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PHO 3

BDK

Generic NameBrand NamePharmacologic CategoryCommon IndicationKey Side EffectsOther NotesUS Boxed WarningClassification
Methotrexate Trexall Antimetabolite (folic acid antagonist) Rheumatoid arthritis, Crohn's Disease, Psoriasis, Various hematologic & solid tumors Stomatitis, Diarrhea, Nausea, Vomiting, Thrombocytopenia, Leukopenia, Increased hepatic transaminases, Pulmonary fibrosis (rare) Folic acid supplementation may be taken during use to reduce hematologic, gastrointestinal, and hepatic side effects Serious toxic rxns;fetal death &/or congenital abnormalities (avoid in pregnancy);severe bone marrow suppression, aplastic anemia & toxicity have been reported w/ methotrexate & NSAIDs;hepatotoxicity;methotrexate-induced lung disease;GI toxicity w/ NSAID N/A
Cisplatin Kemoplat Antineoplastic agent, platinum-based compound Advanced bladder, ovarian, & testicular cancer; Various cancers Bone marrow suppression, Nausea, Vomiting, Nephrotoxicity, Neurotoxicity, Ototoxicity N/A May cause severe myelosuppression, nausea and vomiting, renal toxicity, and dose-related neuropathy N/A
Doxorubicin Adriamycin Antineoplastic agent, anthracycline Adjuvant therapy for breast cancer, Various cancers Cardiomyopathy, Alopecia, Nausea, Vomiting, Bone marrow suppression May cause red discoloration of urine, tears, sweat, & saliva May cause cardiomyopathy, myelosuppression, secondary malignancies; extravasation can result in severe local tissue injury and necrosis N/A
Pembrolizumab Keytruda Antineoplastic agent, monoclonal antibody Various cancers Peripheral edema, Pruritus, Skin rash, Endocrine & metabolic abnormalities, Constipation, Diarrhea, Nausea, Vomiting, Hematuria, Anemia, Increased liver enzymes, Fatigue, Musculoskeletal pain, Increased SCr, Dyspnea N/A N/A N/A
Anastrozole Arimidex Aromatase inhibitor Hormone receptor-positive breast cancer Fatigue, Rash, Flushing, Hot flashes, Arthralgia, Nausea, Vomiting, HTN, Peripheral edema, Osteoporosis CV side effects (i.e hypercholesterolemia, CAD); Fetal toxicity (CI in pregnancy) N/A N/A
Tamoxifen Soltamox Selective estrogen receptor modulator (SERM) Hormone receptor-positive breast cancer Hot flashes/night sweats, Vaginal bleeding/discharge, Decreased bone density (in premenopausal females) Contraception should be used in premenopausal females due to teratogenicity of the drug; Don't use w/ warfarin or history DVT/PE Increased risk for uterine or endometrial cancer & thromboembolic events N/A
Created by: jammers27
 

 



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