide bFGF Thrombosis, neuropathy, constipation, myelosuppression, somnolence Teratogenic
Angiogenesis Inhibitors Lenalidomide bFGF Somnolence, thrombosis, myelosuppression
Immune Checkpoint Inhibitors Ipilimumab CTLA-4 Hepatitis, hypophysitis
Immune Checkpoint Inhibitors Pembrolizumab PD-1
Immune Checkpoint Inhibitors Nivolumab PD-1
Immune Checkpoint Inhibitors Cemiplimab-rwlc PD-1 immune related events, Hepatitis, Nephritis
Immune Checkpoint Inhibitors Durvalumab PD-L1 UTI, URTI
Immune Checkpoint Inhibitors Atezolizumab PD-L1 UTI, immune related effects, Gullian-Barre Syndrome Fetal harm CI: inpatients with urothelial carcinoma
Cell Surface Antigen Monoclonal Antibodies Rituximab CD20 Immunosuppression, Hypersensitivity
Cell Surface Antigen Monoclonal Antibodies Obinutuzumab CD20 Myelosuppression, HBV related and progressive PML
Cell Surface Antigen Monoclonal Antibodies Blinatumomab CD19/CD3 monitor for cytokine release syndrome, neruotoxicity, infection
BCL-2 Inhibitors Venetoclax BCL-2
Asparaginase Asparaginase Asparaginase Hypersensitivity, clottign abnormalities, hypoalbuminemia, suppression of immune function, COMA (rare)
Myeloid Growth Factor (MGF) GM-CSF Sargramostim
Myeloid Growth Factor (MGF) G-CSF Filgrastim
Myeloid Growth Factor (MGF) G-CSF Pegfilgrastim
Myeloid Growth Factor (MGF) G-CSF Efbemalenograstim alfa
CDK4/6 inhibitor Trilaciclib
Thrombopoietin Agonist Eltromopag
Thrombopoietin Agonist Romiplostim
Thrombopoietin Agonist Avatrombopag
Thrombopoietin Agonist CD20 killer Rituxumab
Thrombopoietin Agonist IVIG
Thrombopoietin Agonist RHO (D)
Synthesis Inhibitors GnRH Agonists Goserelin
Synthesis Inhibitors GnRH Agonists Leuprolide
Synthesis Inhibitors GnRH Agonists Triptolerin
Synthesis Inhibitors GnRH Antagonist Relugolix
Synthesis Inhibitors GnRH Antagonist Degarelix
Anti-Androgen (1st gen) Bicalutamide
Anti-Androgen (1st gen) Flutamide
Anti-Androgen (1st gen) Nilutamide
Anti-Androgen (2nd gen) Enzalutamide
Anti-Androgen (2nd gen) Apalutamide
Anti-Androgen (2nd gen) Darlutamide
PI3K inhibitor Inavolisib
Created by: Danielle9685
 

 



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