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psych cg 28

QuestionAnswer
Benign prostatic hyperplasia Noncancerous, abnormal increase in the growth of the prostate gland Symptoms: ⮚ Weak or slow stream of urine ⮚ Delay in starting urination ⮚ Urinary frequency or urgency ⮚ Need to strain to urinate ⮚ Incomplete bladder emptying
Prostate-specific antigen Protein produced by the prostate gland. Levels are elevated in men with conditions ranging from prostate infection to prostate cancer
Prostate-specific antigen test Blood test to measure the percentage of prostate-specific antigen that is unbound. Free prostate-specific antigen is linked to benign prostate hyperplasia but not to cancer
•Alfuzosin •Doxazosin •Terazosin •Tamsulosin •Silodosin Alpha1-Adrenergic Antagonists
•Bind to alpha1-receptor sites: ⮚ Control prostate muscle tone ⮚ Block adrenergic-mediated vasoconstriction Alpha1-Adrenergic Antagonists moa
•Dutasteride •Finasteride •Dutasteride + tamsulosin (combination) 5α-Reductase Inhibitors
: •Reduce prostate growth and size •Inhibit 5alpha-reductase which blocks DHT (Hormone that stimulates prostate growth) 5α-Reductase Inhibitors moa
(transurethral resection of the prostate) Nonpharmacological Treatment Option TURP
Nonpharmacological Treatment Option TUIP (transurethral incision of the prostate)
Nonpharmacological Treatment Option TUMT (transurethral microwave thermal therapy of the prostate)
Nonpharmacological Treatment Option HoLEP (holmium laser enucleation of prostate)
•Sildenafil •Tadalafil •Vardenafil Phosphodiesterase Inhibitors
Selective inhibitors of cyclic guanosine monophosphate (cGMP) specific PDE5: ⮚ Relax smooth muscle and blood vessels ⮚ Increase levels of nitric oxide• Blocks the opening of calcium voltage-gated channels • Reduces calcium-mediated vascular contractions moa Phosphodiesterase Inhibitors
Alprostadil ⮚ A naturally occurring prostaglandin E1 in the seminal vesicles and cavernous tissues of males Prostaglandins
Mobilizes intracellular calcium: ⮚ Causes smooth muscle contraction •Mediates the release of nitric oxide in endothelium: ⮚ Relaxes cavernosal smooth muscle and causes erection Prostaglandins moa
may worsen ED BUT 1MG DAILY IS USED FOR HAIR LOSS 5α-Reductase Inhibitors Finasteride
Created by: user-1991937
 

 



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