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Epilepsy .PCOL.Final

QuestionAnswer
What are the classifications of seizures? Focal: Focal aware (simple partial) Focal w/ impaired awareness (complex partial) Focal to bilateral tonic-clonic Generalized: Absence seizure (petit mal) myoclonic seizures Tonic clonic seizures (Grand mal)
What is typically the cause of focal seizures? cortical lesion
What is typically the cause of generalized seizures? genetic factors
List some seizure disorders that are a result of genetic factors: Infantile spasms Dravet Syndrome Lennox-Gastaut syndrome
What are the four major classes of antiseizure drugs? 1. modulators of voltage-gated cation channels (Na, Ca, K) 2. modulators of GABA neurotransmission 3. Modulators of neurotransmitter release 4. Decrease glutamatergic neurotransmission
List the drugs that enhance Na+ channel inactivation? (7) lamotrigine phenytoin topiramate lacosamide zonisamide carbamazepine valproate
What are the SE of phenytoin? decrease contraceptive efficacy (CYP3A4 inducer) metabolized via CYP2C9 = saturated easily = toxicity SE: arrhythmias , coma, ataxia
What is phenytoin indicated for:? focal and tonic-clonic seizures
Created by: user-2008321
 

 



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