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פרמקולוגיה א

NSAIDS

TermDefinition
Aspirin שימושים: כאב, חום, דלקת, מניעת אוטם (מינון נמוך). תופעות לוואי: דימום, גירוי קיבה, כיב, Reye’s syndrome בילדים. הערות: מעכב COX באופן בלתי הפיך.
Ibuprofen שימושים: כאב, דלקת, כאבי שרירים, כאבי מחזור. ת"ל: גירוי קיבה, כיב, ירידה בתפקוד כלייתי.
Diclofenac שימושים: כאבים אורטופדיים, דלקות מפרקים. ת"ל: תופעות במערכת העיכול, עלייה בסיכון קרדיווסקולרי.
Naproxen שימושים: כאבי שלד-שריר, כאבי מחזור, דלקת. ת"ל: גסטרואינטסטינלי יחסית בינוני.
Paracetmol לא NSAID! שימושים: כאב וחום בלבד (אין השפעה אנטי-דלקתית). ת"ל: רעילות כבדה במינון יתר. אנטידוט: Acetylcysteine
Celecoxib מעכב COX-2 סלקטיבי → פחות פגיעה בקיבה. שימושים: כאבים, OA, RA. ת"ל: סיכון קרדיווסקולרי גבוה יותר
acetyl cystein אנטידוט להרעלת Paracetamol. שימושים נוספים: מוקוליטיק, COPD. מנגנון: מחזיר מאגרי גלוטתיון ומגן על הכבד.
Created by: Tzipora cantor
 

 



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