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A&P final

QuestionAnswer
Chapter 15 the male reproductive system
Word roots and combining forms
Andr/o - male
Crypt/o - hidden
Epididym/o - epididymis
Orch/o, orchi/o, and orchid/o - testes testicles
Pen/o - penis
Prostat/o - prostate
Semin/i - semen
Sperm/o, and Supermat/o - sperm
Test/o - testis testicle
Vas/o - duct vas deferens
Overview
All humans start from a zygote
Gender is determined by the 23rd pair of chromosomes which are the sex chromosomes
All eggs are an X chromosome the sperm can be x or y so the sex of the child is determined by the sperm of the father
The sry gene on the Y chromosome codes for a protein so that androgen receptors are produced in a male fetus
Testosterone and androgen receptors are needed in the fetus for male anatomy to develop
Male reproductive system
Major organs
Testes
Accessory structures
Scrotum
Spermatic ducts
Epididymis
Ductus deferens
Accessory glands
Seminal vesicles
Prostate gland
Bulbourethral glands
Penis
Functions
Production and delivery of sperm
Secretion of sex hormones
Male reproductive anatomy
Testes
Testes belong to the endocrine and reproductive systems because they produce testosterone and sperm
Testes descend from the abdomen to the scrotum because of the gubernaculum
The testes descend through an opening in the abdominal wall called the inguinal canal
For the testes to produce viable sperm the temperature of each testis must be approximately 2 degrees celsius cooler than the core body temperature which is the reason for they descend into the scrotum
Each testis has an outer fibrous capsule called the tunica albuginea
Sperm are produced in the seminiferous tubules
Interstitial cells located between seminiferous tubules produce testosterone
Secondary sex organs and structures
Scrotum
Spermatic cord
Spermatic duct
Accessory glands
Penis
Secondary sex organs and structures
Scrotum
The testes are housed in the scrotum
Dartos muscle - smooth muscle wall of the scrotum that reacts to temperature changes by contracting and relaxing
If it’s warm it relaxes maximizing the space for the testes to keep them cool
If it’s cool it contracts reducing the space in the scrotum to keep them warm
Spermatic cord
Suspends each testis and contains
Cremaster muscle - outer layer of the spermatic cord that completely covers the testis regulates the temperature for the testes
Ductus deferens - tube that carries sperm
Testicular artery - carries warm blood to the testes
Pampiniform plexus - cools the warm blood from the testicular artery
Spermatic ducts
Efferent ductules - carries sperm from the testes to the epididymis
Epididymis - location of sperm maturation and storage
Ductus deferens - merges with the seminal vesicle to form the ejaculatory duct
Ejaculatory ducts - carries sperm from the ductus deferens to the urethra
The 5 accessory glands in the male are
2 seminal vesicles - secretes a thick yellowish fluid mixture of sugar and protein that makes up 60% semen
1 prostate gland - surrounds the urethra inferior to the bladder that produces a thin whitish alkaline mixture containing prostaglandins that makes up 30% semen
2 bulburethral glands - produce a small amount of slightly alkaline lubricant that makes intercourse easier and neutralizes the ph of the male urethra
Penis
Penis has an internal root and an external shaft and glans
Glands contain many nerve endings for sexual stimulation it’s covered by prepuce (foreskin)
Prepuce is surgically removed during a circumcision
Penis is composed of 3 columns of erectile tissue
2 columns of corpora cavernosa that have large spaces
1 column of corpus spongiosum that has smaller spaces
Anatomy of a sperm
Spermatozoon is a single cell with 2 principal parts - head and tail
Head contains 23 chromosomes and use an enzyme-filled acrosome cap used to penetrate an egg
Tail contains a midpiece (with large mitochondria) to supply ATP to energize the tail the function of the tail is to propel the sperm
Physiology
Testosterone production ceases a few months after birth and doesn’t resume until puberty
Puberty begins with the production of FSH and LH at approximately 10-12 in body and it ends usually 2-4 years after puberty starts
Hormone control at puberty
FSH stimulates sustentacular cells in the seminiferous tubules to produce androgen-binding protein (ABP)
ABP and testosterone are needed for testosterone to have an effect on sperm production
LH stimulates interstitial cells to produce testosterone
Male secondary sex characteristics
Skeletal and muscle development
Changes in the larynx that cause a deeper voice
Development of axillary and pubic hair with activation of associated apocrine glands
Development of facial hair and possible thickening of hair on the torso and limbs
Aggression
Development of the libido (sex drive)
Sperm production
Mitosis is a one-division process that forms all body cells
Parent cell of 46 chromosomes replicates and divide to produce 2 daughter cells
Each daughter cell has a set of 46 chromosomes that is identical to the other daughter cell set
Meiosis is a two-division process that starts with a parent cell of 46 chromosomes
Meiosis 1 - forms daughter cells with an independent assortment of chromosomes through crossing-over
Meiosis 2 - 4 cells are produced each having half the number of chromosomes (haploid) as the original parent cell
Sperm production involves 2 processes - spermatogenesis and sperminogenesis
Spermatogenesis
Produces 4 cells (each with 23 chromosomes) from a specialized stem cell with 46 chromosomes
Male germ cell is known as spermatogonia
Steps
Spermatogonium near the basement membrane of the seminiferous tubule divides by mitosis producing 2 identical spermatogonia
1 remains (A) near the basement membrane to serve as a spermatogonium later
The other spermatogonium (B) migrates slightly away from the wall toward the lumen of the seminiferous tubule it will continue on in the production process
Spermatogonium B enlarges to become a primary spermatocyte
Once protected by the blood-testis barrier the primary spermatocyte goes through meiosis 1
This produces two equal-size genetically unique secondary spermatocytes each having 23 chromosomes
Each secondary spermatocyte undergoes meiosis 2 which produces in total 4 spermatids from the 1 original spermatogonium type b
Spermiogenesis
Sperm production transforms soermatids to functional sperm
Each spermatid forms a tail and sheds its cytoplasm to become a sperm
Goes to epididymis to mature
Hormone control in the adult male
Testosterone has a positive effect on many tissues but it also has a negative-feedback effect on the hypothalamus (by inhibiting GnRH) and the anterior pituitary (by reducing its sensitivity to GnRH)
Sustentacular cells produce the hormone inhibin when they are busy with sperm production so that FSH from the anterior pituitary is inhibited
Pathway for sperm
Seminiferous tubules
Rete testes
Efferent ductules
Epididymis
Ductus deferens
Ejaculatory ducts
Urethra
Outside the body
Sexual response in the male
4 stages
Arousal results in an erection neural signs cause the arteries in the penis to dilate so the penile erectile tissues fill with blood bulbourethral glands secrete their fluid
Emission sperm moves by peristaltic contractions through the ductus deferens to its ampulla through the ejaculatory duct to the urethra prostate and seminal vesicles secrete their fluids
Ejaculation orgasm occurs (increased heart rate and blood pressure) and sperm are forcefully expelled from the urethra
Resolution excess blood is forced from the penis thus causing it to become flaccid arteries that bring blood to the penis are constricted
Effects of aging
Testosterone production peaks at 20 and decline from there so at 80 a male may make only 20% of the testosterone he produced at his prime
Sperm production continues into old age
Increased FSH and LH levels rise significantly after 50 producing andropause in which men can experience hot flashes and mood swings
Erectile dysfunction occurs in about 20% of men in their 60s and increases to 50% of men in their 80s
80% of men have benign prostatic hyperplasia by 80
Enlargement of the prostate (grows toward the middle) that compresses the urethra and makes micturition difficult
Common diagnostic tests
Digital rectal exam - procedure in which the doctor inserts fingers into the rectum to detect any abnormalities
Lab test/microscopic exam of samples - procedures that involve collecting urine or specimen samples from the urinary tract to determine the presence of viruses or bacteria that may cause infection
PSA test - test the measures the presence of prostate-specific antigens in the blood increased levels may indicate prostate cancer
Transrectal ultrasound and biopsy of the prostate - procedure in which ultrasound tech is used to assess the prostate for evidence of cancer if a mass is detected a sample is collected and examined by a lab for the presence of cancerous cells
Ultrasound - cause of hydrocele examine a mass in the testis and diagnose epididymitis and cryptorchidism
Male reproductive system disorders
Prostate cancer
90% of men over 50 will develop prostate cancer
Can be detected by a digital rectal exam and a blood test that measures PSA levels
Testicular cancer
Most common in white males between 15-34
Routine testicular self-exams are recommended for early detection
Hypospadias is a congenital defect in which the urethra opens on the ventral side or base of the penis instead of on the tip of the glans
Epididymitis - inflammation of the epididymis usually caused by a bacterial infection
Phimosis - tight foreskin that can’t be pulled back over the glans penis
Hydrocele - fluid has accumulated and causes swelling in the scrotum
Male reproductive disorders
Cryptorchidism - condition of undescended testes in male infants
Chlamydia - std caused by the chlamydia trachomatis bacteria
Gonorrhea - std caused by the neisseria gonorrhea bacteria
Syphilis - std caused by the treponema pallium bacteria
Infertility - inability to fertilize an egg
Chapter 16 female reproductive system
Word roots and combining forms
amni/o - amnion
cervic/o - cervix neck
chorion/o - chorion
episi/o - vulva
gynec/o - female
hyster/o - uterus
lact/o - milk
mamm/o - breast
mast/o - breast
men/o - menses menstruation
metr/o, metri/o - uterus
o/o and ov/o - egg
oophor/o - ovary
ovari/o - ovary
ovul/o - egg
salping/o - uterine tube
uter/o - uterus
vagin/o - vagina
vulv/o - vulva
Overview
Female zygote has xx as the sex chromosome
Without the SRY gene on the Y chromosome and therefore the lack of androgen receptors and testosterone a zygote develops female reproductive anatomy
Ovaries produce ova and are therefore the primary sex organs of the female reproductive system
Ovaries are enclosed in a capsule called the tunica albuginea
Anatomy
Ovaries
Belong to the reproductive and endocrine systems
Ovary has 2 layers - cortex containing follicles and a medulla containing blood vessels
Ligaments suspend the ovaries in the pelvic cavity and anchor them to the uterus
Broad ligament - extension of the peritoneum
Ovarian ligaments- attaches the medial edge of the ovary to the uterus
Suspensory ligament - attaches the lateral edge of the ovary to the posterior wall of the pelvic cavity
Round ligament
Secondary female reproductive organs and structures
Ovaries uterus and vagina are internal
Vulva and breasts are external
Uterus is held in place by the broad and round ligaments and expands with pregnancy
Thick wall has 3 layers
Perimetrium - outer layer known as the visceral peritoneum
Myometrium - thick layer of smooth muscle that contracts to expel uterine contractions
Endometrium - inner lining made up of 2 sublayers
Stratum basalis - deep ⅓
Stratum functionalis - superficial ⅔
Uterus has 3 regions
Fundus - broad superior curve
Body - wide mid portion
Cervix - inferior (neck) region
Uterine tubes transport eggs to the uterus
Also called fallopian tube or oviduct
Ends called infundibulum has fimbriae which coax the eggs into the uterine tube
Lined by ciliated cells
Vagina allows for the flow of the menses is a receptacle for sperm and serves as the birth canal
External vaginal opening is covered by the hymen
Lining is stratified squamous epithelial tissue
Vulva includes the following
Mons pubis - pubic hair cover mound of adipose tissue superficial to the pubic symphysis
Labia - includes labia major and minora
Frames the vestibule
Clitoris
Erectile tissue - external portion is glans
Vestibular bulbs - erectile tissue in labia majora
Vestibular glands - lubricating glands in posterior vestibule similar to the bulbourethral glands in the male
Breasts contain mammary glands that don’t fully develop until the 1st pregnancy
Process of producing milk called lactation
Breast tissue supported by suspensory ligaments
Dark skin around nipple called areola
Small bumps in the areola are called areolar glands they secrete a substance to prevent chafing and cracking of the nipple during nursing
Laciteferous ducts drain the milk from the breast
Hormonal control of puberty
Puberty begins between 8-10 for most girls
Puberty begins when the GnRH from the hypothalamus stimulates the anterior pituitary to secrete FSH & LH
FSH stimulates follicles in the ovaries to produce estrogen
Estrogen is responsible for the development of female sex characteristics
Female secondary sex characteristics
Breast development
Development of axillary (armpit) and pubic hair
Widening of the pelvis
Fat deposition
Menstruation
Physiology of the female reproductive system
Oogenesis - egg production
1 haploid gamete is formed from each oogonium
Follicle is responsible for carrying for an oocyte and producing hormones
All oocytes have been produced from oogonia by birth
Many oogonia and oocytes are lost by atresia
Oogenesis is halted mid-meiosis 1 until puberty which means the primary oocyte remains dormant until adolescence
Primary oocyte is diploid which means it has 46 chromosomes
Secondary oocytes are formed each month
Meiosis 1 also produces a polar body
Meiosis 2 isn’t completed until an egg is fertilized
Follicles develop along an oocyte
Some primordial follicles develop each month after puberty
Mature graafian follicles rupture to release an egg during ovulation
After ovulation the follicle becomes a corpus luteum which secretes hormones to support the pregnancy if the egg is fertilized
If the egg doesn’t become fertilized the corpus luteum stops secreting hormones within 2 weeks and becomes a corpus albicans
Hormone control in the adult female
Female reproductive cycle is typically 28 days and begins on the 1st day of a women’s period
Composed of 2 parts
Ovarian cycle - affects the oocytes in the ovary
Menstrual cycle - affects the endometrial ring of the uterus
Ovarian cycle has 2 phases
Follicular phase days 1-14
Anterior pituitary secretes FSH which targets the primordial follicles to secrete estrogen
Estrogen levels peak just before day 14
Luteal phase days 14-28
Ruptured follicle remains in the ovary and becomes a corpus luteum
Corpus luteum secretes estrogen and progesterone which causes FSH & LH production to be inhibited (called negative feedback)
Menstrual cycle has the following phases
Menstrual day 1-5
Proliferative day 5-14
Estrogen is secreted by the follicle which targets the uterine lining to thicken
Secretory days 14-26
High levels of estrogen and progesterone cause the lining of the uterus to thicken
Endometrial glands secrete glycogen a nutritional source for the fertilized egg
Premenstrual day 26-28
Estrogen and progesterone levels decrease causing PMS
Ovulation typically occurs on day 14
So your cycles are determined by whether the egg is fertilized or not
If the egg is fertilized it happens in the uterine tubes and the corpus luteum continues to secrete hormones
If the egg isn’t fertilized the corpus luteum shrinks stops secreting hormones and turns into a corpus albicans
Corpus luteum knows what to do because the fertilized egg secretes HCG this is the hormone that’s detected in a home pregnancy test
Female sexual response
4 stages
Arousal - innermost part of the vagina dilates and the vaginal lining and vestibular glands secrete fluid that lubricates the vestibule and vagina to make intercourse easier
Plateau - lower ⅓ of the vagina constricts around the penis due to the engorgement of the vestibular bulbs clitoris becomes engorged with blood
Orgasm - uterus undergoes peristaltic contractions that cause the cervix to dip down into the possible pool of semen which helps facilitate the journey for the sperm
Resolution - reproductive anatomy returns to pre-arousal stage
Unlike the male a women doesn’t have a refractory period in her sexual response
Aging effects
Woman’s body goes through a climacteric in midlife due to the decreased production of estrogen and progesterone
Menstruation ceases during menopause
Hot flashes are common caused by lower levels of estrogen and progesterone
Tissues of the vagina labia minora clitoris uterus uterine tubes and breasts atrophy the thinning of the vagina and decreased secretions may cause dryness and make intercourse painful
Yeast infections become more common
Bone mass declines
Muscle and connective tissue decrease can cause sagging breasts prolapse of bladder (which causes incontinence) and difficult bowel movements
Skin becomes thinner
Cholesterol levels rise
Diagnostic tests
Biopsy - procedure in which tissue is collected and examined for the presence of abnormal cells
Blood test - reveal hormone levels pregnancy and presence of infection
Colposcopy - procedure in which a lighted colposcope is used to visualize the vagina and cervix
Hysteroscopy - procedure in which a lighted hysteroscope is used to visualize the uterus
Lab tests - procedure that involves collecting urine or specimen samples from the female reproductive tract to determine the presence of viruses or bacteria that may cause infection
Laparoscopy - procedure in which a lighted laparoscope is used to visualize collect biopsies from or perform surgical procedures in the abdomen or pelvic regions
Mammogram - x ray of the breast that’s used in screening for breast cancer or disease
Pap smear - part of the gynecological exam that helps detect abnormal cells in the lining of the cervix
Pregnancy test - test that detects hCG hormone in pregnant woman
Ultrasound - determine whether a woman is pregnant or detect any structural abnormalities of the reproductive organs and the developing fetus
Disorders
Breast cancer
Abnormal growth of breast tissue usually occurring in the lactiferous ducts and lobules of the breast
Age family history genetic mutations personal history and lifestyle choices affect breast cancer risk
Treatment may include chemo surgery radiation immunotherapy and hormone therapy
Mastectomy - removal of the breast
Lumpectomy - removal of the tumor of the breast
Mammograms
Detection of breast cancer usually begins with a monthly self-exam and mammography
Ovarian cancer
Cancer of the ovaries
Often lack symptoms
Difficult to diagnose
Treatment options include surgery chemo and radiation
Cervical cancer
Slow growing cancer that has few symptoms
Caused by HPV infection
Usually detected with a pap smear
Treatment options include removal of the uterus
Hysterectomy (removal of the uterus)
Fibroids
Noncancerous growths composed of muscular and fibrous tissue
Found in the uterus endometrium or on the outside of the uterus
Usually left alone if it isn’t causing problems
Usually removed if it’s causing pain or bleeding or if it grows too large can cause infertility
Endometriosis
Growth of endometrium in places other than the uterus
Endometrium goes through the menstrual cycle no matter where it’s located
Lead to infertility and dysmenorrhea (painful periods)
Pregnancy
4 requirements of a pregnancy are
Must be a sperm and egg
Sperm must meet egg
Sperm must fertilize egg
Fertilized egg must implant
Pathway for sperm to meet an egg
Egg must be fertilized within 24 hrs of ovulation if it’s to survive
Fertilization to implantation
Sperm must go thru capacitation to fertilize an egg
Many sperm may be needed to break through the cells surrounding the egg
Only 1 sperm will be allowed to penetrate the egg - rest will be rejected
Nuclei of the sperm and egg rupture the chromosomes mix and a new nucleus forms
Zygote undergoes mitotic division on its way to the uterus
Blastocyst implants in the lining of the uterus 6 days after fertilization
Developing fertilized egg will be called
Blastocyte from implantation-week 3
Embryo from weeks 3-9
Fetus from week 9-birth
Gestation (time of fertilization to birth) is 266 days or 280 days from the start of last menstrual period
Hormonal control
Made by the fertilized egg the corpus luteum and placenta along with other endocrine glands during a pregnancy
Hormone that control a pregnancy include HCG estrogen progesterone HCS thyroid hormone PTH ACTH glucocorticoids and aldosterone
HCG
From the developing blastocyte causes the corpus luteum to continue to secrete estrogen and progesterone
Estrogen levels
Rise 30x normal during a pregnancy
Breasts to double in size encourages external genitalia and uterus to grow causes uterus to be more irritable (prone to contract) and causes pubic symphysis to become more elastic
Progesterone
Suppresses FSH and LH secretion so that no additional eggs are developed during the pregnancy
Suppress uterine contractions promote a rich lining of the uterus for the developing blastocyst and embryo to feed upon and promotes the development of mammary glands and ducts
Produced 1st by the corpus luteum and then by the placenta
HCS
Regulates carb and protein metabolism so that glucose and amino acids are available in the blood for the developing fetus
Reduces mother’s sensitivity to insulin so that more glucose stays in her bloodstream for the fetus it also increases the ability to use fatty acids as a fuel substitute for glucose
Thyroid hormone levels rise
Increases the metabolism for both mother and fetus
Parathyroid hormone
Takes more calcium from blood
Adrenocorticotropic hormone
More glucocorticoids resulting in protein breakdown to produce more glucose for the fetus
Aldosterone
Fluid retention to increase blood volume
Adjustment to pregnancy
Many of the body systems are affected by the pregnancy hormones and the growing fetus’ pressure on the female anatomy
Motility (movement) decreases in the digestive system
Morning sickness
Pressure builds on stomach from the growing fetus
Reflux of stomach acid to the esophagus causes heartburn for the mother
Cardiac output increases 30% due to her increased blood volume
Kidney secrete EPO to boost RBC production
Pressure from the weight of the uterus may cause hemorrhoids or varicose veins
Kidneys produce more urine because blood volume is increased and they’re filtering more waste - from the mother and fetus
More frequent micturition
Respiratory ventilation increases 50%
Breathing is either faster or deeper
Respiratory rate increases because the depth of breaths can’t
Integumentary system is affected in several ways
Stretch marks may appear on abdomen and breasts
Linea alba may darken and be referred to as the linea nigra and melanocytes may increase melanin production producing a mask of pregnancy that’s visible on her face
Increased thyroid hormone secretion
Raises basal metabolic rate by 15%
May feel overheated and have an increased appetite
Nutritional requirements
Only an additional 300 calories are required to sustain a pregnancy
Balanced diet is essential
Folic acid needed to prevent birth defects
Calcium bone development
Protein fecal growth especially during 2nd and 3rd trimesters
Iron increased hemoglobin production to maintain increased blood volume
Imitating the birth process
Fetus has a role in the timing of parturition
Hormones involved in initiating parturition lead to a positive-feedback mechanism that ends with the birth of the baby
3 different stages to the birth process
Dilation of the cervix
Expulsion of the baby
Delivery of the afterbirth
Stage 1
Begins with regular uterine contractions
Cervical canal widens (dilation) and the cervix thins (effacement)
Stage 1 ends when the cervical canal reaches 10 cm (diameter of the fetal head)
Amniotic sac in which the fetus floats often ruptures during this stage
Event is called the breaking of the waters
Stage 2
Baby is expelled
Crowning of the baby’s head is usually seen first
Doctor may make an incision (episotomy) in perineum to widen the vaginal opening
Angled away from the anus to prevent the perineum tearing into anus as the baby is born
Stage 3
Placenta detaches from the uterus and is expelled during this stage
Further contractions of the uterus ensure that all of the placenta and its associated membranes (afterbirth) are expelled
Contractions also help close blood vessels that had led to the placenta
About 350 ml of blood is normally lost when the placenta detaches
Lactation
Milk production is preceded in the first few days after birth by colostrum
Sucking on the breast causes oxytocin release and milk ejection reflex
Prolactin levels surge with each feeding to ensure ample milk production to meet the baby’s needs
Many reasons for nursing include
Breast milk provides good nutrition
Antibodies present provide the baby some immunity
Laxative effects on the baby
Colonize help bacteria in the baby’s intestine
Pregnancy disorders
50% of zygotes don’t survive most are lost before they implant
Of the zygotes that do implant 15% are miscarried due to fetal abnormalities improper implantation premature detachment of the placenta and other causes
Ectopic pregnancy occurs if the fertilized egg implants anywhere other than the uterus
Ectopic pregnancies are doomed
Preeclampsia is a pregnancy induced hypertension accompanied by protein in the urine usually occurs after 20 weeks
Lead to serious potentially fatal consequences for the mother and baby
Placental abruption placenta becomes prematurely detached from the uterine wall
Placenta previa placenta is positioned over the cervix blocking the opening to the uterus
Created by: user-1974945
 

 



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