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Antilipemic Drugs

Antilipemic drugs

QuestionAnswer
HMG-COA reductase inhibitors Reduce production of Cholesterol synthesis - most potent LDL reducer - Decrease LDL and TG - Increase HDL
What are the side effects of HMG-COA reductase inhibitors Muscle pain Increased liver enzymes Constipation Headache
Bile acid sequestrants Trap bile in the gut so it causes the body to use cholesterol to make more - Decreases LDL - Start with "Chol or col"
Side effects of Bile acid sequestrants Constipation GI upset Interferes with absorption of other meds
Niacin (B3) Reduces triglyceride production - Decrease LDL and TG - Increase HDL
SA of Niacin (B3) Flushing, itching, GI problems
Fibrates Increases breakdown of triglycerides = increase HDL cholesterol Have "fib" in the name
SA of Fibrates Gallstones GI Upset
Ezetimibe Blocks cholesterol absorption in gut Decreases LDL Added to statins
Teaching for HMG-COA reductase inhibitors - Because endogenous cholesterol rises @ night - take at night/evening - Monitor liver enzymes - Avoid grapefruit juice - Not safe for pregnancy
What would be the signs of bile acid sequestrant overdose? Overdose = obstruction - Constipation - Abd. pain - Bloating - Nausea
Teaching for bile acid sequestrants All meds need to be taken 1 hour before or 4-6 hours after administration.
What are the health teaching for Niacin Take asprin or NSAID 30 min before can help with flushing
SA of Ezetimibe Rare - M. pain - Rhabdomyolysis - Hepatitis - Pancreatitis - Low platelets
Created by: ahgecas25
 

 



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