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BIOL 1101 Final
In-Class Notes, Cell Cycle and Mitosis
| Question | Answer |
|---|---|
| What is a phosphorylated ERK | enters the nucleus to control expression of genes in cell division & poliferation |
| What is Wnt & EGF do? | activates a series of transcription factors that lead to the expression of Cyclin D |
| What cyclin corresponds to G1? | cyclin D |
| What cyclin corresponds to S phase? | cyclin E |
| What cyclin corresponds to G2? | cyclin A |
| What cyclin corresponds to mitosis? | cyclin B |
| What are the functions of activated CDKs? | phosphorylate target proteins that activate DNA replication, mitosis, and cytokinesis |
| Which CDK does cyclin D correspond to? | CDK4 |
| Which CDK does cyclin E correspond to? | CDK2 |
| Which CDK does cyclin A correspond to? | CDK2 |
| Which CDK does cyclin B correspond to? | CDK1 |
| What occurs after the S-phase/at the end? | two chromatids attached to each othr by protein bridge |
| When does condensation of DNA start? | propahase |
| When does DNA replication start? | in Sphase |
| What is spinale? | web of microtubules that anchor at centrioles at poles of cell |
| What do spinale attach to and their function | attach to chromosomes and direct their movement |
| What occurs at prometaphase | nuclear envelope fragments, MTs enter nucleus, kinetochore established in each chromosome pair, microtubules attach to kinetochores, non-kinetochore MTs interact with opposite pole MTs |
| What occurs at metaphase? | chromosomes align at metaphase and metaphase plate |
| What occurs at anaphase? | kinetochore microtubules shorten and non-kinetochore microtubules lengthen, sister chromatids separate and move to opposite poles |
| What is an anaphase-promoting complex (APC)? | ligase that targets mitotic cyclin and securin for degradation |
| What occurs at telophase? | chromosomes reach cell poles, kinetochores disappear, non-kinetochore microtubules continue to elongate, nuclear membrane reforms, chromosomes decondense |
| What occurs at cytokinesis? | microfilaments form around cell -> make cleavage furrow -> pinched an two cells form |
| What occurs in cytokinesis in plants? | carbohydrate-rich vesicles -> form around center of cells -> vesicles fuse -> cell plate begins to form |