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CNS 5
BDK
| Generic Name | Brand Name | Pharmacologic Category | Common Indications | Key Side Effects | Other Notes | US Boxed Warning | Classification |
|---|---|---|---|---|---|---|---|
| Buspirone | Buspar | Antianxiety agent | Anxiety | Dizziness, Drowsiness, Nausea | Don't use w/ MAOI | N/A | N/A |
| Alprazolam | Xanax | Benzodiazepine | Anxiety | Daytime sedation, Performance impairment, Tolerance, Dependence, Withdrawal, Ataxia, Anterograde amnesia, Dizziness | N/A | Risk of profound sedation, respiratory depression, coma & death w/ opioids, abuse, misuse, & addiction, dependence & withdrawal reactions | CS-IV |
| Clonazepam | Klonopin | Benzodiazepine | Anxiety, seizure disorders | Daytime sedation, Performance impairment, Tolerance, Dependence, Withdrawal, Ataxia, Anterograde amnesia, Dizziness | N/A | Risk of profound sedation, respiratory depression, coma & death w/ opioids, abuse, misuse, & addiction, dependence & withdrawal reactions | CS-IV |
| Diazepam | Valium | Benzodiazepine | Anxiety, seizure disorders, acute alcohol withdrawal | Daytime sedation, Performance impairment, Tolerance, Dependence, Withdrawal, Ataxia, Anterograde amnesia, Dizziness | N/A | Risk of profound sedation, respiratory depression, coma & death w/ opioids, abuse, misuse, & addiction, dependence & withdrawal reactions | CS-IV |
| Lorazepam | Ativan | Benzodiazepine | Anxiety, seizure disorders, acute alcohol withdrawal | Daytime sedation, Performance impairment, Tolerance, Dependence, Withdrawal, Ataxia, Anterograde amnesia, Dizziness | IV: Parenteral formulation contains propylene glycol and may be associated w/ toxicity if used >/= 48 hours | Risk of profound sedation, respiratory depression, coma & death w/ opioids, abuse, misuse, & addiction, dependence & withdrawal reactions | CS-IV |
| Midazolam | Versed | Benzodiazepine | Anesthesia, sedation | Apnea, Bradypnea, Hypotension | N/A | Risk of profound sedation, respiratory depression, coma & death with opioids or when used for sedation in noncritical settings, abuse, misuse, & addiction, dependence & withdrawal reactions; Dose individualized; No rapid injection in neonates | CS-IV |
| Zolpidem | PO: Ambien, Ambien CR SL: Edluar | Hypnotic | Insomnia | Decreased ability to function the next morning, Parasomnias, Anterograde amnesia, Somnolence, Headache, Dizziness, Xerostomia | N/A | Serious injuries, including death, have occurred because of complex sleep behaviors (i.e., sleepwalking, sleep driving, and engaging in other activities while not fully awake); CI in patients with history of complex sleep behaviors | CS-IV |
| Melatonin | N/A | Sleep aid | Insomnia, jet lag | Daytime somnolence, Drowsiness | N/A | N/A | OTC |
| Propofol | Diprivan | Sedative, general anesthetic | Sedation for mechanical ventilation, procedural anesthesia, status epilepticus | Hypertriglyceridemia, Propofol-related infusion syndrome (rare), Bradycardia, Hypotension | Formulated as a 10% lipid emulsion containing 1.1 kcal/mL | N/A | N/A |
| Dexmedetomidine | Precedex | Alpha2 agonist, sedative | Sedation for mechanical ventilation or procedures | Bradycardia, Hypotension | Tolerance and tachyphylaxis may occur if used longer than 24 hours | N/A | N/A |