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Pema Lama
Nerve Signaling
| Term | Definition |
|---|---|
| Membrane potential | slight excess of positively charged ions on the outside of the membrane and slight deficiency of positively charged ions on the inside of the membrane |
| Polarized membrane | a membrane that exhibits a membrane potential |
| Resting membrane potential (RMP) | Membrane potential maintained by a nonconducting neuron’s plasma membrane; typically 70 mV. The slight excess of positive ions on a membrane’s outer surface is produced by ion transport mechanisms and the membrane’s permeability characteristics |
| Sodium-potassium pump | Active transport mechanism in plasma membrane that transports Na and K in opposite directions and at different rates Maintains an imbalance in the distribution of positive ions, in the inside surface becoming slightly negative with respect to its oute |
| Local potentials | slight shift away from the resting membrane in a specific region of the plasma membrane |
| Excitation | when a stimulus triggers the opening of additional Na channels, allowing the membrane potential to move toward zero (depolarization) |
| Inhibition | when a stimulus triggers the opening of additional K channels, increasing the membrane potential (hyperpolarization) |
| graded potentials | Local potentials are called graded potentials because the magnitude of deviation from the resting membrane potential is proportional to the magnitude of the stimulus |
| Action potential | —the membrane potential of a neuron that is conducting an impulse; also known as a nerve impulse |
| Absolute refractory period | brief period (lasting approximately 0.5 ms) during which a local area of a neuron’s membrane resists restimulation and will not respond to a stimulus, no matter how strong |
| Relative refractory period | time during which the membrane is repolarized and restoring the resting membrane potential; the few milliseconds after the absolute refractory period; will respond only to a very strong stimulus |
| Types of synapses (junctions): Electrical synapses | occur where cells joined by gap junctions allow an action potential to simply continue along postsynaptic membrane |
| Types of synapses (junctions): Chemical synapses | occur where presynaptic cells release chemical transmitters (neurotransmitters) across a tiny gap to the postsynaptic cell, possibly inducing an action potential there |
| Synaptic knob | tiny bulge at the end of a terminal branch of a presynaptic neuron’s axon that contains vesicles housing neurotransmitters |
| Synaptic cleft | space between a synaptic knob and the plasma membrane of a postsynaptic neuron |
| Arrangements of synapses: Axodendritic | axon signals postsynaptic dendrite; common |
| Arrangements of synapses: Axosomatic | axon signals postsynaptic soma; common |
| Arrangements of synapses: Axoaxonic | axon signals postsynaptic axon; may regulate action potential of postsynaptic axon |
| Plasma membrane of a postsynaptic neuron | has protein molecules that serve as receptors for the neurotransmitters |
| Spatial summation | adding together the effects of several knobs being activated simultaneously and stimulating different locations on the postsynaptic membrane, producing an action potential |
| Temporal summation | when synaptic knobs stimulate a postsynaptic neuron in rapid succession, their effects can summate over a brief period to produce an action potential |
| Short-term memories (seconds or minutes) | may result from axoaxonic facilitation or inhibition of the presynaptic axon terminal |
| Intermediate long-term memory (minutes to weeks) | happens when serotonin blocks potassium channels in the presynaptic terminal—thus prolonging the action potential and increasing the amount of neurotransmitter released |
| Long-term memories (months or years) | require structural changes at the synapse—for example, more vesicles, more vesicle release sites, more presynaptic terminals, more sensitive postsynaptic membranes |
| Neurotransmitters | means by which neurons communicate with one another; there are more than 50 compounds known to be neurotransmitters, and dozens of others are suspected |
| Function of a neurotransmitter | is determined by the postsynaptic receptor |
| Two major functional classifications of Neurotransmitters | excitatory neurotransmitters and inhibitory neurotransmitters |