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PHO 1

BDK

Generic NameBrand NamePharmacologic CategoryCommon IndicationKey Side EffectsOther NotesUS Boxed WarningClassification
Fentanyl Transdermal: Duragesic IV: Sublimaze Opioid analgesic Pain Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Pruritus, Respiratory depression (dose-related) N/A Potential for med. errors when converting dosage forms; use w/ CYP3A4 inhibitors (or stopping inducers) can increase concentrations; avoid exposing transdermal patch to external heat Opioid analgesic BW (see morphine IR) CS-II
Hydromorphone Dilaudid Opioid analgesic Pain Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Pruritus, Respiratory depression (dose-related) N/A Risk of medication errors w/ high-potency hydromorphone, use in opioid-tolerant patients only; Opioid analgesic BW (see morphine IR) CS-II
Morphine ER MS Contin, Kadian Opioid analgesic Pain Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Pruritus, Respiratory depression (dose-related) N/A Coingestion w/ alcohol may result in potentially fatal overdose of morphine; Opioid analgesic BW (see morphine IR) CS-II
Morphine IR IV: Duramorph, Infumorph Opioid analgesic Pain Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Pruritus, Respiratory depression (dose-related) N/A Risk of opioid addiction, leading to overdose/death; Fatal respiratory depression; Long use in pregnancy = neonatal opioid withdrawal syndrome; Use w/ benzodiazepines or CNS depressants (including alcohol) = sedation, resp. depression, coma, death CS-II
Oxycodone OxyContin, Roxicodone Opioid analgesic Pain Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Pruritus, Respiratory depression (dose-related) N/A Use w/ CYP3A4 inhibitors (or stopping inducers) can increase concentrations; Opioid analgesic BW (see morphine IR) CS-II
Methadone Dolophine Opioid analgesic Opioid use disorder, severe chronic pain QTc prolongation, Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Respiratory depression (dose-related) N/A QTc interval prolongation & serious arrhythmia (Torsades de Pointes) have occurred during treatment; Concomitant use w/ CYP3A4, 2B6, 2C19, or 2D6 (or stopping inducers) can increase concentrations Opioid analgesic BW (see morphine IR) CS-II
Acetaminophen PO/PR: Tylenol IV: Ofirmev Non-opioid analgesic, antipyretic Pain, fever Nausea, Vomiting, Increased hepatic transaminases N/A Total daily dose from all sources shouldn't exceed max daily limit; hepatotoxicty PO/PR: OTC
Tramadol Ultram, Ultram ER Central analgesic; partial opioid agonist Pain Dizziness, Drowsiness, Nausea, Vomiting, Constipation, Respiratory depression (dose-related) Lowers seizure threshold Resp. depression & death in children after tonsillectomy/adenoidectomy who are ultra-rapid metabolizers. Use or D/C of 3A4 inducers, inhibitors, or 2D6 inhibitors requires consideration. Risk of opioid addiction = overdose/death. (more not listed) CS-IV
Created by: jammers27
 

 



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