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psych ch 31

QuestionAnswer
Metastasis Spread of cancer from one part of the body to another
Neoplasm a tumor
Polyp Growth that protrudes from a mucous membrane
Prostate-specific antigen test: Test that measures the level of free prostate-specific antigen, a protein produced by the prostate gland. Levels are elevated in men who have prostate cancer, infection or inflammation of the prostate gland, and benign prostatic hyperplasia.
risk for breast cancer Nulliparity = never having given birth. history of hormone replacement therapy Early onset of menses = starting menstrual periods at a young age family history, age
most common form of cancer lung cancer
Small cell lung cancer cause caused by smoking
Cervical cancer linked to: Human papillomavirus ⮚ Exposure to drug DES (diethylstilbestrol, a synthetic estrogen.) while in uterus
•Selective estrogen receptor modulators treats breast cancer Tamoxifen ⮚ Toremifene
treats breast cancer ⮚ Fulvestrant Estrogen-receptor Antagonist
Aromatase Inhibitors •Anastrozole •Exemestane •Letrozole •Blocks action of aromatase
•Progestin treats advanced breast cancer - Megestrol acetate Suppression of LH release from pituitary •Increased metabolism of estrogen
•Gonadotropin-releasing hormone agonist treats advanced breast cancer ⮚ Goserelin Moa: Suppression of LH and FSH Marked reduction in estrogen production
Alkylating Agents Cyclophosphamide •Busulfan •Ifosfamide •Melphalan •Mechlorethamine •Chlorambucil MOA •Substitute an alkyl group on the amino acids guanine or cytosine •Impair DNA replication and the growth phase of the cell life
Taxanes •Docetaxel •Paclitaxel •Nanoparticle albumin-bound paclitaxel
Vinca Alkaloids •Vinorelbine •Vinblastine •Vincristine
Microtubule-Targeting Drugs Eribulin •Estramustine •Epothilone: ⮚ Ixabepilone •Taxanes •Vinca alkaloids
Anthracyclines •Doxorubicin •Doxorubicin liposomal •Epirubicin
Topoisomerase Inhibitors •Etoposide •Teniposide •Irinotecan •Topotecan
Platinum compounds: “-platin” Carboplatin •Cisplatin •Oxaliplatin
Fluoropyrimidines •5-Fluorouracil •Capecitabine •Cytarabine, liposomal •Fludarabine •Gemcitabine
Antimetabolites Methotrexate •Pemetrexed •6-Mercaptopurine •6-Thioguanine
Antimetabolites: MOA form abnormal nucleic acid–base pairs: ⮚ Create abnormal DNA •Methotrexate: ⮚ Depletion of thymidine ⮚ DNA synthesis ceases ⮚ Cell death
Created by: user-1991937
 

 



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