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CNS 3
BDK
| Generic Name | Brand Name | Pharmacologic Category | Common Indication | Key Side Effects | Other Notes | US Boxed Warning | Classification |
|---|---|---|---|---|---|---|---|
| Lithium | Lithobid | Antimanic agent | Bipolar disorder | Tremor, Acne, Hypothyroidism, Polyuria, Polydipsia, GI upset, Weight gain | Narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic drug monitoring is recommended); Avoid in pregnancy | Ability to promptly monitor levels is necessary | N/A |
| Sumatriptan | Imitrex | Antimigraine | Migraine | Chest tightness, Paresthesias, Fatigue, Somnolence, Dizziness | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, & uncontrolled HTN | N/A | N/A |
| Rizatriptan | Maxalt | Antimigraine | Migraine | Chest tightness, Paresthesias, Fatigue, Somnolence, Dizziness | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, & uncontrolled HTN | N/A | N/A |
| Haloperidol | Haldol | 1st gen. antipsychotic | Schizophrenia | Parkinsonism, Xerostomia, QTc prolongation, Sedation, EPS, Orthostatic hypotension, Weight gain | N/A | Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |
| Clozapine | Clozaril | 2nd gen. antipsychotic | Treatment resistant schizophrenia | Sialorrhea, Neutropenia, Hyperglycemia, Sedation, Constipation, Orthostatic hypotension, Weight gain | N/A | May cause severe neutropenia, orthostatic hypotension, bradycardia & syncope, seizures, fatal myocarditis & cardiomyopathy; Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |
| Aripiprazole | PO/IM: Abilify IM: Aristada | 2nd gen. antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Akathisia, Restlessness, Sedation, EPS, Constipation, Orthostatic hypotension, Weight gain | N/A | Antidepressants increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |
| Quetiapine | Seroquel, Seroquel XR | 2nd gen. antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Sedation, EPS, Constipation, Orthostatic hypotension, Weight gain | N/A | Antidepressants increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |
| Lurasidone | Latuda | 2nd gen. antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Sedation, EPS, Constipation, Orthostatic hypotension, Weight gain | CI w/ strong 3A4 inhibitors & inducers | Antidepressants increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |
| Olanzapine | Zyprexa | 2nd gen. antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Hyperglycemia, Sedation, EPS, Xerostomia, Constipation, Orthostatic hypotension, Weight gain | N/A | Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |
| Risperidone | PO: Risperdal IM: Risperdal Consta | 2nd gen. antipsychotic | Schizophrenia | Hyperglycemia, Sedation, EPS, Xerostomia, Constipation, Orthostatic hypotension, Weight gain | N/A | Elderly patients w/ dementia-related psychosis treated w/ antipsychotic drugs at increased risk of death | N/A |