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Immunology
| Question | Answer |
|---|---|
| What antibody is involved with allergic reactions | IgE |
| What is the most abundant antibody in the body | IgG |
| Antibody | substances that find antigens and kills them |
| Antigen | substances with a foreign marker |
| Lymphocytes | white blood cells formed from lymphatic system |
| B Cells | makes antibodies to attack antigens |
| T Cells | activates lymphocytes to attack antigens |
| Killer T Cells | attack antigen with chemicals |
| Helper T Cells | Activate B cells to produce antibodies |
| Suppressor T Cells | regulate immune system to protect body from its own defense |
| Humoral (Specific) | Specific response cells: t cells, b cells, interferon |
| Innate (nonspecific) | Generalized immunity, nonspecific cells: monocytes, granulocytes, dendritic cells, natural killer |
| What occurs in the body as a bee stings us (or any other foreign antigen) enters our body? | Bee stings and antigen binds with an antibody on a mast cell or basophil Degranulation - causing histamine and heparin to be released Causes: bronchospasm, decreases CO, Vasodilate, Increases vascular permeability, pruritus, urticaria, edema. |
| What cells in the body carry/release histamine | Mast Cells: signal to other cells to react to pathogens Basophils: white blood cell that produces inflammatory cytokines |
| Degranulation | histamine is released |
| Histamine causes.... | -Blood vessles to dialate -Bronchioles to constrict -Systemic vascular resistance drops -Blood pressure drops |
| Urticaria / Pruritus' | Hives / Itching |
| Albuterol | A:2.5mg/3mL SVN P:1.5 - 2.5mg/3mL |
| Dexamethasone | A:10mg P:0.05mg/kg |
| Diphenhydramine (Benadryl) | A:25 - 50mg P:1mg/kg |
| Epi 1:1 IM | A + P: 0.01mg/kg MAX 0.3 - 0.5mg |
| Epi 1:10 IV drip | A: 0.1 - 0.5mcg/kg/min 1mg/1L bag = 1mcg/mL P: 0.1 - 1mcg/kg/min |
| Ipratropium (Atrovent) | A: 500mcg/2.5mL P: 250 - 500mcg / 1.25 - 2.5mL |
| Solu-Medrol | A: 125 - 250 mg IV P: 2mg/kg MAX 60mg |
| Anaphylaxis Drug Treatment | Epi IM every 3 to 5 mins Diphenhydramine Steroids: Solu-Medrol or Dexamethasone Mag 1-2g IV/IO over 10-20 mins |
| Anaphylaxis Treatment | ABC's Epi pen Albuterol / Oxygen IV Vitals |