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pharmacology 22
| Question | Answer |
|---|---|
| Drugs ending in -salazine | used with ulcerative colitis and crohn's disease to treat INFLAMATION |
| Which drug does not induce remission of Crohn disease | olsalazine - an antiinflammatory - Aminosalicylates |
| azathioprine, 6-Mercaptopurine, Methotrexate | an immunosuppressive medications used to treat autoimmune diseases |
| infliximab | immunomodulator reduces inflammation in auto immune diseases - crohns / ulcerative colitis |
| drugs that induce remission of crohns disease | aminosalicilaytes, corticosteroids, immunomodulators, biologics |
| drugs ending in -umab | immunomodulator used to treat crohns and ulcerative colitis |
| drugs ending in -prine, -purine | immosuppressive drugs |
| condition Sometimes called colitis | ibs |
| 95% of the body's serotonin is found in the | stomach epithelium |
| cause GI motility problems | low levels of serotonin |
| •Gastroenteritis may trigger | postinfectious ibs |
| It produces inflammation in the upper layers of the lining of the small intestine and colon. | ulcerative colitis |
| Produces inflammation deep in the intestinal wall/ Anywhere along the entire GI tract | crohns disease |
| Rectal bleeding, Anemia , weight loss, loss of vitamins/minerals, joint pain,fever | symptoms in crohns and ulcerative colitis but not IBS |
| Alosetron (NOT AVAILABLE IN CANADA) | Serotonin receptor antagonist used to treat IBS - Antagonizes 5-HT3 receptors in the vagal nerves of the intestines , reducing gastric motility, regulating transit through the colon, controlling GI secretion, and easing visceral pain. |
| Lubiprostone (not available in canada) | Prostaglandin E1 derivative Used to treat IBS Activates type 2 chloride channels in the gut, increasing the flow of chloride ions into the intestines, which boosts secretions. |
| Diphenoxylate + atropine (Lomotil®) • Loperamide (Imodium®) | Opioid antidiarrheal Bind to opioid receptors on smooth muscle cells of the GI tract. |
| Polycarbophil | bulk forming laxative to treat IBS not available in Canada |
| Atropine, Dicyclomine | Anticholinergics used to treat IBS Produces a nonspecific, direct spasmolytic action on smooth GI muscle. Decrease gastrointestinal muscular tone and motility, which helps relieve cramping and abdominal pain. |
| Aminosalicylates | Anti‑inflammatory treatment in IBD (ulcerative colitis, Crohn’s disease |
| DRUGS ending in -alazine - alamine | Aminosalicylates- most are prodrugs - decreases bacteria in colon |
| •Mesalamine(5-ASA) | Aminosalicylate- suppository, rectal suspension, delayed release pills -Releasing the active drug in a less acidic environment, such as the small intestine. |
| Immunosuppressants | Azathioprine, Methotrexate Suppresses T-cell–mediated immune system response |
| immunomodulator moa | Blocks the inflammatory process triggered by high concentrations of TNF and reduces T-cell–mediated intestinal inflammation. |
| warning label immunomodulator | It may cause discoloration of urine or feces, should be avoided during pregnancy and while breastfeeding, and could increase the risk of infection. |
| Fistula | formed during Crohn's An abnormal tunnel or passage that develops between two parts of the intestine/ can trap stool, bacteria, and secretions causing infection |
| anti‑infective medications | are often required alongside Crohn’s standard therapies to manage complications the deep inflammation of the intestinal wall can cause fistulas (abnormal passages) to form. These fistulas are prone to infection |
| Antiinfectives: • Treatment of fistulas | Ampicillin • Sulfonamides • Cephalosporins • Tetracycline • Metronidazole |
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